Analgesic and antiinflammatory effects of mollic acid glucoside, a 1<i>α</i>‐hydroxycycloartenoid saponin extractive from <i>Combretum molle</i> R. Br. ex G. Don (Combretaceae) leaf

Ojewole, John A. O.

doi:10.1002/ptr.2253

Cited by 23 publications

(14 citation statements)

References 22 publications

(38 reference statements)

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“…This is conforming to the results of Novatus et al (2012), which revealed the presence of these secondary metabolites in the hydro-ethanol extract of Combretum adenogonium. These metabolites were known for these biological activities such as: antiviral, antibacterial, anti-inflammatory and analgesic activity (Tsuchiya et al 1996 andOjewole, 2008). Yahaya et al (2012) also revealed the presence of flavonoids, , tannins, glycosides, derivatives quinoniques and alkaloids in crude extract of a plant of the same family (Combretum glutinosum).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Biological Activities of Combretum adenogonium Leaves Extracts

Nounagon

Dah-Nouvlessounon

N’tcha

et al. 2017

ESJ

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Combretum adenogonium is beniniens pharmacopoeia medicinal plant used for the treatment of various diseases. This work aims to study the phytochemical and assess some biological activities of C. adenogonium leaves extracts. The phytochemical analysis (qualitative et quantitative) was conducted by standard analytical chemistry method. Antioxydant activity was evaluated by the DPPH method. Antibacterial activity was evaluated in vitro with 10 references strains , 10 Staphylococcus strains isolated from European Scientific Journal October 2017 edition Vol.13, No.30 ISSN: 1857 -7881 (Print) e -ISSN 1857 359 meat products and 10 clinical Staphylococcus aureus strains isolated from Buruli ulcer lesions and pus. The Minimum Inhibitory Concentration (MIC) and Bactericidal (CMB) were determined by macrodilution method. The extracts cytotoxic effect was evaluated with Artemia salina larvae. The phytochemical screening revealed the presence of flavonoids, tannins, anthocyanins, saponin and triterpenoids. The methanolique extract present the higest content (450.66 ± 0.004 µg EAG/mg) of total polyphenolic compound. The results showed the good antioxidant activity. The inhibitory diameter zone vary (p < 0.001) according to the strains. The largest medium inhibitory diameter (21.85 ± 0.17 mm) was obtained with the ethanolic extract, while the lowest (6.00 ±0.00 mm) were recorded with water-ethanol extract. The variation between CMI and CMB is not significant (p > 0.05). The higher LD50 (27.66 mg/ml) was recorded with methanol extract. The results of this study confirm some use of C. Adenogonium extracts. But; these extracts must be use with moderation.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Biological Activities of Combretum adenogonium Leaves Extracts

Nounagon

Dah-Nouvlessounon

N’tcha

et al. 2017

ESJ

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“…As a result, level of CRP, as indicator of systemic inflammation, in plasma highly increases during acute phase response to tissue injury, infection, or other inflammatory stimuli (Gruys et al, 2005). Different in vitro studies suggested that mollic acid glucoside isolated from C. molle leaves has antiinflammatory and anti-asthmatic activities (Ojewole et al, 2008;Shah et al, 2011;Yeo et al, 2012). However, in the current in vivo study, the observed elevated level of CRP, an indicator of systemic inflammation, could be due to the damaged liver, since elevated liver enzymes are associated with higher CRP concentrations and liver is the main produced of CRP (Kerner et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Effect of Combretum molle (Combretaceae) seed extract on hematological and biochemical parameters

Anato¹,

Bezabih²,

Ketema³

2018

J. Med. Plants Res.

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Combretum molle (Combretaceae) is widely used traditional medicinal plant for treatment of different illnesses in most parts of Africa. However, its in vivo toxic effect is not evaluated yet. Thus, the aim of this study was to evaluate cytotoxic effect of C. molle seed extract on biochemical and hematological parameters using mice. Accordingly, effect of seed extract of the plant on hematological and biochemical parameters and on tissues of different organs were determined. Blood sample collected on the next day of the last dose administration was used for further analysis. Organs were collected in formalin for histological study. Result of the study showed that seed extract of C. molle did not cause significant effects on most red blood cells (RBCs) indices. Also, except eosinophil count, all white blood cells (WBCs) indices showed significant reduction (P<0.05) under use of almost all doses of the seed extract. Level of liver enzymes such as glutamic oxaloacetate transaminase (sGOT) and glutamic pyruvic transaminase (sGPT) showed significant increment (P<0.05) in mice treated with different doses of the plant seed extract, while concentration of albumin was significantly reduced (P<0.05). Similarly, significant increament (P<0.05) in levels of kidney function indicators urea and creatinine was observed. At relatively lower dose (125 mg/kg), the crude extract of C. molle seed showed lower effects on haematological, biochemical and immunological parameters. As dose increased, its cytotoxic effect increased.

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“…Seu extrato contém flavonoides e catequinas que são inibidores da prostaglandinas e processos inflamatórios 16 . As pesquisas [17][18][19][20] demonstram e comprovam a atividade anti-inflamatória da X. americana confirmando de forma mais consistente os dados encontrados na ação da planta em sete dias pós-tratamento.…”

Section: Contribuições Dos Autoresunclassified

Eficácia Da Fonoforese Com Ximenia Americana L. Na Inflamação De Tendão De Ratos

Leal

Uchôa

Figuerêdo-Silva

et al. 2016

Rev Bras Med Esporte

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Introdução: Diversos recursos terapêuticos, como laser e ultrassom isolado, combinados com fármacos e fonoforese têm sido utilizados em casos de inflamação e reparo de tendão, sendo o ultrassom pulsado bastante eficaz em tendinites crônicas. Objetivo: Analisar a eficácia do uso da fonoforese com o extrato etanólico das cascas do caule da Ximenia americana L. na resolução do processo inflamatório crônico em Rattus norvegicus. Métodos: A amostra consistiu em 120 animais para análise da resposta inflamatória, utilizando-se como variáveis edema, força biomecânica, número de fibroblastos e análise histológica. Resultados: Nos 7° e no 14° dia, verificou-se diferença significativa entre o grupo ultrassom com gel do caule de Ximenia americana L. e o grupo ultrassom com placebo (p < 0,05) quanto à redução de edema, aumento da força máxima de ruptura, redução extremamente significativa da deformação máxima (p < 0,001), além de aumento dos fibroblastos. Na análise histológica, houve melhora do processo inflamatório inicial e aceleração do reparo tendíneo, com redução de células inflamatórias e com deposição de colágeno organizado com matriz extracelular densa. Conclusão: O ultrassom pulsado combinado com o gel do caule de Ximenia americana L. é uma forma terapêutica eficaz para a resolução do processo inflamatório crônico.Descritores: fonoforese; olacaceae; inflamação; tendão do calcâneo. ABSTRACT Introduction: Several therapeutic resources such as laser and isolated ultrasound combined with drugs and phonophoresis have been used in cases of inflammation and tendon repair, and the pulsed ultrasound is quite effective in chronic tendinitis. Objective: To analyze the efficacy of phonophoresis with the ethanol extract of the stem bark of Ximenia americana L. to manage the chronic inflammatory process in Rattus norvegicus

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Analgesic and antiinflammatory effects of mollic acid glucoside, a 1α‐hydroxycycloartenoid saponin extractive from Combretum molle R. Br. ex G. Don (Combretaceae) leaf

Cited by 23 publications

References 22 publications

Phytochemical Screening and Biological Activities of Combretum adenogonium Leaves Extracts

Phytochemical Screening and Biological Activities of Combretum adenogonium Leaves Extracts

Effect of Combretum molle (Combretaceae) seed extract on hematological and biochemical parameters

Eficácia Da Fonoforese Com Ximenia Americana L. Na Inflamação De Tendão De Ratos

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