Antibacterial high-genus polymer vesicle as an “armed” drug carrier

Zhu, Hongshi; Geng, Qingrui; Chen, Wenqin; Zhu, Yunqing; Chen, Jing; Du, Jianzhong

doi:10.1039/c3tb20713g

Cited by 43 publications

(60 citation statements)

References 39 publications

(51 reference statements)

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“…In addition, these hollow structures are potentially promising as delivery vehicles for nano medicines. The same diblock copolymer was self-assembled into an ''armed'' high-genus vesicle by a solvent switch method [175]. These high-genus vesicles were even better at antimicrobial activities and excellent in hemocompatibility.…”

Section: Antimicrobial Polymer Assembliesmentioning

confidence: 99%

Controlling macromolecular structures towards effective antimicrobial polymers

Ganewatta

Tang

2015

Polymer

210

255

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Section: Antimicrobial Polymer Assembliesmentioning

confidence: 99%

Controlling macromolecular structures towards effective antimicrobial polymers

Ganewatta

Tang

2015

Polymer

210

255

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“…Polymer vesicles (also known as polymersomes) are composed of amphiphilic diblock copolymers, which self‐assemble into bilayer structures, typically in aqueous solution, with various shapes and sizes . In literature, the applications of polymer vesicles have been extended in the biomedical field for drug/gene delivery, magnetic resonance imaging (MRI), cell mimicking and theranostics platforms . A variety of antibacterial agents, such as silver nanoparticles (AgNPs), superparamagnetic iron oxide nanoparticles, and antibiotics, can be readily loaded into the polymer vesicles for the treatment of bacterial infection .…”

Section: Biodegradable Polymeric Nanosystems Containing Antibioticsmentioning

confidence: 99%

Biodegradable Antibacterial Polymeric Nanosystems: A New Hope to Cope with Multidrug‐Resistant Bacteria

Ding

Wang

Tong

2019

Small

145

108

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Figure 17. a) Schematic illustration for the fabrication of chlorhexidine diacetate (CHX)-loaded antibacterial nanogels for hemostasis and wound healing applications. b) Wound healing processes after treated with different materials. Reproduced with permission. [109] Figure 25. a) Schematic illustration, b) synthetic route, and c) TEM images of phosphonium-functionalized polymer micelles. Reproduced with permission. [126]

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“…The antibacterial properties of polymer vesicles were obtained by two methods [27] . First, all the wells of 96 well plates were filled with the LB Agar culture solution (100 μL), then each cells of the first line was injected with vesicles solution (~10.0 mg/mL, 100 μL).…”

Section: Antibacterial Testmentioning

confidence: 99%

Preparation of water dispersible poly(methyl methacrylate)-based vesicles for facile persistent antibacterial applications

Wang

Yuan

2015

Chin J Polym Sci

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We report a facile strategy for incorporating persistent and effective antibacterial property into a widely used polymer, poly(methyl methacrylate) (PMMA), by copolymerizing methyl methacrylate (MMA) with 2-(tert-butylamino)ethyl methacrylate (TA) in one pot via atom transfer radical polymerization (ATRP). The subsequent self-assembly of the resultant poly(methyl methacrylate)-block-poly[(2-tert-butylamino)ethyl methacrylate] (PMMA 20 -b-PTA 15 ) diblock copolymer affords well-defined water-dispersible vesicles, which can be facilely sprayed on the walls in hospitals for effective inhibition and killing of bacteria. 1 H-NMR and gel permeation chromatography (GPC) studies confirmed the successful synthesis of welldefined copolymer. Transmission electron microscopy (TEM), atomic force microscopy (AFM) and dynamic light scattering (DLS) studies proved the formation of vesicles with narrow size distribution. DLS studies revealed the excellent stability of vesicles at various temperatures. Antibacterial tests showed effective antibacterial activities of polymer vesicles against both Gram-positive and Gram-negative bacteria. Moreover, this strategy may be extended for preparing a wide range of polymeric materials for facile antibacterial applications in many fields.

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Antibacterial high-genus polymer vesicle as an “armed” drug carrier

Cited by 43 publications

References 39 publications

Controlling macromolecular structures towards effective antimicrobial polymers

Controlling macromolecular structures towards effective antimicrobial polymers

Biodegradable Antibacterial Polymeric Nanosystems: A New Hope to Cope with Multidrug‐Resistant Bacteria

Preparation of water dispersible poly(methyl methacrylate)-based vesicles for facile persistent antibacterial applications

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