Antifungal activity of steroidal glycosides from <i>Yucca gloriosa</i> L.

Favel, Anne; Кемертелидзе, Э. П.; Benidze, M. M.; Fallague, Karim; Régli, P.

doi:10.1002/ptr.1644

Cited by 29 publications

(26 citation statements)

References 8 publications

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“…The antifungal activity of a crude extract from Yucca gloriosa L. (Agavaceae) flowers, named alexin, was investigated in vitro against a panel of human pathogenic fungi and yeasts, as well as dermatophytes and filamentous species. 47 Alexin had a broad spectrum of antifungal activity for all the tested yeast strains, except for Candida lusitaniae and Candida kefyr. It was also active against several clinical Candida isolates known to be resistant to the usual antifungal agents.…”

Section: Crude Extractsmentioning

confidence: 91%

Active antifungal substances from natural sources

Abad¹,

Ansuategui²,

Bermejo³

2006

Arkivoc

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The spread of multidrug-resistant strains of fungus and the reduced number of drugs available, makes it necessary to discover new classes of antifungals and compounds that inhibit these resistant mechanisms. This has led to a search for therapeutic alternatives, particularly among medicinal plants and compounds isolated from them used for their empirically antifungal properties. In these natural sources, a series of molecules with antifungal activity against different strains of fungus have been found, which are of great importance to humans and plants. In this article, we review the main sources of molecules with antimycotic activity obtained from the natural environment.

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Section: Crude Extractsmentioning

confidence: 91%

Active antifungal substances from natural sources

Abad¹,

Ansuategui²,

Bermejo³

2006

Arkivoc

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“…De acordo com Favel et al (2005), o extrato bruto de glicosídeos esteroidais de flores de Yucca gloriosa, apresenta atividade antifúngica e, foi investigado in vitro contra a ação de fungos fitopatógenos. Os resultados encontrados apontam que os principais glicosídeos esteroidais como tigogenilo, yuccaloeside B e yuccaloeside C obtiveram um controle do crescimento do fungo, sendo a concentração inibitória mínima entre 0,39 e 6,25 μg/mL para todas as leveduras testadas.…”

Section: Fundamentação Teóricaunclassified

Produção E Aplicação De Extrato Hidroalcoólico De Gracilaria Birdiae No Controle Do Fungo Fusarium Pallidoroseum

Batista¹,

Vasconcelos²,

Júnior³

et al. 2017

Produção E Aplicação De Extrato Hidroalcoólico De Gracilaria Birdiae No Controle Do Fungo Fusarium Pallidoroseum

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ResumoO Brasil é classificado como o terceiro maior produtor de frutas no mundo, sendo o melão o grande destaque pelo seu potencial de produção e exportação, principalmente na região Nordeste. Devido à necessidade de alternativas para controle de doenças do melão, com menos prejuízos ao meio ambiente, têm-se feito pesquisas com algas marinhas e seus compostos bioativos, capazes de substituir o uso indiscriminado de pesticidas. Nesse cenário, o presente estudo teve como objetivo avaliar a atividade antifúngica do extrato hidroalcoólico bruto de Gracilaria birdiae no fungo transmissor da doença de podridão, Fusarium pallidoroseum, recorrente na cultura do melão (Cucumis melo). A alga vermelha Gracilaria birdiae foi coletada na praia de Pitangui, localizada em Extremoz (RN), e foi feita a secagem e produção do extrato hidroalcoólico. Na triagem fitoquímica da alga realizou-se testes para os compostos bioativos alcalóides, taninos, esteroides, saponinas, antocianinas, antocianidinas e flavonoides. Por conseguinte, o teste antifúngico do extrato da Gracilaria birdiae em fungo Fusarium pallidoroseum foi determinado pelo teste de inibição de halo nas concentrações de 100 μL L-1 e 1000 μL L-1. Os resultados obtidos na triagem fitoquímica do extrato hidroalcoólico demonstraram a presença de compostos bioativos alcaloides e esteroides. A presença ou ausência de fitoquímicos demonstram que dependendo do solvente utilizado, o perfil dos compostos bioativos extraídos difere. Diante dos resultados do presente estudo, evidenciou-se que o extrato hidroalcoólico bruto de Gracilaria birdiae não promoveu atividade antifúngica frente ao fungo Fusarium pallidoroseum, o que pode estar relacionado à alta quantidade de carboidratos (manose) presente no extrato. Dessa forma, apesar do solvente hidroalcoólico ter um baixo custo e toxicidade, o extrato hidroalcoólico favoreceu o crescimento do microrganismo testado, ocasionando resultados insatisfatórios para o controle do fungo Fusarium pallidoroseum. Sendo assim, sugere-se que, por meio desta pesquisa, futuros trabalhos possam testar a aplicabilidade do extrato de Gracilaria birdiae usando uma variedade maior de solventes para obter um perfil diferente de compostos e realizar novos testes antifúngicos.Palavras-Chave: Gracilaria birdiae, Fusarium pallidoroseum, Compostos bioativos, Extrato hidroalcoólico.

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“…The methanol extract was concentrated and re-extracted with methanol and acetone (1:5, v/v; Yan et al 1996).The precipitate obtained was dried under vacuum, which turns to a whitish amorphous powder after complete drying. It was loaded on Merck silica gel-60 (230-400 mesh) column and eluted with chloroform-methanol-water (70:30:10; Favel et al 2005). The first fraction collected was air-dried at room temperature (28°C), and the residue obtained was treated as pure saponins of G. sylvestre.…”

Section: Larvicidal Bioassaymentioning

confidence: 99%

Biolarvicidal compound gymnemagenol isolated from leaf extract of miracle fruit plant, Gymnema sylvestre (Retz) Schult against malaria and filariasis vectors

Khanna

Каннабиран

Rajakumar³

et al. 2011

Parasitol Res

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Owing to the fact that the application of synthetic larvicide has envenomed the surroundings as well as non-target organisms, natural products of plant origin with insecticidal properties have been tried as an indigenous method for the control of a variety of insect pests and vectors in the recent past. Insecticides of plant origin have been extensively used on agricultural pests and, to a very limited extent, against insect vectors of public health importance, which deserve careful and thorough screening. The use of plant extracts for insect control has several appealing features as these are generally more biodegradable, less hazardous and a rich storehouse of chemicals of diverse biological activities. Moreover, herbal sources give a lead for discovering new insecticides. Therefore, biologically active plant materials have attracted considerable interest in mosquito control study in recent times. The crude leaf extracts of Gymnema sylvestre (Retz) Schult (Asclepiadaceae) and purified gymnemagenol compound were studied against the early fourth-instar larvae of Anopheles subpictus Grassi and Culex quinquefasciatus Say (Diptera: Culicidae). In the present study, bioassay-guided fractionation of petroleum ether leaf extract of G. sylvestre led to the separation and identification of gymnemagenol as a potential new antiparasitic compound. Phytochemical analysis of G. sylvestre leaves revealed the presence of active constituents such as carbohydrates, saponins, phytosterols, phenols, flavonoids and tannins. However, cardiac glycosides and phlobatannins are absent in the plant extracts. Quantitative analysis results suggested that saponin (5%) was present in a high concentration followed by tannins (1.0%). The 50 g powder was loaded on silica gel column and eluted with chloroform-methanol-water as eluents. From that, 16 mg pure saponin compound was isolated and analysed by thin layer chromatography using chloroform and methanol as the solvent systems. The structure of the purified triterpenoid fraction was established from infrared (IR), ultraviolet (UV), (1)H nuclear magnetic resonance (NMR), (13)C NMR and mass spectral data. The carbon skeleton of the compound was obtained by (13)C NMR spectroscopy. The chemical shift assignments obtained for gymnemagenol from (1)H NMR correspond to the molecular formula C(30)H(50)O(4). The compound was identified as 3β, 16β, 28, 29-tetrahydroxyolean-12-ene (gymnemagenol sapogenin). Parasite larvae were exposed to varying concentrations of purified compound gymnemagenol for 24 h. The results suggested that the larval mortality effects of the compound were 28%, 69%, 100% and 31%, 63%, 100% at 6, 12 and 24 h against A. subpictus and C. quinquefasciatus, respectively. In the present study, the per cent mortality were 100, 86, 67, 36, 21 and 100, 78, 59, 38 and 19 observed in the concentrations of 1,000, 500, 250, 125 and 62.75 ppm against the fourth-instar larvae of A. subpitcus and C. quinquefasciatus, respectively. The purified compound gymnemagenol was tested in concentrations of 8...

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Antifungal activity of steroidal glycosides from Yucca gloriosa L.

Cited by 29 publications

References 8 publications

Active antifungal substances from natural sources

Active antifungal substances from natural sources

Produção E Aplicação De Extrato Hidroalcoólico De Gracilaria Birdiae No Controle Do Fungo Fusarium Pallidoroseum

Biolarvicidal compound gymnemagenol isolated from leaf extract of miracle fruit plant, Gymnema sylvestre (Retz) Schult against malaria and filariasis vectors

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