Antibody responses after repeated influenza A virus immunizations among schoolchildren in Japan

Yamane, Nobuhisa; Hiratsuka, Mieko; Arikawa, Jiro; Odagiri, Takato; Ishida, Nakao

doi:10.1017/s002217240006962x

Cited by 5 publications

(8 citation statements)

References 21 publications

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“…The gmt of NAI antibody levels peaked earlier than that of HI antibodies, and decreased in the same manner as HI antibodies. HI antibodies against A/New Jersey/8/76 (HswiNi) were observed only in those vaccinees who received the whole inactivated vaccination of A/New Jersey/8/76 (HswiNi) In a previous publication, we concluded that the present split-vaccine of influenza virus induces a limited spectrum of HI antibody reactivity against heterologous variants, especially in persons who have not experienced natural exposure to the virus, and that it is very difficult to achieve good immunity against NA antigen (Yamane et al 1981). Since then, our main efforts have been focused upon obtaining sufficient levels of immunity against influenza virus in unprimed individuals.…”

Section: Resultsmentioning

confidence: 91%

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Serological evaluation of an influenza A virus cold-adapted reassortant live vaccine, CR-37 (H1N1), in Japanese adult volunteers

Yamane

Nakamura

Yuki

et al. 1984

J. Hyg.

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SUMMARYA cold-adapted influenza A virus, CR-37 (HINI), derived from genetic reassortment between A/Ann Arbor/6/60 (H2N2) cold-adapted variant virus and A/California/10/78 (HINI) wild-type virus, was tested in Japanese adult volunteers. The CR-37 live virus preparation induced only low-grade clinical reactions in volunteers for the first 3-4 days after inoculation. Two vaccinees who did not show any antibody changes became febrile (over 38-0 TC). Skin tests using the vaccine preparation and uninfected allantoic fluid were performed, and indicated that one of these two vaccinees was positive for the CR-37 vaccine preparation. A high proportion of the vaccinees whose sera had a haemagglutination-inhibition (HI) antibody titre against the vaccine strain of < 64 before inoculation, seroconverted in both HI and neuraminidase-inhibition (NAI) antibody titrations, and only a few seroconverted in the titration of antibody against type-specific internal antigens. The serological examinations against heterotypic HINI variants indicated that the cold-adapted live influenza virus vaccine could induce a broad spectrum of HI antibody reactivity and immunity of long duration.

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Section: Resultsmentioning

confidence: 91%

“…(Palmer et al 1975;Yamane et al 1981). For the titration of antibody against the type-specific soluble ('s') antigens of influenza A and B viruses, the single-radial-complementfixation (SRCF) test was employed.…”

Section: Clinical Studymentioning

confidence: 99%

Serological evaluation of an influenza A virus cold-adapted reassortant live vaccine, CR-37 (H1N1), in Japanese adult volunteers

Yamane

Nakamura

Yuki

et al. 1984

J. Hyg.

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“…The geometric mean titres of HI antibodies and the geometric mean concentrations of IgE and IgG antibodies were calculated with log transformation, and Student's paired t test was performed as previously described (Yamane et al 1981).…”

Section: Discussionmentioning

confidence: 99%

“…(1) The standard haemagglutination-inhibition (HI) test was performed using the vaccine strains, A/Bangkok/10/83(H1N1), A/Philippines/2/82(H3N2) and B/USSR/100/83, as previously described (Yamane et al 1981).…”

Section: Serological Testsmentioning

confidence: 99%

Serological examination of IgE- and IgG-specific antibodies to egg protein during influenza virus immunization

Yamane

Uemura

1988

Epidemiol. Infect.

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SUMMARYThe concentrations of serum IgE (PRIST) and IgE-and IgG-specific antibodies to egg protein were determined in paired sera taken from students who had received influenza virus vaccine. Although persons who gave a history of allergy to egg or to chicken feathers were excluded, 10-16 % of vaccinees possessed higher titres of serum IgE and IgE-specific antibody (RAST) to egg white (Fl) allergen before vaccination. The titres of IgG-specific antibody to egg protein (ovalbumin and ovomucoid antigens) were negligible, and did not show any significant response after vaccination. In contrast, IgE-specific antibody to F1 allergen rose significantly in a considerable number of the vaccinees. The results obtained indicate possible contamination of vaccine products with allergens of egg origin and a potential risk of allergic manifestation after influenza vaccination.

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“…At present in Japan, split vaccine of influenza virus is given annually to school children from kindergarten to senior high school age (1). Antibodies against both HA and NA antigens, but not against internal antigen, nucleoprotein (NP), have been reported to rise after split influenza virus vaccination (15). While it is necessary to titrate antibody levels against s antigen to distinguish natural infection from vaccine response, the standard CF test remains less popular for serodiagnosis than the HI test because it is somewhat more complex and time consuming.…”

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confidence: 99%

Single radial complement fixation test for assaying antibody to influenza virus type-specific antigens

Yamane¹,

Yuki²,

Nakamura³

1983

J Clin Microbiol

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An immunodiffusion technique in agarose is described for assay of complementfixing antibodies against the type-specific soluble antigen of influenza virus. Under the test conditions, positive human serum produced a definite unlysed zone around the well, and the annulus area showed a high correlation with the antibody level in a conventional complement fixation test with log2 serum titer. This paper also describes the use of this method as a diagnostic procedure for the assay of antibodies against soluble antigens of influenza A and B viruses in paired human sera collected from persons infected with the virus or who received ether-split vaccine. This method appears to be more sensitive and gives more consistent results for serodiagnosis of infection cases than do the hemagglutination inhibition, neuraminidase inhibition, and complement fixation tests. Our results suggest that the single radial complement fixation test can provide a simple and reliable method for serodiagnosis of influenza virus infection.

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Antibody responses after repeated influenza A virus immunizations among schoolchildren in Japan

Cited by 5 publications

References 21 publications

Serological evaluation of an influenza A virus cold-adapted reassortant live vaccine, CR-37 (H1N1), in Japanese adult volunteers

Serological evaluation of an influenza A virus cold-adapted reassortant live vaccine, CR-37 (H1N1), in Japanese adult volunteers

Serological examination of IgE- and IgG-specific antibodies to egg protein during influenza virus immunization

Single radial complement fixation test for assaying antibody to influenza virus type-specific antigens

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