Antibacterial and anticandidal screening of Tunisian Citrullus colocynthis Schrad. from Medenine

Marzouk, Belsem; Marzouk, Zohra; Décor, Rachel; Edziri, Hayet; Haloui, Ehsen; Fenina, Nadia; Aouni, Mahjoub

doi:10.1016/j.jep.2009.04.025

Cited by 81 publications

(66 citation statements)

References 19 publications

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“…Estes compostos apresentaram atividade antifúngica específica para C. krusei. Estes dados podem ser comparados com estudo realizado por Marzouk et al, 26 que compararam componentes extraídos por diferentes solventes (acetona e água) pelo processo de turbólise a partir dos frutos maduros e imaturos, bem como das folhas de Citrullus colocynthis Schrad.…”

Section: Resultsunclassified

Planejamento experimental na otimização da extração dos frutos de Syzygium cumini (L.) skeels

Migliato¹,

Corrêa²,

Salgado³

et al. 2011

Quím. Nova

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Recebido em 14/5/10; aceito em 11/10/10; publicado na web em 9/2/11 FACTORIAL DESIGN OF THE OPTIMIZATION EXTRACTION OF Syzygium cumini (L.) Skeels FRUITS. The aim of this study was to standardize the extractive solution of Syzygium cumini. The extractive solution was selected through a full factorial design, considering the extraction method (maceration-5-days, turbo extraction, percolation), extractor solvent (ethanol 50, 70, 96%) and plant material particle size 0.302 mm into a plant:solvent ratio (1:10), using the dried residue and antimicrobial activity determination as evaluation criteria. The tests were performed in triplicate. It appeared that the percolation is the best procedure extractive, and ethanol mixture: water (50:50) the best solvent. ANOVA analysis showed the importance of these parameters.Keywords: Syzygium cumini; extraction method; factorial design. INTRODUÇÃOO desenvolvimento de fitoterápicos inclui várias etapas e processos interdisciplinares e multidisciplinares. As áreas de conhecimento envolvidas vão desde a antropologia botânica, botânica, agronomia, ecologia, química, fitoquímica, farmacologia, toxicologia, biotecnologia, química orgânica, tecnologia farmacêutica até ensaios clínicos. 1Dados da literatura revelam que é muito mais provável encontrar atividade biológica em plantas orientadas pelo seu uso na medicina popular (etnofarmacologia) do que em plantas escolhidas ao acaso.Para o conhecimento das substâncias ativas de plantas, um dos aspectos que deve ser observado consiste na preparação de extratos vegetais, visando o isolamento de seus constituintes químicos ativos. Um dos métodos que pode ser considerado adequado para a análise químico-farmacológica é a preparação de extratos hidroetanólicos 50% por maceração. Este extrato é análogo às tinturas realizadas na cultura popular, onde se misturam as partes ativas das plantas com bebidas alcoólicas.

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Section: Resultsunclassified

Planejamento experimental na otimização da extração dos frutos de Syzygium cumini (L.) skeels

Migliato¹,

Corrêa²,

Salgado³

et al. 2011

Quím. Nova

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“…Nadimi et al reported that aqueous and ethanolic extracts of Teucrium polium had effect on C. albicans and Malassezia [9]. Marzouk et al showed that Citrullus colocynthis had anti-bacterial and anti-candidal properties [10].…”

Section: Introductionmentioning

confidence: 99%

In vitro Antifungal Activity of Cucumis melo on Candida albicans

Azizi

Rouhi

Yahyayi

2015

Zahedan J Res Med Sci

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Background: With respect to the emergence of susceptibility of some fungi to antifungal agents, making use of medicinal plants is progressing. Objectives: The aim of this study was to verify the anti-fungal characteristics of mature and immature Cucumis melo fruit on Candida albicans. Materials and Methods: In this descriptive study, antifungal activity of aqueous, ethnolic and methanolic extracts of C. melo fruits were tested on C. albicans; also results were obtained by disc and well diffusion methods. Results: Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of mature C. melo fruit methanolic extract were 25 × 10 3 and 5 × 10 4 μg/mL, respectively. MIC and MFC of immature fruit methanolic extract was 25 × 10 3 . For mature fruit ethanolic extract, MIC and MFC was 25 × 10 3 μg/mL and for immature C. melo fruit ethanolic extract MIC was 25 × 10 3 and MFC was 5 × 10 4 μg/mL. Gas chromatography/mass spectrometry (GC/MS) results showed that hexadecanoic acid was present in all of the extracts. The maximum size of inhibition zone for mature and immature methanolic extact in the disc method was 12 mm and in well method were 15 and 17 mm, respectively. In the disc method, for mature and immature ethanolic extracts maximum size of inhibition zones were 35 and 36 mm and in the well method, maximum size of inhibition zones for mature and immature ethanolic extracts were 28 and 15 mm, respectively. Conclusions: These results indicated that C. melo extracts contain compounds with therapeutic potential and anti-fungal characteristics against C. albicans.

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“…Tangerine and watermelon seed possesses therapeutic activities against a wide range of ailment including inflammatory disorders, arthritis, and gout (Marzouk et al 2009). Microbial contamination reduces the shelf life of foods and increases the risk of food-borne illness.…”

Section: Introductionmentioning

confidence: 99%

Susceptibility of foodborne Pathogens and Spoilage Microorganisms to seed extracts of Citrullus Vulgaris and Citrus Reticulata

Omogbai

Ahonsi

2015

J bio-sci.

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Context: The importance of herbs in the management of food borne pathogens and spoilage organisms is of current interest since many plant components are bioactive and relatively safe when taken. Plant parts of Citrus reticulata and Citrullus vulgaris are used in herbal therapy in some parts of the world. Objective: The objective of this study was to evaluate the susceptibility of foodborne pathogens and spoilage microorganisms to seed extracts of Citrus reticulata and Citrullus vulgaris. Materials and Methods: The antimicrobial effect of ethanol and hot water extracts of C reticulata and C vulgaris seeds were studied using agar well diffusion technique. Minimum inhibitory concentration was performed using the modified tube dilution technique. The extracts were assayed on pure cultures of Bacillus subtilis, Staphylococcus aureus, Salmonella typhi, Escherichia coli, Saccharomyces cerevisiae and Aspergillus flavus. Results: Extracts tested at various concentrations produced in-vitro antimicrobial activities against foodborne isolates of B subtilis, S aureus, S typhi, E coli, S cerevisiae and A flavus.The highest zone of inhibition was obtained from ethanol extract at 4000µg/ml against B subtilis with diameter of 25mm for C reticulata. The lowest zone of inhibition of 10mm was obtained for E coli at 4000g/ml for the hot water extract of C vulgaris. The minimum inhibitory concentration (MIC) of the water extract of C reticulata and C vulgaris seeds ranged between 125-2000µg/ml. The MIC of the ethanol extract of the seeds of both plants was in the range 62.5-1000µg/ml.Comparatively, the ethanol extract of the seeds were more potent than the hot aqueous extract. The percent killing of the ethanol extract at 2000µg/ml was higher for C reticulata (45.6-100%) compared to that of C vulgaris (35.6-87.5). Conclusion:The results show that the ethanol extracts of Citrus reticulata and Citrullus vulgaris have potentential application for shelf life extension and as a pharmaceutical preparation.

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Antibacterial and anticandidal screening of Tunisian Citrullus colocynthis Schrad. from Medenine

Cited by 81 publications

References 19 publications

Planejamento experimental na otimização da extração dos frutos de Syzygium cumini (L.) skeels

Planejamento experimental na otimização da extração dos frutos de Syzygium cumini (L.) skeels

In vitro Antifungal Activity of Cucumis melo on Candida albicans

Susceptibility of foodborne Pathogens and Spoilage Microorganisms to seed extracts of Citrullus Vulgaris and Citrus Reticulata

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