Topical Analgesic Activity of Essential Oil Extracted From Spharenthus Indicus (Asteraceae)

Abstract

Objective: The objective of this study was to evaluate the topical analgesic effects of essential oil extracted from Sphaeranthus indicus (Asteraceae). Methods:The essential oil was extracted from fresh flower of S. indicus. Topical ointment containing essential oil was investigated for analgesic activity in rat using hot-plate method. Diclofenac sodium gel was taken as standard drug. Result:The analgesic activity of topical preparation was observed in the early phase. The analgesic activity of topical preparation containing 2% S. indicus flower essential oil showed significant activity (11.5±0.34 and 11.83±0.40) comparative to standard drug diclofenac sodium (11.83±0.31 and 12.66±0.61) at 90 and 120 minutes of application of drug by hot-plate method (p<0.001). Conclusion:Hence, the study validates the traditional use of S. indicus to relive pain.

Essential Oils High in 1,8-Cineole of Mediterranean Flavoring Plants: Health Benefits

“…Some studies carried out in animal models with terpenes present in EOs, such as linalool, limonene, myrcene, 1,8-cineole, demonstrated that these compounds showed analgesic activity [143][144][145][146][147][148][149][150][151][152]. The analgesic and anti-inflammatory potential of OEs are preferentially attributed to the high content of terpene compounds [143,145,146,[153][154][155][156] as well as to the synergetic effect of minor components that can influence the pharmacokinetics and bioavailability of compounds with pharmacological action [157].…”