Antibacterial and Antioxidant Activity of Black Mulberry (Morus nigra L.) Extract for Acne Treatment

Budiman, Arif; Aulifa, Diah Lia; Kusuma, Arif Satria Wira; Sulastri, Astri

doi:10.5530/pj.2017.5.97

Cited by 27 publications

(21 citation statements)

References 13 publications

(14 reference statements)

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“…2,3 Some of the bacteria that cause acne include P. acnes, S. epidermidis, and S. aureus. 4,5 In Indonesia, around 95-100% of young men and 83-85% of young women suffering from acne. The prevalence of acne in adult women is around 12% and 3% in adult men.…”

Section: Introductionmentioning

confidence: 99%

“…In another study, it was found that acne is a skin problem until past adolescence with a higher prevalence of women than men in the age range of 20 years or more. 5,6 Giving antibiotics is one alternative acne treatment that aims to reduce the bacterial population. However, giving antibiotics to acne patients was reported to increase the occurrence of upper respiratory tract infections when compared with acne patients without antibiotic therapy.…”

Section: Introductionmentioning

confidence: 99%

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Potential Anti-acne: Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) from Central Kalimantan-Indonesia

Novaryatiin¹,

Ardhany²

2020

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Background: Research development has been carried out by exploring antimicrobial agents from herbal sources that can be further developed as anti-acne drugs. Some previous studies reported that bawang dayak has antibacterial properties. However, the study of bawang dayak as anti-acne in Indonesia was limited so that it becomes one of the reasons why this study should be developed. Objective: This study was aimed to determine the minimum inhibitory concentration (MIC) of bawang dayak ethanol extract and to determine the antibacterial activity of the chloroform fraction and the ethyl acetate fraction of bawang dayak extract. Methods: The MIC value was determinate by measured initial absorbance and final absorbance of ten variations of concentration of extract using a UV-Vis spectrophotometer. The antibacterial activity of chloroform and ethyl acetate fraction was performed using the disc diffusion technique, with five variations of concentration against P.acnes, S. epidermidis, S. aureus. Results: The decrease in absorbance value occurred at a concentration of 0.19%, 1.56% to 100%, which means that at that concentration can inhibit bacterial growth. The antibacterial activity showed that both the chloroform fraction and ethyl acetate fraction of bawang dayak extract were active against all the tested bacteria, whose inhibition zones were in the range of 5.8 ± 0.9 -23.6 ± 2.3 mm. However, the ethyl acetate fraction of bawang dayak extract showed better antibacterial activity than chloroform fraction of bawang dayak extract. Conclusion: In this study, it was found that the concentration of 0.19% is the MIC of bawang dayak extract against P. acnes. The highest antibacterial activity was produced by 20% of ethyl acetate fraction of bawang dayak extract against S. aureus.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential Anti-acne: Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) from Central Kalimantan-Indonesia

Novaryatiin¹,

Ardhany²

2020

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“…10 DPPH assay is most suitable for polar compounds because the DPPH crystals can dissolve easily in a commonly solvent and give maximum absorbance. 28 Based on Figure 2, E2 and E3 shows greater % scavenging effect, compared to E1. TPC of T. hempricii related with the antioxidant activity.…”

Section: Discussionmentioning

confidence: 89%

In-vitro Evaluation of Antioxidant Activity and Anti-collagenase Activity of Thalassia hempricii as a Potent Ingredients for Anti-Wrinkle Cosmetics

Zakiah

Anwar²,

Nurhayati

2018

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Background:Thalassia hemprichii have reported containing antioxidant effects. However, information on other biological activities relating to the anti-wrinkle properties is limited. The free radical scavenging activity and enzyme inhibitory activity of the plant extracts investigated that they can help restore skin elasticity and thereby slow the wrinkling process. Objective: To evaluate in-vitro antioxidant and anti-collagenase activity of T. hemprichii as a potent ingredient for anti-wrinkle cosmetic. Methods: T. hemprichii was extracted with ethanol 100% (E1) 75% (E2) and ethanol 50% (E3) using maceration extraction method for 24 h, thrice. The extract was examined for total phenolic content, antioxidant activity compared with vitamin C, and the best extract was tested for the inhibitory activity of collagenase. Results: The total phenolic content of T. hempricii extract was 0,525 ± 0,016 mg GAE/100 g extract (E1) 0,538 ± 0,006 mg GAE/100 g extract (E2) and 0,558 ± 0,090 mg GAE/100 g extract (E3) respectively. The antioxidant activity (% inhibition) of the extract was 38,035 ± 0,252 % (E1), 52,502 ± 6,225 % (E2) and 57,261 ± 0,505 % (E3). Ascorbic acid as a positive control of antioxidant activity showed much higher % inhibition than the sample with 78,055 ± 0,756 %. As the best extract from antioxidant activity, E2 and E3 have inhibited collagenase activity with 51,809 ± 0,164 % and 52,212 ± 0,735 % at 20μg/mL respectively. Conclusion: In general the (T. hempricii) extract can be used as a potential active ingradient for anti-wrinkles cosmetic.

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“…The phenol content of black mulberry fruit can provide pharmacological activities such as antioxidant 13 , antibacterial 14 , hypolipidemic effect 15 and macrophage activation effect 16 . The highest concentration of phenol can be found in black mulberry fruit (Morus nigra L) 17 , and with this high phenolic content black mulberry has potential for antioxidant activity 1,18 .…”

Section: Chemical Constituents and Pharmacological Activitymentioning

confidence: 99%

Chemical Compounds and Pharmacological Activity of Morus Nigra as a Potential Product of Drug: A Review

Budiman¹,

Sulastri²,

Qoriah³

2018

Int. Res. J. Pharm.

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Black mulberry fruit (Morus nigra L.) is spread over the subtropical regions of the earth and can grow in various topography and climatic conditions. Its fruit mostly proceeds to become juice, jam, coloring agent and a flavoring for ice cream. Traditionally, the leaves and fruit of Morus nigra L. are used to treat dysentery, diabetes mellitus, hypertension, arthritis, and anemia and can also act as a laxative, odontalgia, anthelmintic, expectorant, hypoglycemic and emetic agent. These pharmacological activities might be caused by a high amount of active compounds in black mulberry. Based on the literature studies, there are 56 compounds isolated from various parts of black mulberry, including the root bark, roots, bark, wood, leaves and fruit. The chemical constituents found in black mulberry contribute to its pharmacological properties, such as antihyperglycemic, cytotoxic against leukemia cells, antioxidative, antibacterial, anti-inflammatory and inhibition of tyrosinase.

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Antibacterial and Antioxidant Activity of Black Mulberry (Morus nigra L.) Extract for Acne Treatment

Cited by 27 publications

References 13 publications

Potential Anti-acne: Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) from Central Kalimantan-Indonesia

Potential Anti-acne: Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) from Central Kalimantan-Indonesia

In-vitro Evaluation of Antioxidant Activity and Anti-collagenase Activity of Thalassia hempricii as a Potent Ingredients for Anti-Wrinkle Cosmetics

Chemical Compounds and Pharmacological Activity of Morus Nigra as a Potential Product of Drug: A Review

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