Antibacterial activity of garlic extract on cariogenic bacteria: An in vitro study

Kshirsagar, Minal M; Dodamani, Arun Suresh; Karibasappa, Gundabaktha Nagappa; Vishwakarma, Prashanth; Vathar, Jagdishchandra Bheemasain; Sonawane, Kapil Ramesh; Jadhav, Harish; Khobragade, Vrushali R

doi:10.4103/ayu.ayu_193_16

Cited by 34 publications

(26 citation statements)

References 8 publications

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“…In recent in vitro study fresh soft neck and stiff neck garlic species were extracted with distilled water, and it was discovered that the bioactive component allyl 2 propenethiosulfinate or diallyl thiosulfinate present in GE has antibacterial activity against the cariogenic bacteria Lactobacillus acidophilus (MTCC 10307) and Streptococcus mutans (MTCC 497) with the greatest zone of inhibition of 24 mm. As a result, it may be a valuable resource for treating dental caries and other oral illnesses [ 104 ].…”

Section: Oral Pathologies and Beneficial Role Of Ge In The Alleviationmentioning

confidence: 99%

Garlic (Allium sativum L.) Bioactives and Its Role in Alleviating Oral Pathologies

Sasi

Kumar

et al. 2021

Antioxidants

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Garlic (Allium sativa L.) is a bulbous flowering plant belongs to the family of Amaryllidaceae and is a predominant horticultural crop originating from central Asia. Garlic and its products are chiefly used for culinary and therapeutic purposes in many countries. Bulbs of raw garlic have been investigated for their role in oral health, which are ascribed to a myriad of biologically active compounds such as alliin, allicin, methiin, S-allylcysteine (SAC), diallyl sulfide (DAS), S-ally-mercapto cysteine (SAMC), diallyl disulphide (DADS), diallyl trisulfide (DATS) and methyl allyl disulphide. A systematic review was conducted following the PRISMA statement. Scopus, PubMed, Clinicaltrials.gov, and Science direct databases were searched between 12 April 2021 to 4 September 2021. A total of 148 studies were included and the qualitative synthesis phytochemical profile of GE, biological activities, therapeutic applications of garlic extract (GE) in oral health care system, and its mechanism of action in curing various oral pathologies have been discussed. Furthermore, the safety of incorporation of GE as food supplements is also critically discussed. To conclude, GE could conceivably make a treatment recourse for patients suffering from diverse oral diseases.

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Section: Oral Pathologies and Beneficial Role Of Ge In The Alleviationmentioning

confidence: 99%

Garlic (Allium sativum L.) Bioactives and Its Role in Alleviating Oral Pathologies

Sasi

Kumar

et al. 2021

Antioxidants

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“…Garlic has outstanding therapeutic applications, including anti-cancer, hypoglycemic, antibiotic, and anti-inflammatory effects. Furthermore, some of the literature has suggested that garlic cloves have an array of therapeutic benefits, with antifungal, antibacterial, and antiviral properties [ 32 ]. Hence, it is reasonable to infer that the selenium nanoparticles capped and stabilized with essential metabolites present in garlic cloves extract may represent a nanoparticle with remarkable antimicrobial significance.…”

Section: Introductionmentioning

confidence: 99%

Phytogenic Selenium Nanoparticles Elicited the Physiological, Biochemical, and Antioxidant Defense System Amelioration of Huanglongbing-Infected ‘Kinnow’ Mandarin Plants

et al. 2022

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Citrus greening or huanglongbing (HLB) is commonly known as yellow dragon disease and affects citrus production worldwide. Therefore, it has a significant impact on and deleterious effects in the agro-industrial sector. Significant efforts have been made to combat this disease and mitigate its destructive impact on citrus production, but still, there is no effective biocompatible treatment available to control HLB disorder. This study is considered the first biocompatible approach to evaluate the potential of phytogenic selenium nanoparticles (SeNPs) to improve the health of HLB-infected ‘Kinnow’ mandarin plants. Polymerase chain reactions (PCRs) with specific primers were used to detect HLB disease in ‘Kinnow’ mandarin plants, and PCR products were sequenced to identify Candidatus Liberibacter asiaticus (CLas), and accession numbers for CLas1 and CLas2, MZ851933 and MZ851934, respectively, were obtained. SeNPs were synthesized by using Allium sativum L. clove extract as a reducing, capping, and stabilizing agent and various techniques such as UV-visible spectrophotometry, energy dispersive X-rays, scanning electron microscopy (SEM), Fourier transformed infrared spectroscopy (FTIR), and X-ray diffraction analysis (XRD) were used to confirm the biogenesis of SeNPs. Different concentrations of SeNPs (25, 50, 75, and 100 mg L–1) were exogenously applied to HLB-infected ‘Kinnow’ mandarin plants and obtained spectacular results. The obtained results from the current study proved that 75 mg L–1 of SeNPs was most effective to improve the chlorophyll, carotenoids, relative water content (RWC), membrane stability index (MSI), total soluble sugar (TSS), superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), total flavonoid content (TFC), and total phenolic content (TPC) and significant decrease was observed in hydrogen peroxide (H2O2), malondialdehyde (MDA), and proline (PRO) contents of HLB-infected ‘Kinnow’ mandarin plants as compared to untreated diseased citrus plants. In conclusion, these results allow us to synthesize the SeNPs formulation as a promising management strategy to treat the HLB disease in citrus plants.

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“…Resistance to the antibacterial drugs is seen in most of the bacterial species. 8 This study showed that 100% concentration of the Eucalyptus globulus extract shows a comparatively maximum inhibition zone against P. gingivalis and A. actinomycetemcomitans . The study has been done recently by Nagata et al 9 on virulence factors of Porphyromonas gingivalis , including Arg and Lys specific cysteine proteinases.…”

Section: Discussionmentioning

confidence: 83%

An In Vitro Evaluation of Antibacterial Efficacy of Various Concentration of Eucalyptus globulus Leaf Extract on Periodontal Pathogens

Bankur

Mathew

Almalki

et al. 2019

The Journal of Contemporary Dental Practice

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Aim:The aim of the present study was to evaluate the antibacterial efficacy of various concentrations of Eucalyptus globulus leaf extract on periodontal pathogens. Materials and methods: Matured, healthy and disease-free leaves of Eucalyptus globulus were collected. The leaves were washed under tap water and finally dried in an oven at a temperature of 45°C for 48 hours. The dried plants were ground in an electric blender to make them into a powder. The powder was mixed with 100% ethanol and kept it inside a shaker overnight at 35°C. The mixture was centrifuged for 10 minutes at 2,500 rpm. Three different concentrations (10%, 50%, and 100% v/v) were used as antibacterial agents. Chlorhexidine (0.2%) was considered as positive control and dimethyl formamide was considered as negative control against P. gingivalis and A. actinomycetemcomitans . The disc diffusion method was used to determine the extract's antibacterial activity against the test organisms. A digital Vernier caliper was used to measure the diameter of antibacterial activity showing the zone of inhibition in millimeters. Results: Eucalyptus globulus with 100% concentration showed a maximum zone of inhibition against A. actinomycetemcomitans and P. gingivalis (5.38 ± 0.32 mm, 4.82 ± 0.11 mm) followed by 50% and 10% accordingly. The negative control of dimethyl formamide showed a zone of inhibition of 0.48 ± 0.96 mm and 0.63 ± 0.20 mm against A. actinomycetemcomitans and P. gingivalis . The positive control of 0.2% chlorhexidine showed a zone of inhibition of 8.46 ± 1.02 mm and 7.18 ± 0.54 mm against A. actinomycetemcomitans and P. gingivalis . The ANOVA test showed a highly significant antibacterial efficacy in 0.2% chlorhexidine and 100% concentration Eucalyptus globulus . Conclusion: A significant maximum zone of inhibition against A. actinomycetemcomitans and P. gingivalis was showed by 100% concentration of Eucalyptus globulus . Clinical significance: Other than the systemic diseases treatment, Eucalyptus globulus also serves as an effective promising alternative to antibiotics in the prevention of oral infections because of the natural phytochemicals existing in them.

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Antibacterial activity of garlic extract on cariogenic bacteria: An in vitro study

Cited by 34 publications

References 8 publications

Garlic (Allium sativum L.) Bioactives and Its Role in Alleviating Oral Pathologies

Garlic (Allium sativum L.) Bioactives and Its Role in Alleviating Oral Pathologies

Phytogenic Selenium Nanoparticles Elicited the Physiological, Biochemical, and Antioxidant Defense System Amelioration of Huanglongbing-Infected ‘Kinnow’ Mandarin Plants

An In Vitro Evaluation of Antibacterial Efficacy of Various Concentration of Eucalyptus globulus Leaf Extract on Periodontal Pathogens

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