The
design and use of materials in the nanoscale size range for addressing
medical and health-related issues continues to receive increasing
interest. Research in nanomedicine spans a multitude of areas, including
drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable
devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these
developments are starting to be translated into viable clinical products.
Here, we provide an overview of recent developments in nanomedicine
and highlight the current challenges and upcoming opportunities for
the field and translation to the clinic.
Highly biocompatible pH-sensitive diblock copolymer vesicles were prepared from the self-assembly of a biocompatible zwitterionic copolymer, poly[2-(methacryloyloxy)ethyl phosphorylcholine-block-2-(diisopropylamino)ethyl methacrylate], PMPC-b-PDPA. Vesicle formation occurred spontaneously by adjusting the solution pH from pH 2 to above 6, with the hydrophobic PDPA chains forming the vesicle walls. Transmission electron microscopy (TEM), dynamic laser light scattering (DLS), and UV-visible absorption spectrophotometry were used to characterize these vesicles. Gold nanoparticle-decorated vesicles were also obtained by treating the vesicles with HAuCl4, followed by NaBH4.
Polymer vesicles prepared by self-assembly techniques have attracted increasing scientific interest in recent years. This is as a result of their numerous potential applications such as tunable delivery vehicles, for the templating of biomineralization, as nanoreactors and as scaffolds for biological conjugation. Presented in this review are the recent advances in the preparation and application of 'smart' and functional block copolymer vesicles such as those which respond to external stimuli to afford a change in structure, morphology or controlled release event. In this Highlight, we first give an overview of the structure of polymer vesicles, followed by a summary of the methods used for their preparation. We then focus on recently developed intelligent polymer vesicles which can respond to the application of external stimuli such as a change in temperature, pH or redox to afford novel nanomaterials. The potential applications of these materials are explored with specific focus on the functionalization of various domains of the polymer vesicles. Finally, the current limitations in the preparation and application of polymer vesicles are explored as are the challenges facing the development of these nanostructures towards real-world applications.
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