Involvement of the GABAergic system in the anxiolytic effect of sulfated polysaccharides from the red seaweed Gracilaria cornea

Monteiro, Valdécio Silvano; Teles, Felipe Barros; Coura, Chistiane Oliveira; Souza, Ricardo Basto; Lima, Camila Nayane de Carvalho; Costa, Deiziane Viana da Silva; Honório, Eduardo Ribeiro; Escudeiro, Sarah de Souza; Chaves, Edna Maria Camelo; Vasconcelos, Silvânia Maria Mendes; Benevídes, Norma Maria Barros

doi:10.1007/s10811-015-0724-0

Cited by 9 publications

(2 citation statements)

References 38 publications

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“…Marine algae have attracted special interest as good sources of sulphated polysaccharides (SP) and have a range of uses in the food, cosmetics and pharmaceutical industries and in biotechnology . Previous studies from our group demonstrated certain biological activities of SP, such as anticoagulant , antithrombotic , antimicrobial , antioxidant , anxiolytic , antinociceptive and anti‐inflammatory activities. Furthermore, toxicological studies have reported that SP are well tolerated in experimental animals .…”

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confidence: 99%

Neuroprotective Effects of Sulphated Agaran from Marine Alga Gracilaria cornea in Rat 6‐Hydroxydopamine Parkinson's Disease Model: Behavioural, Neurochemical and Transcriptional Alterations

Souza

Frota

Sousa

et al. 2016

Basic Clin Pharma Tox

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Parkinson's disease (PD) is a multifactorial disease associated with the degeneration of dopaminergic neurons and behavioural alterations. Natural bioactive compounds may provide new therapeutic alternatives for neurodegenerative disorders, such as PD. The sulphated polysaccharides isolated from marine algae are heterogenic molecules that show different biological activities. The red marine alga Gracilaria cornea has a sulphated polysaccharide (SA-Gc) with structure and anti-inflammatory and antinociceptive activities reported in the literature. Therefore, this study aimed to evaluate the neuroprotective effects of SA-Gc in rat model PD induced by 6-hydroxydopamine (6-OHDA). Firstly, we established the PD model in rats, induced by an intrastriatal injection (int.) of 6-OHDA, followed by a single administration of SA-Gc (15, 30 or 60 μg; int.). On the 14th day, behavioural tests were performed. After killing, brain areas were dissected and used for neurochemical and/or transcriptional analyses. The results showed that SA-Gc (60 μg, int.) promoted neuroprotective effects in vivo through reducing the oxidative/nitroactive stress and through alterations in the monoamine contents induced by 6-OHDA. Furthermore, SA-Gc modulated the transcription of neuroprotective and inflammatory genes, as well as returning behavioural activities and weight gain to normal conditions. Thus, this study reports the neuroprotective effects of SA-Gc against 6-OHDA in rats.

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confidence: 99%

Neuroprotective Effects of Sulphated Agaran from Marine Alga Gracilaria cornea in Rat 6‐Hydroxydopamine Parkinson's Disease Model: Behavioural, Neurochemical and Transcriptional Alterations

Souza

Frota

Sousa

et al. 2016

Basic Clin Pharma Tox

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“…Previous studies have demonstrated in vitro and in vivo activities of SGs obtained from red seaweeds species, including agaran-type from Gracilaria cornea and Gracilaria birdiae (Usov, 2011) and carrageenan-type from Solieria filiformis (Robledo & Freire-Pleegrin, 2010). The biological activities include modulation of pain and inflammation (Coura et al, 2012), neuroprotective activity (Souza et al, 2016) anxiolytic (Monteiro et al, 2016), anticoagulant (Rodrigues et al, 2010), and antiviral effects (Morán-Santibañez et al, 2016). In this study we evaluated the activation and phenotype of murine macrophages RAW 264.7 incubated with SGs from red seaweeds G. cornea, G. birdiae and S. filiformis.…”

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confidence: 99%

Sulfated agarans from red seaweed Gracilaria cornea induce macrophages polarization to an antitumor M1 phenotype

Anb

et al. 2021

Preprint

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Marine seaweeds are a rich source of sulfated polysaccharides (SPs) with several biological activities, including antitumor effect. Some polysaccharides are also described to activate macrophages (MΦs) to an antitumor M1-like phenotype. Here, we evaluated the capacity of SPs extracts obtained from three seaweed species, Gracilaria cornea (Gc-E), Gracilaria birdiae (Gb-E), and Solieria filiformis (Sf-E), to activate the MΦs antitumor M1 phenotype. The nitric oxide production, MHCII, and CD86 M1 markers were evaluated to screening the bioactive SPs profile on murine MΦs (RAW 264.7 cells). The direct SPs antiproliferative effect was tested on melanoma B16-F10 cells. In another experimental setting, B16-F10 cells were incubated with a conditioned medium obtained from MΦs exposed to SPs. The three SPs tested induced NO release. Sf-E directly inhibited B16-F10 cells proliferation compared with the saline group, but Gc-E and Gb-E failed to inhibit cell proliferation. Notably, a conditioned medium (CM) of MΦs incubated with Gc-E and Sf-E, but not of Gb-E, inhibited the proliferation of B16-F10 cells. Gc-E also induced TNF-α release and increase of M1 markers such as iNOS, MHCII, and CD86. Therefore, Gc-E activates a macrophage M1 phenotype, which in turn releases a factor that inhibits B16-F10 proliferation.

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A comprehensive review of traditional uses, bioactivity potential, and chemical diversity of the genus Gracilaria (Gracilariales, Rhodophyta)

et al. 2019

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Involvement of the GABAergic system in the anxiolytic effect of sulfated polysaccharides from the red seaweed Gracilaria cornea

Cited by 9 publications

References 38 publications

Neuroprotective Effects of Sulphated Agaran from Marine Alga Gracilaria cornea in Rat 6‐Hydroxydopamine Parkinson's Disease Model: Behavioural, Neurochemical and Transcriptional Alterations

Neuroprotective Effects of Sulphated Agaran from Marine Alga Gracilaria cornea in Rat 6‐Hydroxydopamine Parkinson's Disease Model: Behavioural, Neurochemical and Transcriptional Alterations

Sulfated agarans from red seaweed Gracilaria cornea induce macrophages polarization to an antitumor M1 phenotype

A comprehensive review of traditional uses, bioactivity potential, and chemical diversity of the genus Gracilaria (Gracilariales, Rhodophyta)

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