Antibacterial activities of β-glucan (laminaran) against gram-negative and gram-positive bacteria

Chamidah, Anies; Hardoko, Hardoko; Prihanto, Asep Awaludin

doi:10.1063/1.4983422

Cited by 23 publications

(11 citation statements)

References 15 publications

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“…β-Glucans also exhibited in vitro antimicrobial activity [ 21 , 22 , 23 ], directly against a broad range of bacterial species, including Escherichia coli , Pseudomonas aeruginosa and Staphylococcus aureus , or indirectly by enhancing macrophage phagocytic activity and resistance to bacterial challenge [ 24 , 25 ]. In another study, β-glucan from oats also showed antimicrobial effects against Escherichia coli and Bacillus subtilis [ 21 ].…”

Section: Wound Healing Activity Of β-Glucans: In Vitro Experimentsmentioning

confidence: 99%

β-Glucans: Multi-Functional Modulator of Wound Healing

Majtán

Jeseňák

2018

Molecules

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β-glucans are derived from a variety of sources including yeast, grain and fungus and belong to the class of drugs known as biological response modifiers. They possess a broad spectrum of biological activities that enhance immunity in humans. One promising area for β-glucans’ application is dermatology, including wound care. Topical applications of β-glucans are increasing, especially due to their pluripotent properties. Macrophages, keratinocytes and fibroblasts are considered the main target cells of β-glucans during wound healing. β-glucans enhance wound repair by increasing the infiltration of macrophages, which stimulates tissue granulation, collagen deposition and reepithelialization. β-glucan wound dressings represent a suitable wound healing agent, with great stability and resistance to wound proteases. This review summarizes the current knowledge and progress made on characterizing β-glucans’ wound healing properties in vitro and in vivo and their safety and efficacy in managing non-healing wounds or other chronic dermatological conditions and diseases.

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Section: Wound Healing Activity Of β-Glucans: In Vitro Experimentsmentioning

confidence: 99%

β-Glucans: Multi-Functional Modulator of Wound Healing

Majtán

Jeseňák

2018

Molecules

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“…They are used in medicine as natural preparations with antitumor properties, which decrease the levels of cholesterol and glucose in the serum and also stimulate the immune system [ 19 , 28 ]. The antibacterial properties of beta-glucans are also known and well described [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ], but little is known about their direct action on fungi and possible direct antifungal activity. So far, research has focused on understanding the interactions between host cells (mainly animal) and beta-glucan and the host anti-fungal immunity induced by this compound [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Study of Antifungal Properties of New Cationic Beta-Glucan Derivatives

et al. 2021

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The interaction of positively charged polymers (polycations) with a biological membrane is considered to be the cause of the frequently observed toxicity of these macromolecules. If it is possible to obtain polymers with a predominantly negative effect on bacterial and fungal cells, such systems would have great potential in the treatment of infectious diseases, especially now when reports indicate the growing risk of fungal co-infections in COVID-19 patients. We describe in this article cationic derivatives of natural beta-glucan polymers obtained by reacting the polysaccharide isolated from Saccharomyces boulardii (SB) and Cetraria islandica (CI) with glycidyl trimethyl ammonium chloride (GTMAC). Two synthesis strategies were applied to optimize the product yield. Fungal diseases particularly affect low-income countries, hence the emphasis on the simplicity of the synthesis of such drugs so they can be produced without outside help. The three structures obtained showed selective anti-mycotic properties (against, i.e., Scopulariopsis brevicaulis, Aspergillus brasiliensis, and Fusarium solani), and their toxicity established using fibroblast 3T3-L1 cell line was negligible in a wide range of concentrations. For one of the polymers (SB derivative), using in vivo model of Aspergillus brasiliensis infection in Galleria mellonella insect model, we confirmed the promising results obtained in the preliminary study.

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“…After 24 hours of incubation on the Luria Bertani broth medium, the medium was centrifuged on 2,500 rpm for 10 min at 4°C. Cell-free supernatants were tested for their antibacterial activity by using the disk-diffusion method [10]. e inhibition zones were observed after 24 hours of incubation.…”

Section: Identification Of Bacteriamentioning

confidence: 99%

Autochthonous Acid-Producing Bacteria from Catfish (Clarias sp.) with Antibacterial Activity against Selected Fish Pathogens: A Preliminary Study

Prihanto

Nursyam

Jatmiko

et al. 2020

International Journal of Microbiology

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In this study, the application of an autochthonous microorganism as probiotic on catfish (Clarias sp.) was scarcely reported. This study aimed to obtain probiotic candidates from the digestive tract (intestinal and gastric) of catfish. A total of nine isolates were successfully isolated from the catfish. Almost all bacterial colonies were morphologically round, had flat edges, were yellow, and produced clear zones as a sign of producing acid during culture. The analysis showed that the three isolates had the best activity in inhibiting fish pathogen isolates. Furthermore, molecular analysis revealed that those three isolates were Bacillus velezensis UB-C1, Bacillus amyloliquifaciens UB-C5, and Bacillus cereus UB-C8. Interestingly, those three bacteria were non-lactic acid bacteria.

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Antibacterial activities of β-glucan (laminaran) against gram-negative and gram-positive bacteria

Cited by 23 publications

References 15 publications

β-Glucans: Multi-Functional Modulator of Wound Healing

β-Glucans: Multi-Functional Modulator of Wound Healing

Synthesis and Study of Antifungal Properties of New Cationic Beta-Glucan Derivatives

Autochthonous Acid-Producing Bacteria from Catfish (Clarias sp.) with Antibacterial Activity against Selected Fish Pathogens: A Preliminary Study

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