Objective: The present study was undertaken to evaluate antifungal potential of improved crude extracts of Mitracarpus scaber Zucc., an ivorian traditional medicinal plant against two species of clinical yeast isolates: Candida parapsilosis and Candida guilliermondii. Methods:For evaluation of antifungal activity, double dilution method in slope tubes was used. Crude extracts of M. scaber were prepared by extracting with a blender in aqueous and hydroalcohol. In first; Aqueous (X Aq ) and Hydroalcoholic (X 0 ) extracts were evaluated, and secondary the crude extract X 0 was improved by partition in mixture of aqueous and hexanic solvent 50:50 v/v. Each dried phase was also examined. A phytochemical screening has been performed on most active extracts. Results:In vitro antifungal activity showed that crude extract X 0 was the most active with MIC = 6.25 mg/ml. Among the extracts obtained by partition from extract X 0 , extract X 11 (Hexanic phase) was the better with lowest antifungal parameters MIC and MFC range between 1.562 mg/ml and 0.781 mg/ml and IC 50 range between 0.73 mg/ml to 0.598 mg/ml. In addition, the most active extract contained only terpens and steroids.Conclusions: Antifungal activity of M. scaber was improved by partition of an hydroalcoholic extract (X 0 ) in mixture hexane-water 50:50 v/v. Hexanic phase (X 11 ) was more active against C. parapsilosis and C. guilliermondii.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.