Preparation of water dispersible poly(methyl methacrylate)-based vesicles for facile persistent antibacterial applications

Abstract

We report a facile strategy for incorporating persistent and effective antibacterial property into a widely used polymer, poly(methyl methacrylate) (PMMA), by copolymerizing methyl methacrylate (MMA) with 2-(tert-butylamino)ethyl methacrylate (TA) in one pot via atom transfer radical polymerization (ATRP). The subsequent self-assembly of the resultant poly(methyl methacrylate)-block-poly[(2-tert-butylamino)ethyl methacrylate] (PMMA 20 -b-PTA 15 ) diblock copolymer affords well-defined water-dispersible vesicles, which can be facilely sprayed on the walls in hospitals for effective inhibition and killing of bacteria. 1 H-NMR and gel permeation chromatography (GPC) studies confirmed the successful synthesis of welldefined copolymer. Transmission electron microscopy (TEM), atomic force microscopy (AFM) and dynamic light scattering (DLS) studies proved the formation of vesicles with narrow size distribution. DLS studies revealed the excellent stability of vesicles at various temperatures. Antibacterial tests showed effective antibacterial activities of polymer vesicles against both Gram-positive and Gram-negative bacteria. Moreover, this strategy may be extended for preparing a wide range of polymeric materials for facile antibacterial applications in many fields.

Efficient Removal of Polycyclic Aromatic Hydrocarbons, Dyes, and Heavy Metal Ions by a Homopolymer Vesicle

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Polymersome Wound Dressing Spray Capable of Bacterial Inhibition and H2S Generation for Complete Diabetic Wound Healing

“…AMP-embedded polymersomes can stick to the bacterial surface by locally amplifying the positive charge density on the surface of polymersomes, leading to bacterial death. Therefore, this strategy affords a much higher bacterial inhibition effect compared to molecularly dissolved AMPs. , Additionally, polymersomes have the ability to stick to the membrane of bacteria via electrostatic interactions; subsequently, these nanoparticles can penetrate and kill the bacteria. , Indeed, such individual polymersomes utilize a similar mechanism to that of natural antimicrobial peptides …”

Synthesis and Mechanism Insight of a Peptide-Grafted Hyperbranched Polymer Nanosheet with Weak Positive Charges but Excellent Intrinsically Antibacterial Efficacy

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