Hemodialysis induces oxidative stress causing intravascular inflammation, which may cause endothelial dysfunction. We evaluated how hemodialysis-induced changes in blood affect the function of endothelial cells in in vitro culture. Serum samples were collected from 42 uremic patients treated with hemodialysis, one before the start of dialysis and the other one at the end of session. All patients were dialysed with polysulfone dialyzer. Concentrations of the inflammatory molecules carbonyl protein and metabolites of NO synthesis were measured in blood. Additionally, the effect of the serum obtained before and after dialysis on the function of endothelial cells in in vitro culture was studied. Hemodialysis caused increase of monocyte chemoattractant protein (MCP)-1 (+17%), hepatocyte growth factor (+91%), and pentraxin-3 (+30%) concentration in serum. Concentration of carbonyl protein was decreased by 30%. Decrease of blood level of asymmetric dimethylarginine (-25%) and nitrate/nitrites (-62%) was observed. Serum obtained after hemodialysis stimulated proliferation of endothelial cells (+10%) and synthesis of MCP-1(+11%) in these cells. Hemodialysis-induced intravascular inflammation changes the function of endothelial cells, which may lead to acceleration of atherosclerosis.

The COVID-19 pandemic resulted in unprecedented changes in the functioning of the health care system, which were connected with the occurrence of new challenges for both the health care system’s employees and for the patients. The purpose of the present article is to analyze the needs of persons with oncological diseases. Taking into account the multiple aspects of the term health, psychological, social, and existential needs of the patients were analyzed. This article is directed mainly at persons who remain in a direct therapeutic relation with a patient. It is to facilitate recognizing the needs of ill people and to increase sensitivity to the issue of maintaining or improving the well-being of patients which requires paying special attention to their psychological, social, and existential needs during the period of hindered access to the health care system. This systematic review takes advantage of quantitative and qualitative methods of text analysis with phenomenological analysis factored in. The COVID-19 pandemic resulted in the appearance of new problems in the population of oncological patients or it made the existing problems more severe. As a consequence, it made it significantly more difficult to meet their needs on various levels and sometimes it even made it impossible. It seems necessary to determine and introduce strategies to ensure that patients with oncological diseases have access to psychological and spiritual support in the period of the pandemic.

Background: Skin ageing is a physiological process, progressive and irreversible. Hyaluronic acid injection treatments are used to correct the signs of skin ageing. Material and Methods: Hyaluronic acid was implanted in the area of the cheek and the forehead aesthetic units in 57 women, aged 35−55 years. Apart from the clinical observation, self-assessment of the therapeutic results was conducted. The "My skin" questionnaire was used for subjective evaluation of the treatment results. Results: Mean wrinkle score in the pre-menopausal group changed after the treatment, from 3.2±0.6 to 1.1±0.3 and from 3.2±0.6 to 0.8±0.6 for the forehead and the cheek esthetic units, respectively. In the post-menopausal group, the score decreased from 3.8±0.4 to 1.7± 0.7 and from 3.2±0.617 to 0.8± 0.6 for the forehead and the cheek esthetic units, respectively. The changes were age-dependent. Improved appearance of the facial skinhigher satisfaction with skin tone and scentwas reported after hyaluronic acid injections. Higher subjective perception of improvement corresponded to older age, irrespectively of the menopausal status. Correlations between age and the effect of the treatment on maintaining proper skin hydration as well as between improved appearance of the forehead area and feelings of autonomy and well-being were found. Conclusion: Hyaluronic acid injections significantly improved the subjective perception and overall assessment of the scent and appearance of the facial skin.

Background: Vinyasa yoga practice improves body fitness and potentially positively affects practitioners’ well-being and health. Due to the diverse intensity of practice and positions customized to the practitioner’s needs, it can also support cancer patients. Undertaking physical activity that has a potentially positive effect on well-being and health was particularly important during the self-isolation that followed the COVID-19 pandemic. The purpose of this study was to evaluate the impact of three-month mild and moderate intensity vinyasa yoga practice on breast-cancer patients’ stress perception, self-confidence, and sleep quality during COVID-19 induced self-isolation. Methods: Female breast-cancer patients participated in twelve-weeks of online vinyasa practice during the COVID-19 induced self-isolation period. Meetings were held once a week, where 60-min vinyasa yoga sequences were followed by 15 min of relaxation. Patients completed pre- and post-intervention surveys to evaluate changes in the following outcomes: stress perception, self-confidence, and sleep quality. Forty-one female patients enrolled in the Vinyasa course completed the pre-intervention survey, while 13 attended all the meetings and completed the post-intervention survey. Results: The effect of the twelve-week yoga and relaxation practice significantly reduced sleep problems and stress of oncological patients. The participants also declared an improvement in their general well-being and self-acceptance. Conclusion: Dynamic forms of yoga combined with mindfulness techniques can be applied to patients treated for oncological diseases. It contributes to improving their well-being. However, in-depth studies are needed to analyze the complexity of this effect.

IntroductionAccording to the offi cial forecasts the population of people aged 65 and over in the European Union will increase from 87.5 million in 2010 to 152.6 million in 2060. There are also predictions of the number of persons aged 80 and above growing from 23.7 million in 2010 to 62.4 million in 2060 [1]. Designing and implementing measures aimed at improving the quality of such extended life is one of the challenges facing medicine today.Quality of life (QoL) is a multi-dimensional and interdisciplinary term. Various sciences make attempts to conceptualise this term -above all medicine and psychology, but also sociology, pedagogy and economics. Hence the multitude and variety of defi nitions highlighting different aspects of human functioning and their importance in the process of formulating a subjective assessment of one's own life. Assessment of the QoL of the elderly is very diffi cult because the elderly are not a homogenous social group [2], and old ABSTRACT Introduction. Due to the prolonged average life span and constantly increasing number of the elderly, research of this population's quality of life (QoL) is being conducted to assess the spheres requiring improvement. Aim. To assess and compare the life quality in different domains between residents of nursing homes (NH) and patients of the Psychogeriatric Day Ward (PDW). Material and Methods. The study encompassed 68 PDW patients and 62 NH residents. The WHOQOL-BREF questionnaire and a structured interview concerning diseases, different forms of support and activities preferred were used. Results. Women predominated among the subjects (83%). The elderly aged 75-90 constituted the majority (64.62%). The average assessment of QoL in the whole group amounted to 3.6 points. No signifi cant differences in the assessment of QoL satisfaction and one's own health satisfaction were observed between PDW patients and NH residents. The participants of both groups assessed the highest QoL in the environment domain and the lowest in the social relationships domain. A relationship between higher QoL in the physical health domain and participation in social forms of spending free time was observed. Relationships between QoL in particular domains and age, marital status and length of stay in NH were found. Conclusions. Elderly people's QoL, similarly to their satisfaction with health, were on an average level regardless of the institutional care. The QoL remains in a signifi cant relationship with health. The changing needs of the elderly should be the basis for creating an individual plan of professional support.