Biodegradable Antibacterial Polymeric Nanosystems: A New Hope to Cope with Multidrug‐Resistant Bacteria

Abstract

Figure 17. a) Schematic illustration for the fabrication of chlorhexidine diacetate (CHX)-loaded antibacterial nanogels for hemostasis and wound healing applications. b) Wound healing processes after treated with different materials. Reproduced with permission. [109] Figure 25. a) Schematic illustration, b) synthetic route, and c) TEM images of phosphonium-functionalized polymer micelles. Reproduced with permission. [126]

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

“…Common polymeric backbones used for constructing micellar systems include chitosan, polyethylene oxide, polypropylene oxide, polybutylene oxide, polystyrene oxide, polyethyleneimine, and polycaprolactone. The size of polymeric micelles is from almost 10 to 100 nm [109].…”

A novel nanoparticle loaded with methyl caffeate and caffeic acid phenethyl ester against Ralstonia solanacearum—a plant pathogenic bacteria

“…11 Furthermore, polymeric nanoparticles have been considered to be the most promising approach against drug resistance of bacteria. 12,13 Nanoparticles can be used as alternative tools to handle drug-resistant pathogens. 14 Hence, nanoparticles prepared with PLGA have the potential to be an alternative to traditional pesticides.…”

Recent Advances and Future Prospects on Adaptive Biomaterials for Antimicrobial Applications

“…Adaptive biomaterials are materials that can adjust their physiochemical properties according to variations in the surrounding microenvironment and adapt themselves to the surrounding microenvironment to potentiate their biological functions. Adaptive biomaterials possess two main strategies to overcome bacterial resistance development . With rational design, adaptive materials are able to eradicate bacteria in a “contact and kill” manner, which is also efficient to eradicate the multidrug‐resistant bacteria .…”

“…Adaptive biomaterials possess two main strategies to overcome bacterial resistance development. [21,22] With rational design, adaptive materials are able to eradicate bacteria in a "contact and kill" manner, which is also efficient to eradicate the multidrug-resistant bacteria. [23] Moreover, adaptive nanocarriers can deliver antimicrobials to overcome the barriers of biofilms and cells, enhance the efficacy of conventional antimicrobial, and reduce their dose of antimicrobials as well as the likelihood of pathogens being resistant to antimicrobials.…”