Antidiabetic, antihyperlipidemic and in vivo antioxidant potential of aqueous extract of Anogeissus latifolia bark in type 2 diabetic rats

Ramachandran, Subramaniam; Naveen, Koikaramparambil Robert; Rajinikanth, B.; Akbar, Mohammad Ahsanul; Rajasekaran, A.

doi:10.1016/s2222-1808(12)60229-1

Cited by 21 publications

(13 citation statements)

References 18 publications

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“…This may be due to inhibition of proteolysis or enhancement of protein synthesis. [22] Similar observations were reported using Acacia melanoxylon linen seed extract in diabetic rats. [23]…”

Section: Total Proteinsupporting

confidence: 76%

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Ramesh¹

2018

IJGP

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Aim: The aim of the present study was to evaluate the antihyperglycemic and antihyperlipidemic activities of hydroethanolic extract of Acacia catechu (L.f) Willd leaf in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Diabetic rats were treated with oral administration of hydroethanolic leaf extract of A. catechu (L.f) Willd (200 mg/kg and 400 mg/kg) for 30 days. Various biochemical parameters such as serum glucose, protein, urea, creatinine, lipid profile, and activities of liver and kidney marker enzymes were measured to assess the antihyperglycemic and antihyperlipidemic activities of the extract. Results and Discussion: Administration of the hydroethanolic leaf extract of A. catechu (L.f) Willd (200 mg/kg and 400 mg/kg) significantly decreased (P < 0.05; P < 0.01) blood glucose levels in diabetic rats and has the capacity to correct the metabolic disturbances associated with diabetes. Further, the extract decreased total cholesterol, triglycerides, low-density lipoprotein (LDL), very LDL (VLDL) levels, and increased high-density lipoprotein levels. Conclusion: The present investigation suggested that the administration of A. catechu (L.f) Willd exhibited antidiabetic activity in STZ-induced diabetic rats and could be considered for further evaluation in drug development.

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Section: Total Proteinsupporting

confidence: 76%

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Ramesh¹

2018

IJGP

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“…Crude extract of Anogeissus acuminata has been screened for its anti-HIV, antioxidant, antibacterial, antidiabetic and thrombolytic activities [19][20][21][22]25]. Other species of the Anogeissus family are traditionally famous for their diuretic, hypolipidemic and cardiovascular diseases treatment potential [11,26]. High performance thin layer chromatography (HPTLC) fingerprinting phytochemically reported studies of Anogeissus acuminata revealed the presence of flavonoids, phenols and tannins in abundance [11].…”

Section: Discussionmentioning

confidence: 99%

Studies to Elucidate the Mechanism of Cardio Protective and Hypotensive Activities of Anogeissus acuminata (Roxb. ex DC.) in Rodents

et al. 2020

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Anogeissus acuminata (Roxb. ex DC.) is a folkloric medicinal plant in Asia; including Pakistan; used as a traditional remedy for cardiovascular disorders. This study was planned to establish a pharmacological basis for the trivial uses of Anogeissus acuminata in certain medical conditions related to cardiovascular systems and to explore the underlying mechanisms. Mechanistic studies suggested that crude extract of Anogeissus acuminata (Aa.Cr) produced in vitro cardio-relaxant and vasorelaxant effects in isolated paired atria and aorta coupled with in vivo decrease in blood pressure by invasive method; using pressure and force transducers connected to Power Lab Data Acquisition System. Moreover; Aa.Cr showed positive effects in left ventricular hypertrophy in Sprague Dawley rats observed hemodynamically by a decrease in cardiac cell size and fibrosis; along with absence of inflammatory cells; coupled with reduced levels of angiotensin converting enzyme (ACE) and renin concentration along with increased concentrations of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP). In Acute Myocardial Infarction (AMI) model; creatine kinase (CK), creatine kinase-MB (CK-MB) and lactic acid dehydrogenase (LDH levels) were found to be decreased; along with decreased necrosis; edema and recruitment of inflammatory cells histologically. In vivo and ex vivo studies of Anogeissus acuminata provided evidence of vasorelaxant; hypotensive and cardioprotective properties facilitated through blockage of voltage-gated Ca++ ion channel; validating its use in cardiovascular diseases

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“…The level of lipid peroxidation (TBARS) and reactive oxygen species are common markers of oxidative stress. Malondialdehyde (MDA) is one of the end products of lipid peroxidation [ 27 ]. Our results showed that C. odorata and J. regia extracts significantly decreased MDA levels in diabetic and hypercholesterolemic animals, probably due to the bioactive compounds with antioxidant activity present in the extracts.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological and Genotoxic Properties of Polyphenolic Extracts ofCedrela odorataL. andJuglans regiaL. Barks in Rodents

Almonte-Flores¹,

Paniagua-Castro

Escalona-Cardoso

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Evaluation of the phenolic compounds and antioxidant activity of Cedrela odorata L. and Juglans regia L. bark extracts was performed in vitro. Juglans regia showed greater extract concentration and higher antioxidant activity. Hypoglycemic activity in rats was assessed by generating a glucose tolerance curve and determining the area under the curve (AUC). Diabetes was later induced by an injection with streptozotocin (65 mg/kg of b.w.) and confirmed after 24 hours. The extract was administered (200 mg/kg b.w.) over 10 days, and blood glucose was monitored and compared with a control group. The glucose AUC showed a hypoglycemic effect of J. regia and C. odorata in normal rats. Both extracts reduced hepatic lipid peroxidation in diabetic rats. Polyphenolic extracts reduced cholesterol levels in a hypercholesterolemic mouse model and decreased hepatic lipid peroxidation. Polyphenolic extract doses of 100 and 200 mg/kg b.w. were administered alone or with cyclophosphamide (CPA) 50 mg/kg ip, which was used as a positive control. Analyses were performed using leukocytes in a comet assay after 4 and 24 h of treatment. Genotoxic effects were evaluated by the comet assay, which showed that while J. regia extract had no effect, C. odorata extract induced slight damage at 200 mg/kg, with the formation of type 0 and 1 comets.

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Antidiabetic, antihyperlipidemic and in vivo antioxidant potential of aqueous extract of Anogeissus latifolia bark in type 2 diabetic rats

Cited by 21 publications

References 18 publications

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Studies to Elucidate the Mechanism of Cardio Protective and Hypotensive Activities of Anogeissus acuminata (Roxb. ex DC.) in Rodents

Pharmacological and Genotoxic Properties of Polyphenolic Extracts ofCedrela odorataL. andJuglans regiaL. Barks in Rodents

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