Coumarin‐containing hybrids and their antibacterial activities

Feng, Dongxu; Zhang, Aihua; Yang, Yuan; Yang, Peng

doi:10.1002/ardp.201900380

Cited by 79 publications

(39 citation statements)

References 128 publications

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“…It is suggested that the prenylation in C8 and OH group in C7 may increase the antibacterial activity of coumarins [ 49 ]. The activity of coumarins and coumarin derivatives on S. aureus , including methicillin-resistant Staphylococcus aureus strains (MRSA), is explained by the binding of coumarin moiety ( Figure 2 ) to the B subunit of DNA gyrase [ 50 , 51 ]. Coumarins are major constituents in the plants of the genus Melilotus .…”

Section: Medicinal Plants and Their Constituents With Antibacterial Activity Intended In The Treatment Of Skin Disorders According To Eurmentioning

confidence: 99%

Antibacterial Activity of Medicinal Plants and Their Constituents in the Context of Skin and Wound Infections, Considering European Legislation and Folk Medicine—A Review

Fialová

Rendeková

Mučaji

et al. 2021

IJMS

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Bacterial infections of skin and wounds may seriously decrease the quality of life and even cause death in some patients. One of the largest concerns in their treatment is the growing antimicrobial resistance of bacterial infectious agents and the spread of resistant strains not only in the hospitals but also in the community. This trend encourages researchers to seek for new effective and safe therapeutical agents. The pharmaceutical industry, focusing mainly on libraries of synthetic compounds as a drug discovery source, is often failing in the battle with bacteria. In contrast, many of the natural compounds, and/or the whole and complex plants extracts, are effective in this field, inactivating the resistant bacterial strains or decreasing their virulence. Natural products act comprehensively; many of them have not only antibacterial, but also anti-inflammatory effects and may support tissue regeneration and wound healing. The European legislative is in the field of natural products medicinal use formed by European Medicines Agency (EMA), based on the scientific work of its Committee on Herbal Medicinal Products (HMPC). HMPC establishes EU monographs covering the therapeutic uses and safe conditions for herbal substances and preparations, mostly based on folk medicine, but including data from scientific research. In this review, the medicinal plants and their active constituents recommended by EMA for skin disorders are discussed in terms of their antibacterial effect. The source of information about these plant products in the review is represented by research articles listed in scientific databases (Science Direct, PubMed, Scopus, Web of Science, etc.) published in recent years.

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Section: Medicinal Plants and Their Constituents With Antibacterial Activity Intended In The Treatment Of Skin Disorders According To Eurmentioning

confidence: 99%

Antibacterial Activity of Medicinal Plants and Their Constituents in the Context of Skin and Wound Infections, Considering European Legislation and Folk Medicine—A Review

Fialová

Rendeková

Mučaji

et al. 2021

IJMS

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“…[ 33,34 ] Coumarins have the ability to bind to the B subunit of DNA gyrase in bacteria and inhibit DNA supercoiling via blocking the ATPase activity. [ 35,36 ] Many coumarin‐based drugs like clorobiocin and novobiocin have already been used in clinics for fighting against infections caused by various pathogens including drug‐resistant strains, [ 37,38 ] revealing the potential of coumarins as putative antibiotics. Thus, the hybridization of indole/isatin with coumarin may provide opportunities for the development of novel antibacterial agents.…”

Section: Indole/isatin–coumarin Hybridsmentioning

confidence: 99%

Indole/isatin‐containing hybrids as potential antibacterial agents

Song

Bian

et al. 2020

Archiv der Pharmazie

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The emergence and worldwide spread of drug-resistant bacteria have already posed a serious threat to human life, creating the urgent need to develop potent and novel antibacterial drug candidates with high efficacy. Indole and isatin (indole-2,3-dione) present a wide structural and mechanistic diversity, so their derivatives possess various pharmacological properties and occupy a salient place in the development of new drugs. Indole/isatin-containing hybrids, which demonstrate a promising activity against a panel of clinically important Gram-positive and Gram-negative bacteria, are privileged scaffolds for the discovery of novel antibacterial candidates. This review, covering articles published between January 2015 and May 2020, focuses on the development and structure-activity relationship (SAR) of indole/isatincontaining hybrids with potential application for fighting bacterial infections, to facilitate further rational design of novel drug candidates.

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“…Coumarin derivatives could inhibit ATPase activity of DNA gyrase by competing with adenosine triphosphate for binding to the B subunit of the enzyme, and some coumarin‐containing compounds such as novobiocin and clorobiocin are known as antibacterial agents. [ 42,43 ] Therefore, hybridization of 1,2,4‐triazole with coumarin moiety may provide dual/multiple‐acting antibacterial candidates, which are useful for the treatment of MRSA infections.…”

Section: 24‐triazole–coumarin Hybridsmentioning

confidence: 99%

1,2,4‐Triazole hybrids with potential antibacterial activity against methicillin‐resistant Staphylococcus aureus

2020

Archiv der Pharmazie

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Methicillin‐resistant Staphylococcus aureus (MRSA) has developed numerous mechanisms of virulence and strategies to evade the human immune system, and it can be transmitted between humans, animals, and the environment. Thus, MRSA is an important cause of morbidity and mortality in both hospitals and in the community, creating an urgent demand for the development of novel anti‐MRSA candidates. The 1,2,4‐triazole nucleus is a bioisostere of amide, ester, and carboxylic acid, and the 1,2,4‐triazole ring is found in many compounds with diverse biological effects. 1,2,4‐Triazole derivatives could exert their antibacterial activity through inhibition of efflux pumps, filamentous temperature‐sensitive protein Z, penicillin‐binding protein, DNA gyrase, and topoisomerase IV, and they play an important role in the discovery of novel antibacterial agents. Among them, 1,2,4‐triazole hybrids, which have the potential to exert dual/multiple mechanisms of action, possess a promising broad‐spectrum antibacterial activity against a panel of clinically important drug‐resistant pathogens including MRSA. This review outlines the recent developments of 1,2,4‐triazole hybrids with a potential anti‐MRSA activity, covering articles published between 2010 and 2020. The mechanisms of action, critical aspects of their design, and structure–activity relationships are also discussed.

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Coumarin‐containing hybrids and their antibacterial activities

Cited by 79 publications

References 128 publications

Antibacterial Activity of Medicinal Plants and Their Constituents in the Context of Skin and Wound Infections, Considering European Legislation and Folk Medicine—A Review

Antibacterial Activity of Medicinal Plants and Their Constituents in the Context of Skin and Wound Infections, Considering European Legislation and Folk Medicine—A Review

Indole/isatin‐containing hybrids as potential antibacterial agents

1,2,4‐Triazole hybrids with potential antibacterial activity against methicillin‐resistant Staphylococcus aureus

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