Antiaging, photoprotective, and brightening activity in biorevitalization: a new solution for aging skin

Abstract

BackgroundAge-related changes in the dermis can be considered the result of intrinsic factors and the consequence of environmental damage, mainly due to ultraviolet (UV) radiation from the sun (responsible for skin photoaging). The great versatility of the mesotherapy “biorevitalization” lies in the synergy between different biological effects of the active injected substances, which treats the skin in a more complete way. Several studies about biorevitalization efficacy showed good results. To date, however, objective results supported by instrumental evaluation are very sparse.PurposeThis study evaluated the efficacy of an injectable solution (32 mg of hyaluronic acid plus an antiaging antioxidant complex consisting of vitamins, minerals, and amino acids) in the treatment of skin aging and photoaging.MethodsA total of 64 female volunteers (37–60 years) underwent four sessions of biorevitalization at 3-week intervals, involving multiple injections in the face (external corner of the eye and cheek), neck, décolletage, and back of the hands. The esthetic result was assessed at baseline and after 6, 9, and 12 weeks, and was established through the use of clinical and instrumental evaluations, supported by photographic documentation. Additionally, a phototest was performed to assess the effect of biorevitalization treatment on UVB-induced erythema.ResultsInstrumental assessment showed, as early as after the second biorevitalizing treatment, the antiaging efficacy of the tested product; there was a clinical and statistically significant improvement of profilometric parameters, skin brightness, pigmentation, and deep skin hydration. The study product induced a statistically significant decrease of the visual score of the UVB-induced erythema compared with baseline, which was statistically different from placebo.ConclusionThe study confirmed the well-known efficacy of biorevitalization in skin rejuvenation. The positive difference between deep and superficial skin hydration registered at the end of the trial suggested improved skin moisture retention of the stratum corneum. Furthermore, the obtained results suggest that the injected product could intervene at different moments of the skin pigmentation process by activating an intrinsic photoprotective mechanism and improving skin pigmentation quality. It may be that these processes employ common mechanisms in which antioxidants could play a pivotal role. This last hypothesis deserves further investigation.

Autologous platelet‐rich plasma versus readymade growth factors in skin rejuvenation: A split face study

“…The growing interest to maintain a youthful appearance prompted the development of new dermatological procedures for treatment of skin aging. In recent years, there has been an increasing emphasis on minimally invasive treatments and techniques designed to treat volume loss, wrinkles, and skin photodamage . Such procedures include mesotherapy and autologous PRP .…”

<p>Subjective Evaluation of the Results of Injectable Hyaluronic Acid Fillers for the Face</p>

“…Positive changes in the appearance of the facial skin after HA treatment (improved firmness and pigmentation) were observed by Landi et al 35 Trong et al 36 also documented improved skin elasticity and wrinkle depth reduction, while Baspeyras et al, 37 observed significant improvement in skin hydration, firmness and viscoelasticity after HA microinjection treatment. A statistically significantly improved radiance, pigmentation and hydration were observed by Sparavigna et al, 38 in the process of treating skin with symptoms of ageing and photoaging.…”

Clinical Assessment of a Mesotherapy Formulation for Skin Rejuvenation in Healthy Volunteers

“…The injected mixture was able to have an action on the skin pigmentation process with a photoprotective effect [19]. One can assume that antioxidants, particularly ascorbic acid [18] [20], niacinamide [21] and GSH [22] have skin whitening properties.…”