Anti-TMV Activity of Malformin A1,  a Cyclic Penta-Peptide Produced by an Endophytic Fungus  Aspergillus tubingensis FJBJ11

Tan, Qing-Wei; Gao, Fangluan; Wang, Furong; Chen, Qi-Jian

doi:10.3390/ijms16035750

Cited by 31 publications

(16 citation statements)

References 30 publications

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“…Seven malformins ( 114 – 120 ) were isolated from a few Aspergillus species [ 88 , 89 , 90 , 91 ]. Malformin A1 ( 114 ) from Aspergillus niger and Aspergillus tubingensis showed malformation activity in the corn root, and cytotoxic activity, and anti-TMV activity [ 89 , 90 , 92 , 93 ]. Malformin C ( 119 ) from Aspergillus niger had potent cell growth inhibition activity [ 94 ], but its therapeutic index was too low to be an anti-cancer drug [ 95 ].…”

Section: Cyclic Pentapeptidesmentioning

confidence: 99%

Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Wang

Lin

et al. 2017

Molecules

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Cyclic peptides are cyclic compounds formed mainly by the amide bonds between either proteinogenic or non-proteinogenic amino acids. This review highlights the occurrence, structures and biological activities of fungal cyclic peptides (excluding cyclodipeptides, and peptides containing ester bonds in the core ring) reported until August 2017. About 293 cyclic peptides belonging to the groups of cyclic tri-, tetra-, penta-, hexa-, hepta-, octa-, nona-, deca-, undeca-, dodeca-, tetradeca-, and octadecapeptides as well as cyclic peptides containing ether bonds in the core ring have been isolated from fungi. They were mainly isolated from the genera Aspergillus, Penicillium, Fusarium, Acremonium and Amanita. Some of them were screened to have antimicrobial, antiviral, cytotoxic, phytotoxic, insecticidal, nematicidal, immunosuppressive and enzyme-inhibitory activities to show their potential applications. Some fungal cyclic peptides such as the echinocandins, pneumocandins and cyclosporin A have been developed as pharmaceuticals.

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Section: Cyclic Pentapeptidesmentioning

confidence: 99%

Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Wang

Lin

et al. 2017

Molecules

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“…The fungus A. tubingensis has been reported to produce xylanase, [18] the indole diterpenes dihydrotubingensin A and B, [19] the cyclic penta-peptide malformin A1, [20] naphtho-g-pyrones such as asperpyrone A and D, aurasperone A and E, rubasperone A-C and other metabolites. [21,22] In our previous study, we found that the marine-derived fungus A. tubingensis SZX-6 showed antibacterial activities against the aquatic pathogen V. anguillarum.…”

Section: Resultsmentioning

confidence: 99%

Bioassay-guided fractionation and identification of active substances from the fungusAspergillus tubingensisagainstVibrio anguillarum

Guo

Zhu

2016

Biotechnology & Biotechnological Equipment

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The aim of this study was to perform bioassay-guided fractionation and identification of active substances against the aquatic pathogen Vibrio anguillarum from the fungus Aspergillus tubingensis SZX-6 associated with the crab Portunus trituberculatus. Based on the antibacterial activity against V. anguillarum, three compounds were isolated and purified from the culture broth of strain SZX-6 by sequential column chromatography over silica gel, Sephadex LH-20 and RP-18. The isolated compounds were identified on the basis of extensive spectroscopic data analysis. They were methyl 6-acetyl-5,7,8-trihydroxy-4-methoxy-2-naphthoate (1), daidzein (2) and genistein (3). Compound 1 showed moderate antibacterial activity against V. anguillarum (minimum inhibitory concentration 0.063 mg/mL). The obtained results could serve as a basis for further research towards design of active antibacterial agents against aquatic pathogens.

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“…Plant-associated microorganisms are known to produce a variety of metabolites with novel structures and interesting biological activities (4)(5)(6)(7)(8). MA1 isolated from the fungus A. niger has been found to possess a range of bioactive properties, which includes enhancing fibrinolytic activity, and acting as an antibacterial/viral/fungal agent (13)(14)(15)(16)(17)(18). Furthermore, MA1 exhibits a strong cytotoxic effect against various human cancer cell lines (9,(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

“…Malformin A1 (MA1) is a bicyclic pentapeptide containing five amino acids: L-isoleucine, L-valine, D-leucine, and two D-cysteines (12). MA1 is the most well-studied out of the malformin subtypes, and its various biological activities have been reported previously, including causing malformations in plants, having some antibacterial effects (13)(14)(15), enhancing cellular fibrinolytic activity (16 -18), preventing IL-1-induced procoagulant reaction (19,20), and inhibiting the cell cycle at G2 checkpoint followed by DNA damage (21,22). Additionally, the anticancer activity of MA1 has been reported in various human cancer cells including colorectal cancer (9,22-24).…”

Section: Introductionmentioning

confidence: 99%

Malformin A1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway

Park

et al. 2017

International Journal of Oncology

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Malformin A1 (MA1), a cyclic pentapeptide isolated from Aspergillus niger, has been found to possess a range of bioactive properties including antibacterial activity. However, it is unclear whether MA1 exerts an anticancer effect or not. In this study, we conducted in vitro experiments to investigate its anticancer properties in human colorectal cancer cells. The effect of MA1 on human colorectal cancer cells, SW480 and DKO1, was examined by the WST-1 cell viability assay, inverted microscopy, 5-bromo-2-deoxyuridine (BrdU) incorporation, flow cytometry, DNA fragmentation, wound healing, Transwell assays, and western blotting. MA1 treatment showed potent cytotoxic activities on human colorectal cancer cells. MA1 treatment induced apoptosis by activating the poly(ADP-ribose) polymerase (PARP), caspase‑3, -7, and -9. MA1 treatment led to the increase in p53 upregulated modulator of apoptosis (PUMA) and the decrease in X-linked inhibitor of apoptosis protein (XIAP) and Survivin. In addition, MA1 treatment induced cell cycle arrest in the sub-G1 phase. The pan-caspase inhibitor, Z‑VAD‑FMK, attenuated these MA1-induced apoptotic effects on human colorectal cancer cells. Moreover, MA1 treatment suppressed tumor cell migration and invasion. The phosphorylation level of p38 was upregulated by MA1 treatment, and the inhibitor of p38, SB203580, attenuated the MA1-induced p38 phosphorylation as well as caspase‑3 and PARP activation. These results indicate that MA1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through the stimulation of the p38 signaling pathway.

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Anti-TMV Activity of Malformin A1, a Cyclic Penta-Peptide Produced by an Endophytic Fungus Aspergillus tubingensis FJBJ11

Cited by 31 publications

References 30 publications

Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Bioassay-guided fractionation and identification of active substances from the fungusAspergillus tubingensisagainstVibrio anguillarum

Malformin A1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway

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