2023
DOI: 10.1021/acschemneuro.2c00816
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Antidepressant Potential of a Functionalized 3-Selanyl Benzo[b]Furan Compound in Mice: Focus on the Serotonergic System

Abstract: The present study investigated the antidepressant-like potential of a functionalized 3-selanyl benzo­[b]­furan (SeBZF) in male Swiss mice. To evaluate possible antidepressant-like actions, the compounds SeBZF1–5 (50 mg/kg, intragastric, i.g., route) were acutely screened in the tail suspension tests (TSTs). The compound 3-((4-methoxyphenyl)­selanyl)-2-phenylbenzofuran (SeBZF3) was then selected. Dose–response and time–response curves revealed that SeBFZ3 exerts antidepressant-like effects in the TST (5–50 mg/k… Show more

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Cited by 4 publications
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References 46 publications
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