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Abstract

Aim: The aim of the present study was to evaluate the antihyperglycemic and antihyperlipidemic activities of hydroethanolic extract of Acacia catechu (L.f) Willd leaf in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Diabetic rats were treated with oral administration of hydroethanolic leaf extract of A. catechu (L.f) Willd (200 mg/kg and 400 mg/kg) for 30 days. Various biochemical parameters such as serum glucose, protein, urea, creatinine, lipid profile, and activities of liver and kidney marker enzymes were measured to assess the antihyperglycemic and antihyperlipidemic activities of the extract. Results and Discussion: Administration of the hydroethanolic leaf extract of A. catechu (L.f) Willd (200 mg/kg and 400 mg/kg) significantly decreased (P < 0.05; P < 0.01) blood glucose levels in diabetic rats and has the capacity to correct the metabolic disturbances associated with diabetes. Further, the extract decreased total cholesterol, triglycerides, low-density lipoprotein (LDL), very LDL (VLDL) levels, and increased high-density lipoprotein levels. Conclusion: The present investigation suggested that the administration of A. catechu (L.f) Willd exhibited antidiabetic activity in STZ-induced diabetic rats and could be considered for further evaluation in drug development.

Acacia catechu (L.f.) Willd.: A Review on Bioactive Compounds and Their Health Promoting Functionalities

“…The results indicate that the extract lowered blood glucose levels significantly. The activity of Aspartate aminotransferase, Alanine aminotransferase, and alkaline phosphatase in group III and group IV was found to be considerably decreased in rats as compared with the control group (Table 4) [12]. In diabetic rats, A. ataxacantha root extracts considerably reduced the activities of AST, ALT, and ALP [63].…”

“…Upon comparison of the diabetic to the normal rats, the amount of HDL serum was considerably lower. The flavonoids in the plant extract are responsible for boosting HDL levels [12]. The root extract of A. ataxacantha improved serum HDL levels and effectively reduced triglyceride serum, total cholesterol, VLDL, and LDL [63].…”

“…In addition, catechin is also the name of the chemical family for all the compounds that are derived from catechin [7]. Numerous researchers have studied the pharmacological properties of extracts made from different parts of A. catechu (involving heartwood, bark, leaves, seeds, and pods) in recent years [8][9][10][11][12][13] (Figure 2). Different parts of A. catechu are depicted in Figure 1.…”

“…Different parts of A. catechu are depicted in Figure 1. The extract of A. catechu also exhibits numerous pharmacological activities, including immunomodulators [9,10], anti-hyperglycemic [11,12], antinociceptive [11], antihyperlipidemic [12], and antiulcer [13]. The flavonoids found in the hardwood of A. catechu have been utilized in a range of pharmaceutical activities, particularly in Asia, such as antibacterial, anti-cancer, anti-inflammatory, anti-viral, and cardiovascular reasons [14,15].…”