ANTIBACTERIAL EFFECTIVITY OF KASTURI LEAF EXTRACT (Mangifera casturi) AGAINST THE GROWTH OF Streptococcus sanguinis BACTERIA

Abstract

Background: Caries is a disease that occurs because of the fermentation carbohydrates process by microorganisms in the oral cavity. One of the bacteria that causes caries is Streptococcus sanguinis. These bacteria will colonize on the tooth surface, then form dental plaques and contribute to the causes of caries and other periodontal diseases. Kasturi leaf extract (Mangifera casturi) has various compounds such as tannins, terpenoids, alkaloids, and flavonoids that have antimicrobial substances. Purpose: The aim of this study was to determine antibacterial effectivity of kasturi leaf extract (Mangifera casturi) against the growth of Streptococcus sanguinis bacteria. Method: This research was an experimental method laboratory (true experimental), with a randomized pre test and post test with control group design using 5 treatments: kasturi leaf extract (concentration: 20 mg/ml, 25 mg/ml, and 30 mg/ml); and two groups of control: positive control and negative control. Each treatment was repeated 5 times. Antibacterial activity testing used a liquid dilution method. Measurement of minimum inhibitory concentration (MIC) used a Uv-Vis Spectrophotometer and measurement of the minimum bactericidal concentration (MBC) used a colony counter. The MIC data were analyzed using One Way Anova and continued with the Dunnet Post Hoc test. MBC data were analyzed using the Kruskal-Wallis test and continued with the Mann-Whitney Post Hoc test. Result: One-Way Anova test showed that MIC had a significant difference, and the Kruskal-Wallis test showed that MBC also had significant differences. MIC was obtained at the concentration of 20 mg/ml and MBC was obtained at the concentration of 30 mg / ml. Conclusion: There is antibacterial effectiveness in kasturi leaf extract (Mangifera casturi) against the growth of Streptococcus sanguinis.

PENGARUH EKSTRAK DAUN KASTURI TERHADAP KADAR LIMFOSIT MENCIT JANTAN (Mus musculus) YANG DIPAPAR SINAR-X RADIOGRAFI PERIAPIKAL

“…6 Kasturi (Mangifera casturi) merupakan tanaman khas Kalimantan Selatan yang memiliki banyak manfaat. 7 Daun kasturi mengandung bahan bioaktif, seperti alkaloid, flavonoid, tanin, terpenoid, fenol, dan saponin yang dapat berperan sebagai antioksidan, antibakteri, antiinflamasi, dan imunostimulator. 8,9,10…”

PENGARUH EKSTRAK DAUN KASTURI TERHADAP KADAR TROMBOSIT MENCIT JANTAN (Mus musculus) YANG DIPAPAR SINAR-X RADIOGRAFI PERIAPIKAL

“…9 Antioksidan dipercaya dapat menangkal radikal bebas yang reaktif, salah satu tumbuhan yang dapat digunakan adalah daun kasturi. 10,11 Daun kasturi (Mangifera casturi) adalah tumbuhan khas Kalimantan Selatan yang memiliki kandungan antioksidan golongan sangat kuat dengan nilai IC50 sebesar 34,558 ppm. 11,12 Daun kasturi mengandung senyawa aktif seperti, flavonoid, fenol, alkaloid, tanin, terpenoid, dan saponin yang dapat berperan sebagai antioksidan, antibakteri, antiinflamasi, dan imunomodulator.…”

“…10,11 Daun kasturi (Mangifera casturi) adalah tumbuhan khas Kalimantan Selatan yang memiliki kandungan antioksidan golongan sangat kuat dengan nilai IC50 sebesar 34,558 ppm. 11,12 Daun kasturi mengandung senyawa aktif seperti, flavonoid, fenol, alkaloid, tanin, terpenoid, dan saponin yang dapat berperan sebagai antioksidan, antibakteri, antiinflamasi, dan imunomodulator. Senyawa flavonoid dan fenolat memiliki aktivitas antioksidan dengan mereduksi, menangkap radikal bebas juga sebagai pendonor elektron.…”

ANTIBACTERIAL ACTIVITY OF RAMANIA LEAF EXTRACT (Bouea Macrophylla Griff) AGAINST THE GROWTH Actinomyces spp

“…Treatment that can be done to treat pulp necrosis is root canal treatment. 3,4 Root canal treatment is carried out to remove microorganisms present in the root canals of teeth or substantially reduce the work of microbes. 3 Irrigation is one of the important factors in achieving the success of root canal treatment.…”