Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

Abdel-Moneim, Adel; El‐Twab, Sanaa M. Abd; Ashour, Mohamed B.; Yousef, Ahmed I.

doi:10.21746/ijbio.2016.06.0011

Cited by 14 publications

(5 citation statements)

References 64 publications

(49 reference statements)

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“…In agreement with Gupta et al (2011) and Moneim et al, (2016) the untreated diabetic models showed a highly significant increase in protein level in urine compared with the control group. High proteinuria may be as a result of increased advanced oxidative protein products, reactive oxygen species and free radicals producing protein carbonyl products and due to increasing the permeability of the glomerular membrane (Madianov et al 2000).…”

Section: The Mean Alpha Sma Stained Area Percentagesupporting

confidence: 91%

Dapagliflozin Versus Insulin: Which Is Better in Treatment of Diabetic Nephropathy in Albino Rats, Immunohistochemical Study

Ahmed

Gabr

Shams

et al. 2022

Egyptian Academic Journal of Biological Sciences, D. Histology

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Diabetes mellitus is a chronic disease of two types: type I diabetes mellitus (T1DM) which results from insulin deficiency and type II diabetes mellitus (T2DM) which results from insulin resistance leading to hyperglycemia (Rosen et al., 2001). Diabetes mellitus is mostly called 'The silent killer' as it causes major complications without major symptoms and can affect many important organs in the body (Rang et al., 1991).

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Section: The Mean Alpha Sma Stained Area Percentagesupporting

confidence: 91%

Dapagliflozin Versus Insulin: Which Is Better in Treatment of Diabetic Nephropathy in Albino Rats, Immunohistochemical Study

Ahmed

Gabr

Shams

et al. 2022

Egyptian Academic Journal of Biological Sciences, D. Histology

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“…Consequently, the activities of liver damage markers of ALT and AST enzymes increased in the untreated diabetic patients [132,133]. These data run in parallel with the results of Ahmed et al [95] and Moneim et al [134]. The C. reticulata peel hydroethanolic extract, hesperidin, and quercetin have a defensive effect against the hepatotoxicity produced by STZ-induced DM; their effects are nearly similar.…”

supporting

confidence: 84%

Antidiabetic Potency, Antioxidant Effects, and Mode of Actions ofCitrus reticulataFruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats

Ali

Abdel‐Gabbar

Abdel-Twab

et al. 2020

Oxidative Medicine and Cellular Longevity

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This study is aimed at assessing the antihyperglycemic, antihyperlipidemic, and antioxidant effects of Citrus reticulata (C. reticulata) fruit peel hydroethanolic extract and two flavonoids, hesperidin and quercetin, in nicotinamide (NA)/streptozotocin- (STZ-) induced type 2 diabetic rats. In addition, GC-MS and HPLC-MS analyses of the extract were performed and the results indicated the presence of multiple flavonoids including hesperidin, quercetin, naringin, and polymethoxylated flavones (nobiletin and tangeretin). To achieve the aim of the study, diabetic rats with NA/STZ-induced T2DM were orally treated with C. reticulata fruit peel hydroethanolic extract, hesperidin, and quercetin at a dose of 100 mg/kg b.w./day for four weeks. The treatments with C. reticulata fruit peel extract, hesperidin, and quercetin significantly ameliorated the impaired oral glucose tolerance; the elevated serum fructosamine level; the diminished serum insulin and C-peptide levels; the altered HOMA-IR, HOMA-IS, and HOMA-β cell function; the decreased liver glycogen content; the increased liver glucose-6-phosphatase and glycogen phosphorylase activities; the deleteriously affected serum lipid profile; the elevated serum AST and ALT activities; and the raised serum creatinine and urea levels in the diabetic rats. The treatments also produced remarkable improvement in the antioxidant defense system manifested by a decrease in the elevated liver lipid peroxidation and an increase in the lowered glutathione content and GPx, GST, and SOD activities. Furthermore, the three treatments enhanced the mRNA expression of GLUT-4 and the insulin receptor β-subunit, but only quercetin produced a significant increase in the expression of adiponectin in adipose tissue of diabetic rats. In conclusion, C. reticulata fruit peel hydroethanolic extract, hesperidin, and quercetin have potent antidiabetic effects which may be mediated through their insulinotropic effects and insulin-sensitizing actions. In addition, the alleviation of the antioxidant defense system by the extract, hesperidin, and naringin may have an important action to enhance the antidiabetic actions and to improve liver and kidney functions in NA/STZ-induced diabetic rats.

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“…In the present study, ALT and AST activities in the toluene+p-CA group were significantly (p<0.05) higher than in the toluene group. Similar to the present study, p-CA in serum samples decreased ALT and AST activities, and cretainine level (41,42,43,44).…”

Section: Discussionsupporting

confidence: 89%

The protective effect of p-coumaric acid on toluene-induced hepatotoxicity, nephrotoxicity and neurotoxicity in rats

Sahindokuyucu-Kocasari

Erdemli-Köse

Erol

et al. 2021

Rev Colombiana Cienc Anim. RECIA

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Objective. The aim of this study was to determine the protective effect of p-coumaric acid (p-CA) against toluene-induced hepatotoxicity, nephrotoxicity and neurotoxicity in rats. Materials and methods. A total of 32 Sprague-Dawley male rats, 8 in each group, were used. 4 groups were formed as control, toluene, p-CA and toluene+p-CA. Animals in the control group, toluene group and p-CA group were given 0.9% NaCl, 0.9 mg/kg b.w toluene and 100 mg/kg b.w p-CA orally for 21 days, respectively. The animals in toluene+p-CA group were received p-CA for 3 days and from day 4, toluene and p-CA were applied together daily until day 25. On the 25th day, the study was terminated, blood and tissue samples were collected. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatinine levels in serum, glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) and glutathione (GSH) levels in the tissue samples were determined. Results. In this study, it was determined that there were significant increases in ALT and AST activities, and creatinine levels in toluene-induced group compared to control group. Moreover, there was a decrease in the GSH-Px activities and GSH levels, and an increase in the MDA levels compared to the control group. However, in the toluene+p-CA group, significant decreases in aminotransferases activities, creatinine and MDA levels, and significant increases in GSH-Px activities and GSH levels were determined compared to the toluene group. Conclusions. It has been determined that p-CA has a protective effect against toluene-induced hepatotoxicity, nephrotoxicity and neurotoxicity.

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Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

Cited by 14 publications

References 64 publications

Dapagliflozin Versus Insulin: Which Is Better in Treatment of Diabetic Nephropathy in Albino Rats, Immunohistochemical Study

Dapagliflozin Versus Insulin: Which Is Better in Treatment of Diabetic Nephropathy in Albino Rats, Immunohistochemical Study

Antidiabetic Potency, Antioxidant Effects, and Mode of Actions ofCitrus reticulataFruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats

The protective effect of p-coumaric acid on toluene-induced hepatotoxicity, nephrotoxicity and neurotoxicity in rats

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