Antibacterial and Antifungal Activities of Jatropha multifida (Ogege) Sap against Some Pathogens

Aransiola, Michael Niyi; Ehikhase, Charles; Mmegwa, Joy C; Wahab, Idris Olayinka

doi:10.9790/3008-09415357

Cited by 8 publications

(8 citation statements)

References 12 publications

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“…Result also showed that the sap extract of Jatropha curcas Linn, showed the highest antimicrobial activity than both Methanol and aqueous extracts of leave and stem bark with the highest diameter of zone of inhibition (21.00 mm) at 1000 µg/mL (Table 4b). This correlates with the observation previously reported by (Aransiola et al, 2014;Abubakar et al, 2016).…”

Section: Resultssupporting

confidence: 93%

“…In their separate studies, (Aransiola et al, 2014;Abubakar et al, 2016) had earlier reported that Jatropha curcas Linn sap have varied antibacterial and antifungal activities against bacteria and Candida species which suggests that, the sap of this plant has broad spectrum of activities. Also (Srinivasan et al, 2001) reported that different solvents have different extraction capacities and different spectrum of solubility for the phyto-constituents.…”

Section: Discussionmentioning

confidence: 99%

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Antifungal Activity of Jatropha Curcas Linn on Candida Albicans and Candida Tropicalis Associated with Neonatal and Infantile Infections in Yola, Nigeria

Doughari¹,

Abraham²

2021

American Journal of Agricultural and Biological Sciences

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One hundred and eighty (180) stool samples collected of neonates and infants from three selected health facilities in Yola, Adamawa State Nigeria. The samples were subjected to both microscopic, biochemical test and cultural identification. Bromocresol green agar and Germ tube test was used to identify Candida species. Culture of the stool samples on SDA yielded 32 yeast cells with Candida albicans as the predominant (90.63%) organism isolated followed by Candida tropicalis (9.37%). Extraction and screening for phytoconstituents of Jatropha curcas Linn parts (stem bark, leave and sap) by hot maceration using water and methanol. Showed the presence of saponins, tannins, phenols, alkanoids, steroids, flavonoids, terpenoids and glycosides. Antifungal susceptibility testing on Mueller Hinton agar, showed yeast to be susceptible to the Methanol plant extract at 400-1000 µg/mL with highest diameters of zones of inhibition (20.00 mm for sap, 13.00 mm for stem bark and 11.00 mm for leave) than the aqueous plant extract. All the parts of Jatropha curcas Linn showed MIC range of 400-1200 µg/mL for both Candida albicans and Candida tropicalis. GC-MS study showed the presence of 11 most abundant components out of 52 compounds of the methanol leaves extract 46 compounds of methanol stem bark extracts respectively all of which demonstrated antimicrobial activity. Result also showed 12 most abundant components out of 56 compounds in sap of Jatropha curcas Linn with antimicrobial activity. Further study on the toxicity and pharmacological activity should be carried out, with a view to sourcing novel antibiotic substances for possible development of broad spectrum drugs against both bacteria and fungi.

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Section: Resultssupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Antifungal Activity of Jatropha Curcas Linn on Candida Albicans and Candida Tropicalis Associated with Neonatal and Infantile Infections in Yola, Nigeria

Doughari¹,

Abraham²

2021

American Journal of Agricultural and Biological Sciences

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“…Tannins are known to have inhibitory activities on the growth of S. aureus and P. aeruginosa [26]. Flavonoids cause lysis of the membrane and consequently death of the cell [18] [27]. These mechanisms of action of tannins and flavonoids could partly explain the bactericidal and bacteriostatic effects given by the aqueous, hydroethanolic and ethanolic extracts of S. aromaticum on the tested microorganisms.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activities of Syzygium aromaticum (L.) Merr. and L.M. Perry (Myrtaceae) Fruit Extracts on Six Standard Microorganisms and Their Clinical Counterpart

Afanyibo¹,

Anani²,

Esseh³

et al. 2018

OALib

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Syzygium aromaticum is used in combination with other plants as an alcoholic infusion by traditional practitioners to treat infections. It has been selected for evaluation for its antimicrobial properties to justify its use in traditional pharmacopoeia. The fruits were used as plant material while the microbial germs consisted of six reference strains: Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Salmonella typhimurium ATCC 14028, Pseudomonas aeruginosa ATCC 27853, Shigella flexneri ATCC 12022, Candida albicans ATCC 35659 and their clinical counterparts. The extracts were obtained by aqueous decoction, hydroethanolic and ethanolic macerations. The phytochemical screening was performed by chemical staining tests. The antibiotic susceptibility test was performed using the well diffusion method and the MIC and MBC or MFC were determined using the 96-well microplate dilution method. The results showed that 66.67% of the strains tested were sensitive to the aqueous extract with inhibition diameters ranging from 15 to 21 mm and MIC and MCB or MFC between 0.0976-0.3906 mg/mL and 0.1953-07812 mg/mL respectively, thus determining bacteriostatic activity. 100% of the germs tested were sensitive to hydroethanolic and ethanolic extracts. The inhibition diameters range from 12-28 mm for hydroethanolic extract with MIC and MBC or MFC ranging from 0.0488-0.3906 mm and 0.0488-0.7812 mm respectively. The ethanolic extract gave inhibition diameters of 12-26 mm; MIC and MBC or MFC ranging from 0.

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“…[ 23 ] The antibacterial activity of flavonoid results in lysis of the membrane, followed by the death of the cell. [ 24 ] The greater resistance of P. aeruginosa strains as those of S. aureus could be due to the difference between their cell wall. Gram-negative bacteria possess a highly hydrophilic outer surface of the membrane, while the lipophilic ends of lipoteichoic acids in the cell membrane of Gram-positive bacteria may facilitate penetration of the hydrophobic compounds.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial, Anti-inflammatory and antioxidant activities of Jatropha multifida L. (Euphorbiaceae)

Anani¹,

Adjrah²,

Ameyapoh³

et al. 2016

Phcog Res

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Background:Jatropha multifida is used in Togolease folk medicine for the healing of chronic wounds.Objective:This study aims to investigate antibacterial, anti-inflammatory and antioxidant activities of the leaves ethanolic extract.Materials and Methods:The antimicrobial activity was assayed by National Committee for Clinical Laboratory Standards broth microdilution method on strains of Staphylococcus aureus and Pseudomoas aeruginosa isolated from wounds, whereas the anti-inflammatory activity was performed by carrageenan and histamine induced paw edema method in rat modele. The 2, 2-diphenyl-1picrylhydrazyl (DPPH) free radical scavenging and ferric reducing antioxidant power (FRAP) were used for the antioxidant activity.Results:The antibacterial assay showed an in vitro growth inhibition of P. aeruginosa and S. aureus in dose-dependent manner, with minimum inhibitory concentration values ranging from 2.5 to 3.12 mg/mL for S. aureus and from 6.25 to 12.5 mg/mL for P. aeruginosa. The maximum paw anti-inflammatory effect occurred after 3 and 5 h administration of histamine and carrageenan, respectively. The DPPH radical scavenging and the FRAP assays yielded weak antioxidant activity.Conclusion:J. multifida possesses antibacterial and anti-inflammatory activities that could justify the use of the plant for the treatment of wounds in the folk medicine.SUMMARY Antibacterial on germs isolated from wound, anti-inflammatory and antioxidant activities of Jatropha multifida were assayed by NCCLS broth method, carrageenan and histamine, DPPH and FRAP respectively. The results indicated that Jatropha multifida possesses antibacterial and anti-inflammatory and weak antioxidant activities that could justify its use for the treatment of wounds in the folk medicine.

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Antibacterial and Antifungal Activities of Jatropha multifida (Ogege) Sap against Some Pathogens

Cited by 8 publications

References 12 publications

Antifungal Activity of Jatropha Curcas Linn on Candida Albicans and Candida Tropicalis Associated with Neonatal and Infantile Infections in Yola, Nigeria

Antifungal Activity of Jatropha Curcas Linn on Candida Albicans and Candida Tropicalis Associated with Neonatal and Infantile Infections in Yola, Nigeria

Antimicrobial Activities of Syzygium aromaticum (L.) Merr. and L.M. Perry (Myrtaceae) Fruit Extracts on Six Standard Microorganisms and Their Clinical Counterpart

Antimicrobial, Anti-inflammatory and antioxidant activities of Jatropha multifida L. (Euphorbiaceae)

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