Antifúngicos sistémicos. Farmacodinamia y farmacocinética

Catalán, M.; Montejo, Juan Carlos

doi:10.1016/s1130-1406(06)70012-2

Cited by 38 publications

(25 citation statements)

References 60 publications

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“…The acute reactions are related to the perfusion of the drug and the release of TNF-α and IL-6, with the main reactions being fever, chills, arthralgia, nausea, vomiting, headaches and hypotension (5,20,22). The acute reactions most prevalent in this study corroborate those of Roxanna et al, who found fever (25%), vomiting (15.2%) and phlebitis (6.7%) 4 .…”

Section: Discussionsupporting

confidence: 88%

Adverse Reactions to Amphotericin B in Adults - Data Mining

Loução¹,

Jacomini²,

Moroni³

et al. 2018

Rev. Bras. Farm. Hosp. Serv. Saúde

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Background: Amphotericin B deoxycholate (d-AmB) is a drug widely used in fungal infections. The adverse effects of this medicine may be acute (infusion-related) or late (cumulative dose-related). Objective: This study aims to evaluate the frequency of adverse reactions to amphotericin B deoxycholate (d-AmB) in adults in a University Hospital, describe the profile of drug use in the institution and evaluate the factors related to the development of reactions with the aid of data mining. Methods: A database with the characteristics of the patients and information about the adverse reactions was created. Then, data mining was performed with the aid of WEKA software. Results: Fifteen adult patients who had used d-AmB in the selected period were identified, being 60% male. The mean age was 41.8 years old. Only 6 patients concluded their treatments with d-AmB, the others had to interrupt the treatment due to some intercurrence. Among the acute phase reactions, the most frequent were vomiting, nausea, phlebitis, hyperthermia and headache, which were related to the drug infusion. As for subacute reactions, the most frequent were urea and creatinine elevation, and hypokalemia. 30 rules were identified after data mining: d-AmB longer-term use, even with normal initial creatinine and urea, they had a greater number of acute reactions; patients with no creatinine change during d-AmB treatment had less subacute reactions; higher number of nephrotoxic drugs use, in those with increased creatinine, they presented a greater number of subacute reactions. Conclusions: The results demonstrate that there is a relation between the time of use and the greater number of adverse reactions. This safety data help clinicians to make decisions.

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Section: Discussionsupporting

confidence: 88%

Adverse Reactions to Amphotericin B in Adults - Data Mining

Loução¹,

Jacomini²,

Moroni³

et al. 2018

Rev. Bras. Farm. Hosp. Serv. Saúde

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“…A ação primária dos antibióticos poliênicos consiste na alteração da permeabilidade celular da membrana fúngica, tendo maior afinidade pelo ergosterol dos fungos do que pelo colesterol dos mamíferos (CATALÁN; MONTEJO, 2006;ROCHA; Em medicina humana a anfotericina B é recomendada como de primeira escolha no tratamento da esporotricose em gestantes e nas formas mais graves da doença em crianças.…”

Section: Poliênicos (Anfotericina B)unclassified

Terapêutica Da Esporotricose: Revisão

Rosa

Meinerz²,

Osório³

et al. 2018

SCI. ANIM. HEALTH

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RESUMOesporotricose é considerada uma micose emergente de importância para a saúde pública, especialmente devido aos frequentes relatos zoonóticos envolvendo o felino doméstico. São crescentes as casuísticas animal e humana da micose, assim como os relatos de casos refratários à terapia convencional, principalmente nos casos de esporotricose felina. Nesse sentido, o trabalho descreve e discute as opções terapêuticas mais utilizadas, além de citar alternativas disponíveis para o tratamento da micose. Os resultados indicam ser o itraconazol o fármaco de primeira escolha, especialmente nos felinos domésticos, tendo o iodeto de potássio, terbinafina e cetoconazol como alternativas de tratamento. O estudo ressalta o uso da anfotericina B nos casos resistentes, assim como descreve as intervenções cirúrgicas e a termoterapia nos casos de falha terapêutica e quando as lesões eram localizadas. Com esses resultados o estudo conclui que dentre as terapias utilizadas para a esporotricose nos animais, o itraconazol mesmo com os crescentes relatos de falhas terapêuticas, permanece sendo o fármaco de primeira escolha, especialmente nos casos da micose em felinos. As demais opções são utilizadas nos casos mais graves da micose ou em situações em que o itraconazol não se mostra efetivo frente ao agente. Palavras

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“…12 Therefore, patients with APL on ATRA therapy may need antifungal therapy. [13][14][15] Since its discovery, in 1955, amphotericin B (AB) 16,17 remains as the antimicrobial of choice for this practice, as well as for the treatment of confirmed systemic fungal infections. 16,18 However, AB is associated with chronic and acute adverse effects, especially nephrotoxicity, which may cause renal damage and electrolytic disorder (hypokalemia and hypomagnesemia).…”

Section: 4mentioning

confidence: 99%