Investigation of hypoglycemic, hypolipidemic and antioxidant activities of aqueous extract of Terminalia paniculata bark in diabetic rats

Ramachandran, Subramaniam; Rajasekaran, A.; Manisenthilkumar, KT

doi:10.1016/s2221-1691(12)60020-3

Cited by 76 publications

(53 citation statements)

References 31 publications

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“…Antidiabetic activities have also been reported for several Asian Terminalia species including T. arjuna (Ragavan and Kumari 2006), T. bellerica (Kannan et al 2012;Kasabri et al 2010), T. catappa (Ahmed et al 2005;Nagappa et al 2003), T. chebula (Kumar et al 2006;Rao et al 2006), T. pallida and T. paniculata (Ramachandran et al 2012). T. chebula ethanolic extracts were found to decrease the levels of blood glucose and glycosylated haemoglobin in a streptozocin-induced diabetic rat model (Kumar et al 2006).…”

Section: Antidiabetic Activitymentioning

confidence: 84%

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

2015

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Plants of the genus Terminalia are amongst the most widely used plants for traditional medicinal purposes worldwide. Many species are used for their antibacterial, antifungal, antiprotozoal, antiviral, antidiarrhoeal, analgesic, antimalarial, antioxidant, antiinflammatory and anticancer activities. Wound healing and cardiovascular effects have also been credited to some species. Many Terminalia species have multiple beneficial effects for multiple diseases and ailments. Indeed, the Indian species Terminalia chebula is known as the king of plants in Ayurveda due to its broad range of medicinal uses. However, apart from the reported ethnopharmacological uses of many Terminalia species, surprisingly few studies have rigorously examined this important genus for their medical properties/mechanisms and phytochemistry. This is likely due to the high tannin content common to many Terminalia species and the perception that these tannins may be responsible for much of their beneficial properties. As the complexities of tannins make them poor candidates for drug design, most interest in Terminalia species has been for their pharmacognostic and nutraceutical value and they have often been overlooked as potentials for drug discovery. However, recent reports have identified many other interesting phytochemicals and demonstrated that these may be responsible for several of the reported bioactivities of the Terminalia species used in traditional medicinal systems. The last decade has seen a large increase in the number of studies into the use of Terminalia species as therapeutic agents. Several species used in Ayurvedic medicine (Terminalia arjuna, Terminalia bellerica, Terminalia catappa, T. chebula) in particular have received much recent attention. Similarly, recent reports have also highlighted the medicinal potential of species from Africa, Australia and the Americas. The aim of this report is to summarise the recent research into the medicinal properties, phytochemistry and therapeutic mechanisms of Terminalia species and thus to highlight and direct future areas of research into the medicinal activities of this important genus.

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Section: Antidiabetic Activitymentioning

confidence: 84%

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

2015

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“…Kidney is an important organ to remove the metabolic wastes such as blood urea nitrogen (BUN) and creatinine from body, thereby helping to maintain body homeostasis of above mentioned substances (Ramachandran et al 2012). The results from Table 2 show that the extract administration could significantly decrease BUN, an indicator of renal function.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic activity of Helicteres angustifolia root

Cheng

Zhang

2016

Pharmaceutical Biology

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ContextThe root of Helicteres angustifolia L. (Sterculiaceae) has been used as folk herbal drug to treat cancer, bacterial infections, inflammatory, and flu in China. However, there is no report on its antidiabetic activity. Objective This study evaluates the antidiabetic activity of ethanol extract from H. angustifolia root. Materials and methods The promoting effect of H. angustifolia root ethanol extract (25, 50, and 100 mg/mL) on glucose uptake was evaluated using HepG2 cell, differentiated C2C12 myotubes, and differentiated 3T3-L1 adipocytes. The antidiabetic activity of the extract was assessed in vivo using STZ-induced diabetic rats by orally administration of the extract (200 and 400 mg/kg b.w.) once per day for 28 d. Blood glucose, TG, TC, TP, HDL-C, UA, BUN, AST, ALT, insulin, and HOMA-IR were analyzed. Results The results showed that the extract increased glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes with an IC 50 value of 79.95 and 135.96 mg/mL, respectively. And about 12%, 19%, and 10% (p 5 0.05) in HepG2 cells when compared with the control at the concentration of 25, 50, and 100 mg/mL, respectively. After 28 days' treatment with the extract, significant reduction was observed in blood glucose, HOMA-IR, TC, TG, UA, BUN, AST, and ALT levels, while the levels of TP and HDL cholesterol increased. Discussion and conclusion These results suggest that H. angustifolia root ethanol extract possess potent antidiabetic activity, which is the first report on antidiabetic activity of this plant.

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“…Group 5: diabetic rats received glibenclamide at 5 mg/kg dose [12]. AETPB dose was selected based on our previous study findings [11], and vehicle, AETPB, and glibenclamide were administered by rat oral needle to their respective group of rats up to 28 days. All samples (AETPB in water and glibenclamide in 0.2% CMC) were prepared freshly before the oral administration on each day.…”

Section: Methodsmentioning

confidence: 99%

“…The hepatoprotective and anti-inflammatory activity of its bark was reported [9, 10]. Previously, we have reported antidiabetic and antioxidant activity of Terminalia paniculata bark in type 1 diabetes [11]. But, till date, there is no scientific report available to support the antidiabetic activity of Terminalia paniculata bark in type 2 diabetes and also its mechanisms responsible for the antidiabetic activity.…”

Section: Introductionmentioning

confidence: 99%

In Vivo and In Vitro Antidiabetic Activity of Terminalia paniculata Bark: An Evaluation of Possible Phytoconstituents and Mechanisms for Blood Glucose Control in Diabetes

2013

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The present study was aimed to investigate in vivo, in vitro antidiabetic activity of aqueous extract of Terminalia paniculata bark (AETPB) and characterize its possible phytoconstituents responsible for the actions. Type 2 diabetes was induced in rats by streptozotocin-nicotinamide (65 mg/kg–110 mg/kg; i.p.) administration. Oral treatment of AETPB using rat oral needle at 100 and 200 mg/kg doses significantly (P < 0.001) decreased blood glucose and glycosylated haemoglobin levels in diabetic rats than diabetic control rats. AETPB-treated diabetic rats body weight, total protein, insulin, and haemoglobin levels were increased significantly (P < 0.001) than diabetic control rats. A significant (P < 0.001) reduction of total cholesterol and triglycerides and increase in high-density lipoprotein levels were observed in type 2 diabetic rats after AETPB administration. Presence of biomarkers gallic acid, ellagic acid, catechin, and epicatechin in AETPB was confirmed in HPLC analysis. AETPB and gallic acid showed significant (P < 0.001) enhancement of glucose uptake action in presence of insulin in muscle cells than vehicle control. Also AETPB inhibited pancreatic α-amylase and α-glucosidase enzymes. In conclusion, the above actions might be responsible for the antidiabetic activity of AETPB due to presence of gallic acid and other biomarkers.

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Investigation of hypoglycemic, hypolipidemic and antioxidant activities of aqueous extract of Terminalia paniculata bark in diabetic rats

Cited by 76 publications

References 31 publications

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae)

Antidiabetic activity of Helicteres angustifolia root

In Vivo and In Vitro Antidiabetic Activity of Terminalia paniculata Bark: An Evaluation of Possible Phytoconstituents and Mechanisms for Blood Glucose Control in Diabetes

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