Antifungal and antibacterial activities of Taxus wallichiana Zucc

Abstract

Current study was undertaken to evaluate the in vitro antifungal and antibacterial potential of methanol extract and subsequent fractions obtained after partitioning in organic solvents with variable polarity of the aerial parts of the tree Taxus wallichiana Zucc. Traditionally, this plant is often used in folk medicines in Pakistan for treating microbial infections. In order to rationalize the traditional use, methanol extracts of leaf, bark, and heartwood of Taxus wallichiana Zucc. were tested against six bacteria and six fungal strains using the Hole diffusion and macro-dilution methods. All extracts and fractions displayed significant antimicrobial effect. Only three fungal strains, Trichophyton longifusus, Microspoum canis, and Fusarium solani were susceptible to the extracts and fractions with MICs ranging from 0.08 to 200 mg/mL. In case of bacterial strains, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi were susceptible to the extracts and fractions with MICs ranging from 0.08 to 200 mg/mL. Comparison results were carried out using imipinem, miconazole and amphotericin B as standard antibiotics.

Antimicrobial activities of Conyzolide and Conyzoflavone from Conyza canadensis

“…General extraction procedures were adopted as reported earlier [7][8][9][10][11][12] . The whole plant material dried under shade was chopped and pulverized into fine powder.…”

Evaluation of antimicrobial, antioxidant and cytotoxic properties of bioactive compounds produced from endophytic fungi of Himalayan yew (Taxus wallichiana) in Nepal

“…(Himalayan yew) is an evergreen coniferous tree (10 to 28 meters in height), native to the Himalaya and parts of southeast Asia that grows on steep, moist mountain slopes at altitudes of about 2000 m to 3500 m above sea level. It has flat and dark green leaves, which are arranged spirally on the stem 1 . The leaves and bark of Taxus species are the primary source of the chemotherapeutic drug Paclitaxel used in the treatment of breast and ovarian cancer, resulting in it receiving huge attention worldwide 2 .…”

“…The Himalayan yew also has an exceptional history of its application in the traditional system of medicine for the treatment of fever and painful inflammatory conditions. It is also consumed as decoctions, herbal tea, and juice for treating cold, cough, respiratory infections, indigestion, and epilepsy and also on infected wounds and burns as poultice 1,3 . Some research indicates various medicinal properties of T. wallichiana, such as analgesic, antipyretic, anti-inflammatory, immunomodulatory, antibacterial, antifungal, antiplatelet, antispasmodic, antiallergic, anticonvulsant, antiosteoporotic, and vasorelaxing effect [3][4][5][6] .…”

Quality Standards and Antioxidant Activity of Siddha Formulation Cuvacakutori Chooranam

“…24 It shows analgesic, antipyretic, anticonvulsant, anti-inflammatory, antimicrobial, antifungal and immunomodulatory effects. [25][26][27][28] Terpene, alcohol, aldehyde, organic acid, acid esters, alkanes and alkenes are the main phytochemicals of T. wallichiana leaves. 29 Taxol is the main active compound is widely used in cancer treatment.…”