Release of antimicrobial compounds from a zinc oxide-chelate cement

Tüzüner, Tamer; Güçlü, Zeynep Aslı; Hurt, Andrew P.; Coleman, Nichola J.; Nicholson, John W.

doi:10.2334/josnusd.16-0791

Cited by 6 publications

(6 citation statements)

References 13 publications

(23 reference statements)

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“…[ 180,201,202 ] These entities have also been used in tissue regeneration and restorative dentistry to impart antimicrobial activity and enhance mechanical properties. [ 203–205 ]…”

Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

473

368

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Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface-colonized microbes pose serious problems to the society from both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or on the surface of materials, or by coatings, to prevent microbial adhesion or kill the microorganisms after their attachment to biofilms, represents an important strategy in an increasingly challenging field. Over the last decade, many studies have been devoted to preparing meta-based nanomaterials that possess antibacterial, antiviral, and antifungal activities to combat pathogen-related diseases. Herein, an overview on the state-of-the-art antimicrobial nanosized metal-based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets. The antimicrobial mechanism of these nanostructures and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry are discussed. Their properties as well as potential caveats such as cytotoxicity, diminishing efficacy, and induction of antimicrobial resistance of materials incorporating these nanostructures are reviewed to provide a backdrop for future research.

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“…[ 180,201,202 ] These entities have also been used in tissue regeneration and restorative dentistry to impart antimicrobial activity and enhance mechanical properties. [ 203–205 ]…”

Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

473

368

View full text Add to dashboard Cite

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“…Regarding the anti-gingivitis effects of the toothpastes; however, the testing would also have been interesting with gingivitis-or periodontitis-associated species. S. mutans was used to simplify comparisons with other studies, which most often apply this species in similar diffusion assays [20,[43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Toothpastes with Enzymes Support Gum Health and Reduce Plaque Formation

Paqué

Schmidlin

Wiedemeier

et al. 2021

IJERPH

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Enzymes in toothpastes can support host immune responses, and thus maintain oral health. This study aimed to investigate gingival health and the plaque-reducing effects of enzyme-containing toothpastes. A laboratory study tested the antimicrobial potential of different enzyme-containing toothpaste formulations. Two promising formulations (enzyme-containing toothpastes with glucose oxidase and D-glucose with (C+) and without Citrox (C−) Citrox) were investigated in a clinical crossover trial (two slurries: sodium lauryl sulfate-containing (SLS), a toothpaste without SLS (reference), and water). Subjects (n = 20) abstained from toothbrushing for four days and rinsed with a toothpaste slurry. Bleeding on probing (BOP) and plaque indices (PI) were measured. A mixed linear model was used to statistically compare the slurries with respect to BOP and PI change. The in vitro bacterial growth-inhibiting evaluation showed the best results for SLS, followed by C+ and C−. The change in BOP and PI exhibited statistically significant differences to water rinsing (BOP; PI changes in % points (difference of the baseline and post-rinse values: water = 8.8%; 90.0%; C+ = −1.4%; 80.4%; SLS = 1.5%; 72.1%; reference = 0.8%; 77.5%; C− = −1.8%; 75.1%). All slurries exhibited anti-gingivitis and anti-plaque effects, resulting in a prophylactic benefit for limited-access regions during brushing.

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“…Additionally, these results show that it is not necessary to observe significant changes in ATR-FTIR and XPS spectra after CHX addition to obtain a significant antibacterial effect, which is similar to what was observed for benzalkonium chloridecontaining dental cement. 39…”

Section: Antibacterial Assaymentioning

confidence: 99%

“…37,38 However, a similar behavior was observed for dental cement, as the addition of the antibacterial agent benzalkonium chloride did not result in changes in the FTIR spectrum, although it made the material antibacterial. 39 The small shifts could probably be attributed to the interaction of the CHX molecules and the PU.…”

Section: Chemical Analysis Of the Cnys And Quantification Of Incorporated Chx In The Cnysmentioning

confidence: 99%

Composite yarns with antibacterial nanofibrous sheaths produced by collectorless alternating‐current electrospinning for suture applications

Madheswaran

Sivan

Valtera

et al. 2021

J of Applied Polymer Sci

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Fabrication of strong antibacterial composite nanofibrous yarns (CNYs) for suture applications by using common direct current electrospinning has been technologically challenging. In this work, we have demonstrated a more straightforward and facile approach to fabricate chlorhexidine (CHX)containing antibacterial nanofibrous sheaths wounded around a polyamide core yarn using a novel collectorless alternating-current electrospinning approach. Scanning electron microscopy results showed that the nanofibrous envelope was completely wrapped around the core yarn for both polymers, polyurethane, and polyamide 6 (PA6), used in this study. High-performance liquid chromatography after dissolving of the CNYs confirmed the presence of CHX in the yarns, while X-ray photoelectron spectroscopy and Fouriertransform infrared spectroscopy indicated that the amount is relatively low. The tensile properties of all the CNYs were better than of the core yarns and the CHX addition resulted in a lower envelope linear density and envelope adhesion force. Thermal gravimetric analysis showed that all CNYs are thermally stable within the temperature range of interest. Cytocompatibility tests with 3T3-SA mouse fibroblast cells and antibacterial evaluations with Escherichia coli and Staphylococcus aureus showed that the CHX-containing PA6-based CNYs are biocompatible and have antibacterial properties, suggesting that these yarns can be used as functional and mechanically performant sutures.

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Release of antimicrobial compounds from a zinc oxide-chelate cement

Cited by 6 publications

References 13 publications

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Toothpastes with Enzymes Support Gum Health and Reduce Plaque Formation

Composite yarns with antibacterial nanofibrous sheaths produced by collectorless alternating‐current electrospinning for suture applications

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