Sphaeranthus indicus Linn.: A phytopharmacological review

Galani, Varsha J; Patel, Bharatkumar G; Rana, Digvijay G.

doi:10.4103/0974-7788.76790

Cited by 60 publications

(35 citation statements)

References 20 publications

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“…Results 3 . Another study reported that flower extract showed inhibition against Gram-positive bacteria such as B. subtilis, Staph.…”

Section: Resultsmentioning

confidence: 98%

“…Earlier literature survey reveals the presence of various phyto components isolated from various parts of S. indicus such as alkaloid sphaeranthine 2 , a bicyclic sesquiterpene lactone from petroleum ether extract 3 and flavanoid C-glycoside; 5-hydroxy-7-methoxy-6-C-glycosyl flavone has been isolated from the aerial part of S. indicus 4 . A flavone glycoside, 7-hydroxy-3',4',5,6-tetramethoxy-flavone 7-O-β-d-(1-4)-diglucoside, from the stem of S. indicus 5 .…”

Section: Introductionmentioning

confidence: 99%

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In vitroAntioxidant and Antimicrobial Activities ofSphaeranthus indicusL.

Kavitha

Satish

2015

Journal of Biologically Active Products from Nature

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The present study evaluates the phytochemical profile, antioxidant and antimicrobial activities of Sphaeranthus indicus. The presence of phytochemical constituents of S. indicus was tested using standard procedures. Antimicrobial assay was evaluated using agar well diffusion method and antioxidant assays such as DPPH, ABTS and FRAP were tested for four different test solvent extracts of S. indicus. Phytochemical analysis revealed the presence of alkaloids, carbohydrates, flavanoids and phytosterols. Antioxidant assays i.e., DPPH scavenging activity of solvent extracts showed IC 50 value of 224.82, 173.41,135.36 and 296.46 μg/ ml and ABTS assay resulted with IC 50 of 198.08, 157.88, 127.51 and 234.67 μg/ml respectively. Ethyl acetate extract also showed significant reducing activity followed by other test solvent extracts. Antibacterial activity exhibited significant activity with petroleum ether extract against B. subtilis, Kl. pneumoniae, Pr. mirabilis, Salm. typhimurium and Staph. epidermidis with least MIC at 0.07 mg/ml. Chloroform extract showed significant activity against Kl. pneumoniae, Salm. typhimurium and Staph. epidermidis with MIC of 0.15-0.3 mg/ml. Ethyl acetate extract showed significant activity with MIC of 0.07 mg/ml against Kl. pneumoniae whereas methanol extract exhibited moderate to least activity against test bacteria with MIC value ranging from 0.31-5 mg/ml. All the test solvent extracts exhibited significant activity against Microsporum canis with MIC 0.07 mg/ml compared to standard antibiotic. Candida albicans was significantly inhibited only in petroleum ether extract. The promising results obtained from the study indicates that S. indicus would be potent candidate for further isolation and characterization of bioactive compound which might be attributed to the significant bioactivities.

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“…Results 3 . Another study reported that flower extract showed inhibition against Gram-positive bacteria such as B. subtilis, Staph.…”

Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

In vitroAntioxidant and Antimicrobial Activities ofSphaeranthus indicusL.

Kavitha

Satish

2015

Journal of Biologically Active Products from Nature

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“…Many herbs and higher plants containing sesquiterpenoids have been exploited in traditional medicine since ancient times (Galani et al 2010;Chu et al 2011;Sauter et al 2011). The derivatives of sesquiterpenes are considered as bioactive substances with desirable fragrance and flavoring properties (Fraga 2006;Edris 2007).…”

Section: Introductionmentioning

confidence: 99%

CYP264B1 from Sorangium cellulosum So ce56: a fascinating norisoprenoid and sesquiterpene hydroxylase

Khatri

Zapp

et al. 2012

Appl Microbiol Biotechnol

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Many terpenes and terpenoid compounds are known as bioactive substances with desirable fragrance and medicinal activities. Modification of such compounds to yield new derivatives with desired properties is particularly attractive. Cytochrome P450 monooxygenases are potential enzymes for these reactions due to their capability of performing different reactions on a variety of substrates. We report here the characterization of CYP264B1 from Sorangium cellulosum So ce56 as a novel sesquiterpene hydroxylase. CYP264B1 was able to convert various sesquiterpenes including nootkatone and norisoprenoids (α-ionone and β-ionone). Nootkatone, an important grapefruit aromatic sesquiterpenoid, was hydroxylated mainly at position C-13. The product has been shown to have the highest antiproliferative activity compared with other nootkatone derivatives. In addition, CYP264B1 was found to hydroxylate α- and β-ionone, important aroma compounds of floral scents, regioselectively at position C-3. The products, 3-hydroxy-β-ionone and 13-hydroxy-nootkatone, were confirmed by (1)H and (13)C NMR. The kinetics of the product formation was analyzed by high-performance liquid chromatography, and the K ( m ) and k (cat) values were calculated. The results of docking α-/β-ionone and nootkatone into a homology model of CYP264B1 revealed insights into the structural basis of these selective hydroxylations.

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“…As flowering head of S. indicus is used in traditional as analgesic [23]. This study was conducted to validate folkloric uses of the flowers of plant by traditional healer.…”

Section: Discussionmentioning

confidence: 99%

Topical Analgesic Activity of Essential Oil Extracted From Spharenthus Indicus (Asteraceae)

Padhan¹,

Sriballav²,

Arnabaditya³

2017

Asian J Pharm Clin Res

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Objective: The objective of this study was to evaluate the topical analgesic effects of essential oil extracted from Sphaeranthus indicus (Asteraceae). Methods:The essential oil was extracted from fresh flower of S. indicus. Topical ointment containing essential oil was investigated for analgesic activity in rat using hot-plate method. Diclofenac sodium gel was taken as standard drug. Result:The analgesic activity of topical preparation was observed in the early phase. The analgesic activity of topical preparation containing 2% S. indicus flower essential oil showed significant activity (11.5±0.34 and 11.83±0.40) comparative to standard drug diclofenac sodium (11.83±0.31 and 12.66±0.61) at 90 and 120 minutes of application of drug by hot-plate method (p<0.001). Conclusion:Hence, the study validates the traditional use of S. indicus to relive pain.

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Sphaeranthus indicus Linn.: A phytopharmacological review

Cited by 60 publications

References 20 publications

In vitroAntioxidant and Antimicrobial Activities ofSphaeranthus indicusL.

In vitroAntioxidant and Antimicrobial Activities ofSphaeranthus indicusL.

CYP264B1 from Sorangium cellulosum So ce56: a fascinating norisoprenoid and sesquiterpene hydroxylase

Topical Analgesic Activity of Essential Oil Extracted From Spharenthus Indicus (Asteraceae)

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