Clinical Assessment of a Mesotherapy Formulation for Skin Rejuvenation in Healthy Volunteers

Abstract

Mesotherapy is a mildly invasive procedure involving several subcutaneous drug injections, which are performed simultaneously. The concept is to inject a very small amount of active compounds (hyaluronic acid, vitamins, antioxidants, enzymes, humectants, …) and the aim is to stimulate the biosynthetic capacity of fibroblasts, increase collagen and elastin production and to give active essential molecules for a fibroblasts environment. Numerous studies suggest that the mesotherapy procedure improves skin hydration and mechanical properties; however, some results have not been statistically significant. In this study, we investigated an antiaging treatment as a complementary approach to a non-surgical rejuvenating procedure after 5 sessions of mesotherapy. Our main objective was to assess the improvement of face, neck and neckline skin quality, after intradermal microinjections of NCTF 135HA®. This mixture, manufactured by FILORGA Laboratories, includes a non-cross-linked hyaluronic acid, vitamins, antioxidants, mineral salts and enzymes. A statistically significant decrease in the depth of crow's-feet wrinkles (43.3%) and in pore size (58.5%) was observed. Also, dermatological scores showed a significant decrease, and data suggest that skin tone was improved with a brighter tone. The injected mixture could then have an action on the skin pigmentation process with a photoprotective effect. Evolution of Dermis density was also investigated and an increase of dermal density and thickness were highlighted, showing an improvement of skin firmness with significant increases of dermis thickness (20%) and dermis density (24%), indicating a neocollagen activity.

Employing hyaluronic acid‐based mesotherapy for facial rejuvenation

“…10 Biophysical measurements and colorimetry showed improvement in both superficial and deep skin hydration, erythema, PH of skin, and sebum produc tion. [1][2][3][6][7][8][9]11,12,14 Histological and ultrasound evaluation confirmed clinicopathological and biophysical improvements was confirmed to continue up to 3 months by some studies. [1][2][3][6][7][8][9]11,12,14 In contrast, four studies revealed no significant improvement in clinical or histological features of skin with different compounds of mesococktail.…”

“…[1][2][3][6][7][8][9]11,12,14 Histological and ultrasound evaluation confirmed clinicopathological and biophysical improvements was confirmed to continue up to 3 months by some studies. [1][2][3][6][7][8][9]11,12,14 In contrast, four studies revealed no significant improvement in clinical or histological features of skin with different compounds of mesococktail. Although electron microscopy showed neocollagenesis of smaller caliber collagen fibers, but the result was not statistically significant.…”

“…Treatment sessions for non-cross-linked HA were between 1 and 6 at weekly-to-bimonthly interval, and for cross-linked HA were Fourteen studies used mesotherapy compounds for face rejuvenation with contradictory results. [1][2][3][4][5][6][7][8][9][10][11][12][13][14] Ten studies revealed significant improvement in clinical features, biophysical measurements, and histological and ultrasound evaluation. Results of these studies confirmed efficacy of non-cross-linked HA on fine lines for both static and dynamic rhytids.…”

Evaluation of the Performance and Tolerance of the Combination of an HA-based Filler with Tri-Hyal Technology and a Skin Biorevitalizer on Skin Aging Parameters

“…1 The greatest immediately clinical effects observed after facial biorevitalization are reduction of wrinkles, the improvement of deep hydration, firmness, uniformity, and radiance of the complexion. 2,3 In recent years, dermal fillers that became the material of choice are HA-based fillers for use in soft tissue and dermal correction and mostly replacing collagen fillers. 4,5 Hyaluronic acid is widely used in anti-aging products, either in native form in products to be injected by skin biorevitalization techniques or cross-linked in dermal fillers.…”

Immunotropic effects of mesotherapy used for correction of age-related skin changes

“…В этом плане лидирующие позиции принадлежат инъекционной косметологии. Особое место и популярность мезотерапии в эстетической медицине обусловлены возможностью патогенетического подхода к решению косметических проблем, связанных, прежде всего, со старением кожи [4,7,9]. Старение кожи -постепенный процесс, обусловленный функциональными и структурными изменениями, а возможность противодействия посредством восстановления состояний кожи с помощью биоактивных пептидов заслуживает самый присталь-ный интерес.…”