In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae)

Araújo, Éverton José Ferreira de; Lima, Layana Karine Farias; Silva, Oskar Almeida; Júnior, Luís Mário Rezende; Gutierrez, Stanley Juan Chávez; Carvalho, Fernando Aécio de Amorim; Lima, Francisco das Chagas Alves; Pessoa, Cláudia; Freitas, Rivelilson Mendes de; Ferreira, Paulo Michel Pinheiro

doi:10.1590/1809-4392201505436

Cited by 19 publications

(11 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Values of 50% effective concentration (EC 50 ) for Buriti extracts were spectrophotometrically quantified (T80+ UV/VIS Spectrometer, PG Instruments Ltd.®, Leicestershire, UK) at 515 nm for DPPH ∙ , 734 nm for ABTS ∙ + , 700 nm for potassium ferricyanide, 532 nm for TBARS (thiobarbituric acid reactive substances), and 540 nm for nitrite radicals 30 min after the reaction started. Antioxidant evaluation was performed in triplicate from two independent experiments and absorbance values were converted to the inhibition percentage (I) of radicals using the equation of [ 37 ]: (%) = [(absorbance of negative control − absorbance of sample) × 100]/absorbance of negative control, where absorbance of negative control is, for example, the initial absorbance for DPPH ∙ solution and absorbance of sample is the absorbance for reaction mixture (DPPH ∙ and sample).…”

Section: Methodsmentioning

confidence: 99%

In Vitro and Ex Vivo Chemopreventive Action of Mauritia flexuosa Products

Pereira-Freire

Oliveira

Lima

et al. 2018

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Mauritia flexuosa (Arecaceae), known as “Buriti,” is a Brazilian palm tree with high economic potential for local communities. Herein, we investigated the phytochemistry profile and antioxidant potential of M. flexuosa fruits and determined the bioaccessibility of phenolic compounds. Peels revealed upper values for phenols, flavonoids, carotenoids, tannins, and ascorbic acid when compared to the pulps and endocarps. All samples showed capacity to scavenger free radicals (0.5, 1.0, 2.0, 4.0, and 8.0 mg/mL) but peels presented higher scavenger action in all methods explored. Phenolic compounds identified by HPLC displayed reduced bioaccessibility after in vitro simulated gastrointestinal digestion for pulp (38.7%), peel (18.7%), and endocarp (22.3%) extracts (P < 0.05). Buriti fruits also protected rat blood cells against lysis induced by peroxyl radicals. We demonstrated the promising chemopreventive potentialities of M. flexuosa fruits and their by-products and peels with higher quantities of bioactive compounds and phenolic substances before and after in vitro bioaccessibility investigation. In Brazil, these parts are discarded or underused, mainly as feed for ruminant animals. Consequently, it is extremely important to explore nutritional characteristics of these by-products for human/livestock foods and to install biofriendly techniques and sustainable biotechnology handling of natural resources.

show abstract

Section: Methodsmentioning

confidence: 99%

In Vitro and Ex Vivo Chemopreventive Action of Mauritia flexuosa Products

Pereira-Freire

Oliveira

Lima

et al. 2018

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Importantes atividades e efeitos farmacológicos foram pesquisados, tendo resultados promissores elucidados, conforme a Tabela 2. A Rip-A mostrou um potencial antibacteriano modulador, propriedades antiinflamatórias, antinociceptivo, ansiolítica, antioxidante, antitumoral e leishmanicida (Araújo et al, 2016(Araújo et al, , 2018Costa et al, 2016;Nunes et al, 2014Nunes et al, , 2015Silva et al, 2015).…”

Section: Resultsunclassified

“…Diversos efeitos biológicos já foram elucidados utilizando tanto extratos de frutos e cálices, como dos constituintes isolados e análogos sintéticos. Ação antitumoral e leishmanicida (Araújo et al, 2016), em outro estudo evidenciou-se propriedades antitumorais apresentando taxas de inibição do crescimento celular superiores a 70% (Nunes et al, 2014), efeitos antinociceptivos (Nascimento et al, 2016), potencialidades do uso das riparina no tratamento de doenças neurodegerativas e Research, Society and Development, v. 10, n. 16, e328101623510, 2021 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v10i16.23510 3 inflamatórias. Pois, demonstrou ação neuroprotetora (Nunes et al, 2015), efeito antioxidante, diminuindo a produção de citocinas pró-inflamatórias e do estresse oxidativo (Silva et al, 2015), efeito bactericida para algumas bactérias Gram-positivas e Gramnegativas, fungicida contra Candida spp.…”

Section: Introductionunclassified

Potencial bioativo dos análogos sintéticos das riparinas: uma revisão sistemática

Gomes

Araujo

Silva

et al. 2021

RSD

Self Cite

View full text Add to dashboard Cite

Objetivo: Realizar uma revisão sistemática dos estudos com os análogos sintéticos da Aniba riparia, as riparinas A, B, C, D, E e F, com o intuito de evidenciar os potenciais farmacológicos já elucidados. Metodologia: Utilizou-se três bases de dados para seleção dos artigos a serem incluídos na revisão Embase, Pubmed e Web of Science, com a seguinte estratégia de busca simplificada (Riparin or Aniba riparia), ao final da seleção, resultou em 10 artigos para a elaboração deste trabalho. Resultados: As publicações dos estudos com derivados sintéticos foram identificadas entre os anos de 2014 a 2021. Sendo que a maioria das pesquisas utilizavam a riparina A, seguida pela B, e todos tratavam-se de estudos pré-clínicos. Foram relatados importantes efeitos farmacológicos, como as atividades antibacteriana, antifúngica, anti-inflamatória, antinociceptiva, antitumoral, imunomoduladora, antiprotozoário, antiparasitária, ansiolítica e antioxidante. Discussão: Os estudos realizados com os análogos sintéticos têm colocado as mesmas como possíveis ferramentas terapêuticas, considerando as importantes atividades farmacológicas já relatadas. Conclusão: Contudo, considerando que a literatura já relata seis riparinas sintéticas, o número de artigos publicados voltados para elucidação de possíveis atividades farmacológicas parece reduzido, mesmo sendo promissoras candidatas para o desenvolvimento de pesquisas direcionadas para descobertas de novos fármacos.

show abstract

“…The species Aniba riparia is commonly used for medicinal purposes due to its pharmacological properties, attributed to alkaloids called riparins. Besides the natural molecules of this species, there are synthetic analogues known as riparins A, B, C, D and F, which share structures similar to natural molecules [5] .…”

Section: Introductionmentioning

confidence: 99%

In-silico studies of Riparin B in the design of drugs: Physicochemical, pharmacokinetic and pharmacodynamic parameters

Rodrigues¹,

Oliveira²,

Costa

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

27The process involved in the research, discovery and development of drugs is 28 characterized by high extensive and complex cost linked to scientific and 29 technological innovations, and it is necessary to study and verify the progress of 30 research carried out in the field that results in patent applications. Aniba riparia 31 (Nees) Mez is a plant species often used for therapeutic purposes, where its 32 pharmacological properties are associated to the presence of alkaloids called 33 riparins. 5 synthetic analog compounds (riparins A, B, C, D, E and F) were 34 developed from natural riparins. These molecules, natural and synthetic, showed 35 several pharmacological activities in tests performed in vitro and in vivo, 36 highlighting the Central Nervous System (CNS). The objective of this work was 37 to evaluate the physical-chemical, pharmacokinetic parameters (absorption, 38 distribution, metabolism, excretion and toxicity) and pharmacodynamic 39 parameters (bioactivity and adverse reactions) of Riparin B by means of in silico 40 computational prediction. Online software such as Pre-ADMET, SwissADME, 41 Molinspiration and PASS on line were used for the analysis. Riparin B fits the 42 characteristics of druglikeness, pharmacokinetic properties appropriate to the 43 predicted patterns and activities within the scope for the treatment of AD, 44 demonstrating a possible potential in the inhibition of AChE. Therefore, in silico 45 results allow us to conclude that riparin B is predicted to be a potential future drug 46 candidate, especially via oral administration, due to its relevant Drug-likeness 47 profile, bioavailability, excellent liposolubility and adequate pharmacokinetics,48including at the level of CNS, penetrating the blood-brain barrier. 49 50 73the natural molecules of this species, there are synthetic analogues known as 74 riparins A, B, C, D and F, which share structures similar to natural molecules [5] . 75 4 Synthetic riparin analogues have already demonstrated antioxidant, 76including analysis of isolated mitochondria of the brain of mice [6,7] , antimicrobial [8] , 77 antiparasitic [9] , as well as leishmanicide [10] , vasodilator [7] and anti-inflammatory [11] 78 activities. Among the properties of synthetic riparins, their action in the Central 79Nervous System (CNS), such anxiolytic effects [12] in anxiety models, without 80 affecting the locomotion of the animals used in the experiment [7] , which make 81 them target molecules of new studies aimed at obtaining therapeutic alternatives, 82 and can be used in the treatment of AD. 83However, there is a significant problem that still remains in the drug 84 discovery procedure, particularly in the later stages of conducting research: the 85 analysis of the properties of ADME (absorption, distribution, metabolism and 86 excretion) and the evident toxicity of drug candidates. Over 50% of drug 87 candidates fail due to poor analysis of ADME/Tox during a drug design [2] . 88 To evaluate the physicochemical, pharmacokinetic (absorption,...

show abstract

In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae)

Cited by 19 publications

References 31 publications

In Vitro and Ex Vivo Chemopreventive Action of Mauritia flexuosa Products

In Vitro and Ex Vivo Chemopreventive Action of Mauritia flexuosa Products

Potencial bioativo dos análogos sintéticos das riparinas: uma revisão sistemática

In-silico studies of Riparin B in the design of drugs: Physicochemical, pharmacokinetic and pharmacodynamic parameters

Contact Info

Product

Resources

About