Antibacterial activity study of 1,2,4-triazole derivatives

Gao, Feng; Wang, Tengfei; Xiao, Jiaqi; Huang, Gang

doi:10.1016/j.ejmech.2019.04.043

Cited by 216 publications

(98 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[13,14] 1,2,4-Triazoles chemistry are fascinating heterocycles and their derivatives specially they belong to isothiocyanates (ITCs) [15][16][17][18][19][20][21] class. Also, they possess significant pharmacological activities such as antitumor, [22] antifungal, [23] antiviral, [24] stimulants sedatives, [25][26] anti-inflammatory, [27] and antimycotic agents, [28] for example, 1 fluconazole, 2 voriconazole, 3 Fluconazole, 4 itraconazole, 5 Triazolam, 6 Alprazolam, and 7 Etizolam (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Nano nickel [1,2,4]‐triazole‐3‐thiones complex: Design, sonochemical synthesis, and antimicrobial evaluation

Farag

Hemdan

El‐Sayed

2020

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

A series of new 1,2,4‐triazole‐3‐thiones were synthesized by calm, benign, no risk, eco‐friendly, and energy efficient sequential reaction methodology like grinding and ultrasonic (US). In addition, 1,2,4‐triazoles were prepared under conventional method and comparative study was done. The synthesized 1,2,4‐triazoles were complexed with Ni(II) to produce nanoparticles complexes (NPC's) with average particle size vary from 55 to 100 nm (using scanning electron microscope technique) with good yields via both US and conventional techniques. X‐ray diffraction technique and spectra analysis techniques were used to confirm the square planer geometry of the synthesized NPC's. Antimicrobial activity of the prepared 1,2,4‐triazoles and their nickel complexes were studied which evaluated a high activity with complexes instead their triazoles.

show abstract

Section: Introductionmentioning

confidence: 99%

Nano nickel [1,2,4]‐triazole‐3‐thiones complex: Design, sonochemical synthesis, and antimicrobial evaluation

Farag

Hemdan

El‐Sayed

2020

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

show abstract

“…1,2,3‐Triazole and 1,2,4‐triazole, consisting of five‐membered ring of two carbon atoms and three nitrogen atoms, are major pharmacophore systems among nitrogen‐containing heterocycles. [ 37,38 ] 1,2,3‐Triazole and 1,2,4‐triazole derivatives possess promising in vitro and in vivo antibacterial activity against both drug‐sensitive and drug‐resistant organisms, [ 39,40 ] so hybridization of coumarin with triazole moiety might be an effective method for the development of novel antibacterial agents (Figure 2).…”

Section: Coumarin–triazole Hybridsmentioning

confidence: 99%

Coumarin‐containing hybrids and their antibacterial activities

Feng

Zhang

Yang

et al. 2020

Archiv der Pharmazie

View full text Add to dashboard Cite

Infections caused by Gram-positive and -negative bacteria are one of the foremost causes of morbidity and mortality globally. Antibiotics are the mainstay of therapy for bacterial infections, but the emergence and wide spread of drug-resistant pathogens have already become a huge issue for public healthcare systems. The coumarin moiety, which is ubiquitous in nature, could bind to the B subunit of DNA gyrase in bacteria and inhibit DNA supercoiling by blocking the ATPase activity; hence, coumarin derivatives possess potential antibacterial activity. Several coumarin-containing hybrids such as coumermycin A1, clorobiocin, and novobiocin have already been used in clinical practice for the treatment of various bacterial infections; thus, it is conceivable that hybridization of the coumarin moiety with other antibacterial pharmacophores may provide opportunities for the development of novel antibiotics. This review outlines the advances in coumarin-containing hybrids with antibacterial potential in the recent 5 years and the structure-activity relationships are also discussed. K E Y W O R D S antibacterial, coumarin, hybrid compounds, structure-activity relationships

show abstract

“…Azoles could induce apoptosis through the mitochondria‐mediated intrinsic pathway, the death receptor‐mediated extrinsic pathway, activation of caspases 3 and 7, inhibition of cyclin‐dependent kinase, aurora kinase, polo‐like kinase, cyclo‐oxygenase, EGFR, and disruption of the microtubule organization, so azole moiety is a common pharmacophore in the discovery of new anticancer agents. [ 32,72–74 ] Moreover, azole‐containing compounds such as bleomycin, carboxyamidotriazole, cefatrizine, tiazofurin, and tozasertib have been frequently employed as clinical drugs for the treatment of various cancers. Obviously, hybridization of isatin with azole may provide attractive scaffolds for development of novel anticancer agents.…”

Section: Isatin–coumarin Hybridsmentioning

confidence: 99%

Recent advances in isatin hybrids as potential anticancer agents

Ding

Zhou

Zeng

2020

Archiv der Pharmazie

View full text Add to dashboard Cite

The isatin framework is a useful template for the development of novel anticancer agents. This is exemplified by the fact that several isatin‐based anticancer agents, such as semaxanib, sunitinib, nintedanib, and hesperadin, are already in use or under clinical trials for the treatment of diverse kinds of cancers. Isatin‐based hybrids could be obtained by incorporating other anticancer pharmacophores into the isatin skeleton and they have the potential to overcome drug resistance with reduced side effects. Thus, isatin‐based hybrids may provide attractive scaffolds for the development of novel anticancer agents. This review covers the recent advances of isatin‐based hybrids with anticancer activity, covering articles published between 2001 and 2019. The anticancer activities of these molecules and the structure–activity relationships are also discussed. The purpose of this review article is to set up the direction for the design and development of isatin‐based hybrids with high efficacy and low toxicity.

show abstract

Antibacterial activity study of 1,2,4-triazole derivatives

Cited by 216 publications

References 97 publications

Nano nickel [1,2,4]‐triazole‐3‐thiones complex: Design, sonochemical synthesis, and antimicrobial evaluation

Nano nickel [1,2,4]‐triazole‐3‐thiones complex: Design, sonochemical synthesis, and antimicrobial evaluation

Coumarin‐containing hybrids and their antibacterial activities

Recent advances in isatin hybrids as potential anticancer agents

Contact Info

Product

Resources

About