ANTI-OXIDANT AND ANTI-DIABETIC ACTIVITIES OF ETHANOLIC EXTRACT OF Primula denticulata FLOWERS

Bhatt, Hemlata; Saklani, Sarla; Upadhayay, Kumud

doi:10.14499/indonesianjpharm27iss2pp74

Cited by 28 publications

(25 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The use of oral drugs does not always have a positive impact on DM treatment. Oral medication use often has side effects that lead to other symptoms causing complications (Fadillah 2014;Fatimah 2015).…”

Section: Introductionmentioning

confidence: 99%

Aktivitas In Vitro Penurun Gula Darah dari Ekstrak Buah Parijoto (Medinilla speciosa B.)

Vifta¹,

Wilantika²,

Advistasari³

2020

bul. littro

View full text Add to dashboard Cite

Diabetes mellitus is one of the highest causes of death in the world, with symptoms of increased blood glucose levels (hyperglycemia). One of the efforts made as a treatment and prevention of DM is through complementary therapy using natural ingredients. Parijoto fruit (<em>Medinilla speciosa</em>) contains flavonoid compounds potential to reduce glucose levels. The study aimed to analyze the effectiveness of ethanol extracts and its fractions of parijoto fruit (EEBP) to decrease glucose levels in vitro. The study was conducted at the Ngudi Waluyo University Laboratory in April to August 2018. Identification and screening of flavonoid compounds from ethanol extracts and its fractions of parijoto fruit were performed qualitatively and by thin-layer chromatography (TLC). <em>In vitro</em> testing for antidiabetic activity of EEBP was performed with non-enzymatic reaction by Nelson Somogyi method (ethanol extract and its fractions). Experiment was arranged in a randomized block design, with 12 treatments and three replications. The concentrations of parijoto fruit tested were 10 ppm, 20 ppm, 30 ppm, 40 ppm, 50 ppm, and 60 ppm. The results of qualitative identification and TLC showed that the ethanol extract and its fraction of EEBP contained flavonoid compounds. At a concentration of 30 ppm, EEBP was able to reduce glucose levels by 42.43 %, while the ethanol fraction decreased glucose levels by 83.38 %. The results showed parijoto fruit ethanol extract and its fractions were sources of antidiabetic. Hence its pharmacologically effect was necessary to be further studied.

show abstract

Section: Introductionmentioning

confidence: 99%

Aktivitas In Vitro Penurun Gula Darah dari Ekstrak Buah Parijoto (Medinilla speciosa B.)

Vifta¹,

Wilantika²,

Advistasari³

2020

bul. littro

View full text Add to dashboard Cite

show abstract

“…Ethanolic extract of Рrimula denticulata Smith shows wound healing, antioxidant, antibacterial, antidiabetic activities (Singh et al 2014a;Bhatt et al 2016) and plays an important role in the intonation of oxidative stress (Aslam et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Determination of the optimum extraction regime of reducing compounds and flavonoids of Primula denticulata Smith leaves by a dispersion analysis

Budniak¹,

Vasenda²,

Marchyshyn³

et al. 2020

PHAR

View full text Add to dashboard Cite

Herbal medicines are widely used in the complex treatment of various diseases. Therefore, theoretical and practical interest is the in-depth study of drumstick primrose (Primula denticulata Smith). The study aimed to determine the optimal extraction mode of flavonoids and reducing compounds of drumstick primrose leaves. The concentration of ethanol, the ratio of raw materials and extractant, and extraction method were studied by dispersion analysis. This allowed reducing the number of experiments from 64 to 16. To obtain the alcohol extract of drumstick primrose leaves with the highest content of reducing compounds and flavonoids, found that maceration is the optimal method of extraction, the ratio of raw materials to extractant should be 1 to 5 and 40% ethanol is the most appropriate extractant.

show abstract

“…Antioxidant activity describes the ability of an antioxidant compound to neutralise free radicals so that it can delay, slow down, and prevent the occurrence of free radical antioxidation reactions in lipid oxidation (Shahidi & Zhong, 2015). The mechanism of reducing blood glucose levels is carried out by stimulating the secretion of the insulin hormone, increasing glucose uptake from blood to tissues, oxidating glucose, and activating glycogen synthesis in the liver and adipose tissue (Lee & Jun, 2014;Bhatt et al, 2016). Increased cumulative action of all the antioxidants present in plasma and body fluids in vivo will be able to balance oxidants and antioxidants.…”

Section: There Is a Correlation Between The Escalation Of Total Antioxidant Capacity Of Plasma And The Decline Of Blood Glucose Levelmentioning

confidence: 99%

Correlation between the antioxidant capacity of plasma and blood glucose level

Nurinda¹,

Emelda²,

Kusumawardani³

2021

Pharm Educ

View full text Add to dashboard Cite

Introduction: Oxidative stress on tissues can cause diseases such as diabetes mellitus (DM). Aim: This study aimed to pharmacologically evaluate the decrease in blood glucose levels and its relationship with the total antioxidant capacity of the blood compared to glibenclamide. Method: An experimental study with completely randomised designs was carried out. Rats were induced with streptozotosin followed by ethanolic extract for ten days. Results: The One-Way Anova test, showed that the increase of the total antioxidant capacity of plasma treated with ethanolic extract of Tinospora cordifolia and Curcuma zanthorrhiza was comparable in the same amount to glibenclamide (p=0.345), (p=0.289). There was a relationship between total blood antioxidant capacity and blood glucose levels, this linear association was expressed with the following mathematical equation: y = 20,253 - 2,946x. Conclusion: The antioxidant content of Tinospora cordifolia, Curcuma zanthorrhiza, and Cinnamomum verum has the potential to control blood glucose in diabetes mellitus.

show abstract

ANTI-OXIDANT AND ANTI-DIABETIC ACTIVITIES OF ETHANOLIC EXTRACT OF Primula denticulata FLOWERS

Cited by 28 publications

References 9 publications

Aktivitas In Vitro Penurun Gula Darah dari Ekstrak Buah Parijoto (Medinilla speciosa B.)

Aktivitas In Vitro Penurun Gula Darah dari Ekstrak Buah Parijoto (Medinilla speciosa B.)

Determination of the optimum extraction regime of reducing compounds and flavonoids of Primula denticulata Smith leaves by a dispersion analysis

Correlation between the antioxidant capacity of plasma and blood glucose level

Contact Info

Product

Resources

About