Antibacterial effect and mechanism of silver-carried zirconium glycine-N,N-dimethylenephosphonate as a synergistic antibacterial agent

Liu, Changhua; Luo, Liehong; Liu, Li

doi:10.1016/j.inoche.2019.107497

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…First, the silver nanoparticles disrupt the cell wall and cell membranes of microorganisms by attaching to the negatively charged cell surface. This damages their important functions, such as electron transport, permeability, respiration, and osmoregulation . Second, silver nanoparticles damage the cell wall of bacteria by penetrating the cell and interacting with proteins, DNA, and other sulfur- and phosphorus-containing cell components.…”

Section: Resultsmentioning

confidence: 99%

“…This damages their important functions, such as electron transport, permeability, respiration, and osmoregulation. 58 Second, silver nanoparticles damage the cell wall of bacteria by penetrating the cell and interacting with proteins, DNA, and other sulfur- and phosphorus-containing cell components. Third, the silver nanoparticles in the microorganism release silver ions, which have a biocidal effect that depends on their size and dosage.…”

Section: Resultsmentioning

confidence: 99%

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Green Synthesis and Characterization of Biologically Synthesized and Antibiotic-Conjugated Silver Nanoparticles followed by Post-Synthesis Assessment for Antibacterial and Antioxidant Applications

U Din,

Batool,

Ashraf

et al. 2024

ACS Omega

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The paper presents the antibacterial and antioxidant activities of silver nanoparticles (AgNPs) when conjugated with two antibiotics levofloxacin and ciprofloxacin as well as biologically synthesized nanoparticles from Moringa oleifera and Curcuma longa. Leaves of Moringa and powder of Curcuma were used in the green synthesis of silver nanoparticles. Ultraviolet−visible spectroscopy (UV), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) were used for the characterization of the synthesized silver nanoparticles. Comparison of levofloxacin and ciprofloxacin and their conjugated AgNPs was also studied for antibacterial and antioxidant activity. The synthesis of Moringa-AgNPs, turmeric-AgNPs, levofloxacin-AgNPs, and ciprofloxacin-AgNPs was confirmed by UV spectroscopy. An absorption peak value of 400−450 nm was observed, and light to dark brown color indicated the synthesis of AgNPs. Moringa-AgNPs revealed high antioxidant activity (80.3 ± 3.14) among all of the synthesized AgNPs. Lev-AgNPs displayed the highest zone of inhibition for Staphylococcus aureus, while in Escherichia coli, Cip-AgNPs showed high antibacterial activity. Furthermore, AgNPs synthesized using green methods exhibit high and efficient antimicrobial activities against two food-borne pathogens. Biologically synthesized nanoparticles exhibited antibacterial activity against E. coli (13.73 ± 0.46 with Tur-AgNPs and 13.53 ± 0.32 with Mor-AgNPs) and S. aureus (14.16 ± 0.24 with Tur-AgNPs and 13.36 ± 0.77 with Mor-AgNPs) by using a well diffusion method with significant shrinkage and damage of the bacterial cell wall, whereas antibiotic-conjugated nanoparticles showed high antibacterial activity compared to biologically synthesized nanoparticles with 14.4 ± 0.37 for Cip-AgNPs and 13.93 ± 0.2 for Lev-AgNPs for E. coli and 13.3 ± 0.43 for Cip-AgNPs and 14.33 ± 0.12 for Lev-AgNPs for S. aureus. The enhanced efficiency of conjugated silver nanoparticles is attributed to their increased surface area compared to larger particles. Conjugation of different functional groups contributes to improved reactivity, creating active sites for catalytic reactions. Additionally, the precise control over the size and shape of greensynthesized nanoparticles further augments their catalytic and antibiotic activities.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%