Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Wang, Xiaohan; Lin, Maojuan; Xu, Dan; Lai, Daowan; Zhou, Ligang

doi:10.3390/molecules22122069

Cited by 67 publications

(52 citation statements)

References 227 publications

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“…Cyclopeptide alkaloids are mainly constructed from proteinogenic or nonproteinogenic amino acids that are joined together by amide bonds [54]. These alkaloids can be widely synthesized by both terrestrial and marine organisms.…”

Section: Cyclopeptide Alkaloidsmentioning

confidence: 99%

Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

Yuan

et al. 2020

Marine Drugs

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Nitrogen heterocycles have drawn considerable attention due to of their significant biological activities. The marine fungi residing in extreme environments are among the richest sources of these basic nitrogen-containing secondary metabolites. As one of the most well-known universal groups of filamentous fungi, marine-derived Aspergillus species produce a large number of structurally unique heterocyclic alkaloids. This review attempts to provide a comprehensive summary of the structural diversity and biological activities of heterocyclic alkaloids that are produced by marine-derived Aspergillus species. Herein, a total of 130 such structures that were reported from the beginning of 2014 through the end of 2018 are included, and 75 references are cited in this review, which will benefit future drug development and innovation.

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Section: Cyclopeptide Alkaloidsmentioning

confidence: 99%

Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

Yuan

et al. 2020

Marine Drugs

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“…Incorporation of the cyanobacterium Scytomena ocellatum, with added elicitors (e.g., fungal wall polysaccharides), led to increasing the production of tolytoxin [120]. The marine fungus Phomopsis asparagi cultured in the presence of the spongal product jasplakinolide, which redirected its synthetic pathway to yield chaetoglobosins.…”

Section: Conclusion and Future Prospectivementioning

confidence: 99%

Nidulantes of Aspergillus (Formerly Emericella): A Treasure Trove of Chemical Diversity and Biological Activities

et al. 2020

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The genus Emericella (Ascomycota) includes more than thirty species with worldwide distribution across many ecosystems. It is considered a rich source of diverse metabolites. The published classes of natural compounds that are discussed here are organized according to the following biosynthetic pathways: polyketides (azaphilones, cyclopentenone pigments, dicyanides, furan derivatives, phenolic ethers, and xanthones and anthraquinones); shikimate derivatives (bicoumarins); mevalonate derivatives (meroterpenes, sesquiterpenes, sesterterpenes and steroids) and amino acids derivatives (alkaloids (indole-derivatives, isoindolones, and piperazine) and peptides (depsipeptides)). These metabolites produce the wide array of biological effects associated with Emericella, including antioxidant, antiproliferative, antimalarial, antiviral, antibacterial, antioxidant, antihypertensive, anti-inflammatory, antifungal and kinase inhibitors. Careful and extensive study of the diversity and distribution of metabolites produced by the genus Emericella (either marine or terrestrial) revealed that, no matter the source of the fungus, the composition of the culture medium effectively controls the metabolites produced. The topic of this review is the diversity of metabolites that have been identified from Emericella, along with the contextual information on either their biological or geographic sources. This review presents 236 natural compounds, which were reported from marine and terrestrial Emericella. Amongst the reported compounds, only 70.2% were biologically assayed for their effects, including antimicrobial or cytotoxicity. This implies the need for substantial investigation of alternative activities. This review includes a full discussion of compound structures and disease management, based on materials published from 1982 through December 2019.

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“…Marine fungi are known to be rich sources of biologically active compounds for medicinal and agricultural applications [ 1 , 2 , 3 , 4 ]. Indole alkaloids have attracted a great deal of attention due to their diversified structures and potent biological activities, such as cytotoxicity, anti-feedant, and anti-microbial activities [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012

et al. 2018

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Two new alkaloids, fumigatosides E (1) and F (2), and a new natural product, 3, 7-diketo-cephalosporin P1 (6) along with five known compounds (3–5, 7, 8) were isolated from deep-sea derived fungal Aspergillus fumigatus SCSIO 41012. Their structures were determined by extensive spectroscopic data analysis, including 1D, 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS), and comparison between the calculated and experimental electronic circular dichroism (ECD) spectra. In addition, all compounds were tested for antibacterial and antifungal inhibitory activities. Compound 1 showed significant antifungal activity against Fusarium oxysporum f. sp. momordicae with MIC at 1.56 µg/mL. Compound 4 exhibited significant higher activity against S. aureus (16,339 and 29,213) with MIC values of 1.56 and 0.78 µg/mL, respectively, and compound 2 exhibited significant activity against A. baumanii ATCC 19606 with a MIC value of 6.25 µg/mL.

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Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides

Cited by 67 publications

References 227 publications

Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

Nidulantes of Aspergillus (Formerly Emericella): A Treasure Trove of Chemical Diversity and Biological Activities

Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012

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