SUMMARYAntibody responses to influenza virus immunizations were examined among junior high school students. The students received two doses of a commercial split-product vaccine containing influenza A HINI during a 2-year period following the first appearance of HINI virus in the winter of 1977-78. In haemagglutination-inhibition (HI) tests, the students who had been infected with HiNt virus in 1977-78 showed a better response and wider cross-reactivity to the drift strain than the students who had not experienced earlier HiN1 influenza infection. Neuraminidase-inhibition (NAI) antibody titres after immunization depended upon a history of natural infection with HINt virus, since students not previously infected showed no significant NAI antibody rise after immunization.
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