2020
DOI: 10.1007/s00213-020-05600-1
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Antidepressant-like effect of a selenopropargylic benzamide in mice: involvement of the serotonergic system

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Cited by 16 publications
(18 citation statements)
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“…From these results, it can be inferred that the antidepressant-like effect of SeI can involve 5-HT 2A/C receptors. Our findings corroborate previous studies, which have associated the 5-HT 2A/C receptors with the antidepressant-like activity of other organoselenium compounds in mice. 5-HT 2 receptors are highly expressed in many regions of the brain related to humor regulation, suggesting that the mood disorders could be regulated by their activation . The 5-HT 2C subtype receptor agonists present activity in the FST, with an antidepressant-like effect in mice, and genetic ablation of 5-HT 2A receptors potentiated the depressive-like effect of chronic corticosterone administration .…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…From these results, it can be inferred that the antidepressant-like effect of SeI can involve 5-HT 2A/C receptors. Our findings corroborate previous studies, which have associated the 5-HT 2A/C receptors with the antidepressant-like activity of other organoselenium compounds in mice. 5-HT 2 receptors are highly expressed in many regions of the brain related to humor regulation, suggesting that the mood disorders could be regulated by their activation . The 5-HT 2C subtype receptor agonists present activity in the FST, with an antidepressant-like effect in mice, and genetic ablation of 5-HT 2A receptors potentiated the depressive-like effect of chronic corticosterone administration .…”
Section: Resultsmentioning
confidence: 99%
“…This time was set so that the OFT was performed almost at the same time (26 min) after the pre-administration of SeI compared to the other tests (FST and TST). The 30 min pretreatment with SeI was based on previous studies with organoselenium compounds. , …”
Section: Methodsmentioning
confidence: 99%
“…Several studies suggest that the antidepressant-like action of selenium-based compounds can be mediated by serotonergic modulation. ,, SSRIs are most widely prescribed in the previous years to treat patients with depression and anxiety and exert their therapeutic action by regulating 5-HT levels and facilitating their neurotransmission . Thus, experiments were designed to investigate the contribution of different 5-HT receptors in the antidepressant-like action of SeBZF 3 in the TST, and their results can be seen in Figure .…”
Section: Resultsmentioning
confidence: 99%
“…43 In our study, the 5-HT 3 antagonist ondansetron hampered the anti-immobility effects of SeBZF3 in the TST, suggesting its involvement in its antidepressant-like properties. Interestingly, Besckow et al 25 suggested the effects of another organoselenium on 5-HT 3 receptors. However, this receptor has not been suggested to be implicated in the antidepressant-like action of SeBZF1.…”
Section: Involvement Of 5-ht 1a 5-ht 2a/2c and 5-htmentioning
confidence: 99%
“…Sel exerts neuroprotective effects by homeostasis regulations through several mechanisms such as alleviation of oxidative stress (Cosín-Tomàs 2019), in ammatory pathways regulation (Ataizi et al 2019) decrease in DNA destruction (Kryukov et al 2003), increasing telomere length and activity (Cao et al 2017), and modulation of numerous neurotransmitter (Yan et al 2019). Moreover, Sel intricates in the physiopathology of various psychiatric illnesses (Nogueira et al 2011) by modulating serotonergic systems (Besckow et al 2020).…”
Section: Introductionmentioning
confidence: 99%