Antibacterial Activity and Physical Properties of Conventional Glass-ionomer Cements Containing Chlorhexidine Diacetate/Cetrimide Mixtures

Tüzüner, Tamer; Kuşgöz, Adem; Er, Kürşat; Taşdemir, Tamer; Buruk, Kurtulus; Kemer, Barış

doi:10.1111/j.1708-8240.2010.00385.x

Cited by 43 publications

(63 citation statements)

References 33 publications

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“…Release equilibrated after approximately 2 weeks, at which time substantial amounts of antimicrobial compound remained in the cement. Similar behavior has been observed in other dental materials, including composite resins (4,5) and cements (6,8,14).…”

Section: Discussionsupporting

confidence: 58%

Release of antimicrobial compounds from a zinc oxide-chelate cement

et al. 2018

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This study examined the release of cetylpyridinium chloride and benzalkonium chloride from fatty acid chelate temporary dental cement and their antimicrobial effects. The cement was Cavex Temporary, and either cetylpyridinium chloride or benzalkonium chloride was added (1% or 5% by mass), incorporating into the base paste. Release of the additives was determined by reverse-phase high-performance liquid chromatography. Possible chemical interactions between the cement components and additives were examined by Fourier transform infrared (FTIR) spectroscopy. Antimicrobial effects were assessed by measuring the zone of inhibition around sample discs after 24 h in a Streptococcus mutans culture. FTIR spectroscopy showed no interaction with cement components. For both additives, release was by diffusion for approximately the first 6 hours, with equilibration after about 2 weeks. Diffusion coefficients were 1.76 m 2 s ½ to 8.05 × 10 −12 m 2 s ½ and total release was 10.3 to 44.7% of additive loading. Zones of inhibition with additive were significantly larger than those for control discs. In conclusion, the antimicrobial properties of Cavex temporary cement are improved by the addition of the antimicrobial compounds cetylpyridium chloride and benzalkonium chloride, which are released by a diffusion process.

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Section: Discussionsupporting

confidence: 58%

Release of antimicrobial compounds from a zinc oxide-chelate cement

et al. 2018

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“…In the past decade, antimicrobial agents have been incorporated into dental materials to lend them antimicrobial activity [33,34]. The incorporation of CHX and/or CTR into glass ionomer cement (GIC) is known to confer it with beneficial antibacterial properties [34].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of alexidine, chlorhexidine and cetrimide against Streptococcus mutans biofilm

Ruiz-Linares¹,

Baca²,

Arias-Moliz³

et al. 2014

J Clin Exp Dent

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Background: The use of antimicrobial solutions has been recommended to disinfect demineralized dentin prior to placing the filling material. The aim of this study was to evaluate the ability of several antimicrobials in controlling Streptococcus mutans (SM) biofilm formed in dentin. Methods: Antimicrobial activity of 0.2% and 2% chlorhexidine (CHX), 0.2% cetrimide (CTR) and 0.2%, 0.5%, 1% and 2% alexidine (ALX) was assayed on 1-week SM biofilm formed on standardized coronal dentin blocks. Results of SM biofilm antimicrobial activity by different protocols were expressed as the kill percentage of biofilm and the term "eradication" was used to denote the kill of 100% of the bacterial population. To compare the efficacies of the different protocols the Student t test was used, previously subjecting data to the Anscombe transformation.Results: All ALX concentrations tested and 0.2% CTR achieved a kill percentage higher than 99%, followed by 2% CHX with percentages above 96% (no statistically significant difference among them). Whereas 2% ALX and 0.2% CTR respectively showed eradication in 10 and 9 of the twelve specimens, 0.2% CHX did not produce eradication in any case.Conclusions: The present study shows that, when used for one minute, 2% and 1% alexidine, and 0.2% cetrimide, achieve eradication of Streptococcus mutans biofilm in most specimens when applied to a dentin-volumetric model.

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“…The GICs indicated for ART have shown reduced antimicrobial activity 5,6,14,15 , and for this reason, the incorporation of antimicrobial agents (chlorhexidine and antibiotics) to the cement has been suggested in several investigations 1,6,[14][15][16][17][18] , in order to increase the effect of these materials against residual microorganisms on cavities after partial caries removal. Chlorhexidine is the antimicrobial agent commonly used in Dentistry due its safety and broad-spectrum bactericidal effect, affecting the growth of gram-positive bacteria especially oral streptococci 19 , gram-negative bacteria, fungi and yeasts, facultative aerobic and anaerobic species 20 .…”

Section: Introductionmentioning

confidence: 99%

Effect of storage time and chlorhexidine addition on the mechanical properties of glass ionomer cements

Machado¹,

Duque²,

Oliveira³

et al. 2017

Braz. J. Oral Sci.

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Aims:To evaluate the effect of the chlorhexidine (CHX) incorporation and the storage time on the mechanical properties of glass ionomer cements (GICs). Methods: The following GICs were evaluated: Ketac Molar Easymix (KM), Vidrion R (VR) and Vitromolar (VM), containing or not CHX. GIC liquid was modified by adding 1.25 % CHX digluconate and then manipulated with the power and placed into the stainless steel cylindrical or bar-shaped molds. GICs specimens were stored into water for 1, 7 and 28 days. After these periods, specimens were submitted to flexural, diametral tensile and compressive strength tests, according to ISO standards. Data from mechanical tests were statistically analyzed using 2-way ANOVA and Tukey tests. Results: Overall, the storage time did not influence any of the mechanical properties of the GICs tested. In contrast, the inclusion of CHX reduced significantly these properties for all GICs tested. KM presented the highest values of compressive strength for all storage times. KM + 1.25% CHX had lower compressive strength results than KM, however, it showed similar results when compared to another GICs without CHX. Conclusions: The presence of chlorhexidine, independent of the storage time, interfered on the mechanical characteristics of GIC.

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Antibacterial Activity and Physical Properties of Conventional Glass-ionomer Cements Containing Chlorhexidine Diacetate/Cetrimide Mixtures

Cited by 43 publications

References 33 publications

Release of antimicrobial compounds from a zinc oxide-chelate cement

Release of antimicrobial compounds from a zinc oxide-chelate cement

Antimicrobial activity of alexidine, chlorhexidine and cetrimide against Streptococcus mutans biofilm

Effect of storage time and chlorhexidine addition on the mechanical properties of glass ionomer cements

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