Autologous platelet‐rich plasma versus readymade growth factors in skin rejuvenation: A split face study

Gawdat, Heba I.; Tawdy, Amira El; Hegazy, Rehab A.; Zakaria, Mohga M; Allam, Riham S H M

doi:10.1111/jocd.12341

Cited by 50 publications

(39 citation statements)

References 26 publications

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“…This study exhibited more promising results with the combined therapy of dermaroller and PRP for volunteers with photoaging when compared to the other side treated only with dermaroller ( P = 0.039), or combined with TCA ( P = 0.048). This is in agreement with Gawdat et al . who suggested the use of PRP for skin rejuvenation as an effective and safe tool for correction of aging signs, owing to the significantly higher patient satisfaction, fewer side effects, and more sustainable results.…”

Section: Discussionsupporting

confidence: 91%

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Combining microneedling with other minimally invasive procedures for facial rejuvenation: a split‐face comparative study

2018

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Section: Discussionsupporting

confidence: 91%

“…Autologous PRP creates an instant, long‐lasting volumetric effect with natural looking results and optimal patient satisfaction . It's efficient and safe for skin rejuvenation when compared with ready‐made growth factors …”

Section: Discussionmentioning

confidence: 99%

Combining microneedling with other minimally invasive procedures for facial rejuvenation: a split‐face comparative study

2018

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“…A split‐face trial with 20 Asian females showed that PRP treatment is an effective alternative treatment method for infraorbital skin rejuvenation compared with PPP and normal saline, more safely and more easily applied . And in contrast to the readymade growth factors, autologous PRP also appeared to be safer and more effective for skin rejuvenation . And there are several pointed trials in various aspects of facial rejuvenation.…”

Section: Application Of Prpmentioning

confidence: 61%

Applications and efficacy of platelet‐rich plasma in dermatology: A clinical review

Zhang

Park

Zhou

et al. 2018

J of Cosmetic Dermatology

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The platelet-rich plasma (PRP) has been studied in bone-related applications for accelerating healing, and the proliferation and regeneration of tissue. Now the dermatological indications increase rapidly in recent years. We have reviewed clinical trials, comparative trials, and meta-analysis of PRP on dermatology through key words and reorganized them into facial rejuvenation, hair, scar, vitiligo, and synergistic effect with fractional CO , with a conclusion that PRP has significant improvements in dermatology. But the lack of RCTs and the limit of samples cannot provide sufficient enough evidence for general clinical applications. More RCTs are needed for the increasing demand of new dermatologic therapeutics, and we need adequate samples urgently to make the results more persuasive.

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“…PRF has been widely used in clinical practice to improve the efficacy of cell-assisted lipotransfer (CAL) and wound repair by ASCs, due to its advantages in preventing immunologic rejection, simple production, and few complications. Moreover, plastic surgeons have adopted PRP, a predecessor of PRF, as a rejuvenator to treat aging skin by intradermal injection [8, 34, 35]. …”

Section: Discussionmentioning

confidence: 99%

Precise Intradermal Injection of Nanofat-Derived Stromal Cells Combined with Platelet-Rich Fibrin Improves the Efficacy of Facial Skin Rejuvenation

Liang

Lü

et al. 2018

Cell Physiol Biochem

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Background/Aims: The rejuvenation properties of nanofat grafting have been described in recent years. However, it is not clear whether the clinical efficacy of the procedure is attributable to stem cells or linked to other components of adipose tissue. In this study we isolated nanofat-derived stem cells (NFSCs) to observe their biological characteristics and evaluate the efficacy of precise intradermal injection of nanofat combined with platelet-rich fibrin (PRF) in patients undergoing facial rejuvenation treatment. Methods: Third-passage NFSCs were isolated and cultured using a mechanical emulsification method and their surface CD markers were analyzed by flow cytometry. The adipogenic and osteogenic nature and chondrogenic differentiation capacity of NFSCs were determined using Oil Red O staining, alizarin red staining, and Alcian blue staining, respectively. Paracrine function of NFSCs was evaluated by enzyme-linked immunosorbent assay (ELISA) at 1, 3, 7, 14, and 28 days after establishing the culture. Then, the effects of PRF on NFSC proliferation were assessed in vitro. Finally, we compared the outcome in 103 patients with facial skin aging who underwent both nanofat and intradermal PRF injection (treatment group) and 128 patients who underwent hyaluronic acid (HA) injection treatment (control group). Outcomes in the two groups were compared by assessing pictures taken at the same angle before and after treatment, postoperative recovery, incidence of local absorption and cysts, and skin quality before treatment, and at 1, 12, 24 months after treatment using the VISIA Skin Image Analyzer and a SOFT5.5 skin test instrument. Results: NFSCs expressed CD29, CD44, CD49d, CD73, CD90, and CD105, but did not express CD34, CD45, and CD106. NFSCs also differentiated into adipocytes, osteoblasts, and chondrocytes under appropriate induction conditions. NFSCs released large amounts of growth factors such as VEGF, bFGF, EGF, and others, and growth factor levels increased in a time-dependent manner. At the same time, PRF enhanced proliferation of NFSCs in vitro in a dose-dependent manner, and the growth curves under different concentrations of PRF all showed plateaus 6d after seeding. Facial skin texture was improved to a greater extent after combined injection of nanofat and PRF than after control injection of HA. The nanofat-PRF group had a higher satisfaction rate. Neither treatment caused any complications such as infection, anaphylaxis, or paresthesia during long-term follow-up. Conclusion: NFSCs demonstrate excellent multipotential differentiation and paracrine function, and PRF promotes proliferation of NFSCs during the early stage after seeding. Both nanofat-PRF and HA injection improve facial skin status without serious complications, but the former was associated with greater patient satisfaction, implying that nanofat-PRF injection is a safe, highly effective, and long-lasting method for skin rejuvenation.

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Autologous platelet‐rich plasma versus readymade growth factors in skin rejuvenation: A split face study

Abstract: Platelet-rich plasma is effective and safe for skin rejuvenation, comparable to readymade growth factors with noticeable higher longevity.

Cited by 50 publications

References 26 publications

Combining microneedling with other minimally invasive procedures for facial rejuvenation: a split‐face comparative study

Combining microneedling with other minimally invasive procedures for facial rejuvenation: a split‐face comparative study

Applications and efficacy of platelet‐rich plasma in dermatology: A clinical review

Precise Intradermal Injection of Nanofat-Derived Stromal Cells Combined with Platelet-Rich Fibrin Improves the Efficacy of Facial Skin Rejuvenation

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