Antidepressant‐like effect of riparin II from Aniba riparia in mice: evidence for the involvement of the monoaminergic system

Abstract

In a previous study conducted by our group, riparin II (ripII) isolated from the green fruit of Aniba riparia presented antianxiety effects in mice. This study investigates a possible antidepressant activity of rip II using two predictive tests for antidepressant activity in rodents: the forced swimming test (FST) and tail suspension test (TST). Additionally, the mechanisms involved in the antidepressant-like effect in mice were also assessed. Rip II was acute administered by intraperitoneal (i.p.) and oral (p.o) routes to male mice at doses of 25 and 50 mg/kg. Results showed that ripII at both tested doses and administration routes produced a significant decrease of immobility time in FST and TST. The pretreatment of mice with prazosin (1 mg/kg, i.p., an α1-adrenoceptor antagonist), SCH23390 (15 μg/kg, i.p., a dopamine D1 receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine D2 receptor antagonist), p-chlorophenylalanine (100 mg/kg, an inhibitor of serotonin synthesis), or NAN-190 (0.5 mg/kg, a serotonin 5-HT1A receptor antagonist) completely blocked the anti-immobility effects elicited by riparin II (50 mg/kg, p.o.) in the FST. This study indicates that riparin II produces significant antidepressant-like activity in the forced swimming and TSTs, and this effect seems to be dependent on its interaction with noradrenergic, dopaminergic, and serotonergic systems.

Involvement of monoaminergic system in the antidepressant‐like effect of riparin I from Aniba riparia (Nees) Mez (Lauraceae) in mice

“…Significant difference compared with control (***P < 0.001), rip I-50 ( aaa P < 0.001) and fluoxetine-35 ( bb P < 0.01; bbb P < 0.001). Our results support literature data indicating that both dopamine D1 and D2 receptors might play a role in depression [6,30,31]. In this context, we investigated the possible involvement of these systems in the anti-immobility effect of rip I (50 mg/kg, p.o.)…”

“…In this sense, recent studies conducted by our group provided evidence for the involvement of the serotonergic, noradrenergic and dopaminergic systems in the antidepressant-like action of rip II [6] and rip III [13]. In this sense, recent studies conducted by our group provided evidence for the involvement of the serotonergic, noradrenergic and dopaminergic systems in the antidepressant-like action of rip II [6] and rip III [13].…”

“…In previous studies carried out by our group [6,[8][9][10], riparin I (rip I) analogs, riparin II (rip II) and riparin III (rip III) exhibited antianxiety and antidepressant-like activities in mice. However, as far as we know, antidepressant-like properties from rip I are still unknown in literature.…”

“…In this context, natural plants may be an important source of new antidepressant drugs once there are plenty works showing the effectiveness of some herbals extracts and their constituents against depression, such as Rosmarinus officinalis, Ginkgo biloba and Aniba riparia [4][5][6].…”

In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae)

“…Riparins possess anxiolytic, antidepressant, anticonvulsant, antimicrobial and myorelaxing action. Natural riparins n-benzoyl tyramine (riparin I), n-(-2-hydroxybenzoyl) tyramine (riparin II) and n-(2,6-dihydroxybenzoyl) tyramine (riparin III) have been isolated from an unripe fruit of Aniba riparia, a plant of typical occurrence in the Amazon region, popularly known as "louro" (Catão et al 2005;Teixeira et al 2013).…”