Antidiabetic properties of the alcoholic extract of Sphaeranthus indicus in streptozotocin-nicotinamide diabetic rats

Abstract

We have investigated the possible antihyperglycaemic effects of Sphaeranthus indicus extract in rats rendered diabetic by nicotinamide (120 mgkg −1 i.p.) and streptozotocin (STZ) (60 mgkg −1 i.p). Fasting plasma glucose levels, serum insulin levels, serum lipid profiles, magnesium levels, glycosylated haemoglobin, changes in body weight and liver glycogen levels were evaluated in normal and diabetic rats. Oral administration of S. indicus for 15 days resulted in significant decrease in blood glucose levels and increases in hepatic glycogen and plasma insulin levels. Fasting normal rats treated with the alcoholic extract of S. indicus showed significant improvement in oral glucose tolerance test.Glibenclamide was used as a reference standard. The findings demonstrate that the alcoholic S. indicus extract may be useful in the treatment of diabetes.

Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

“…This could be due to dehydration, increase in muscle wasting (56) and catabolism of fats and proteins (57). These results run parallel with the studies of Pierre et al, (47) and Sharma et al, (58).…”

Investigation of hypoglycemic, hypolipidemic and antioxidant activities of aqueous extract of Terminalia paniculata bark in diabetic rats

“…Kidney is playing a key role to remove the metabolic waste such as creatinine and urea from body, thereby helping to maintain body homeostasis of above substances. The persistent hyperglycemia, haemodynamic changes within the kidney tissue and free radical generation mediated stress in diabetes produce renal dysfunction which results in elevation of urea and creatinine levels in blood [21][22][23] . In the present study, elevated levels of SGOT, SGPT, urea and creatinine suggested the occurrence of liver and kidney damages after the administration of STZ to the rats compared to normal control rats.…”

Sphaeranthus indicus Linn.: A phytopharmacological review

“…Oral administration of S. indicus for 15 days resulted in a significant decrease in blood glucose levels and increase in hepatic glycogen and plasma insulin levels. [45]…”