The present investigation was carried out to focus on the anti-oxidant and anti-diabetic effect of ethanolic extract of flowers of Primula denticulata by DPPH, ferrous chelating, reducing power assay and streptozotocin induced diabetes respectively. Dose selection was made on the basis of acute oral toxicity study (100mg/kg, 200mg/kg, 400mg/kg bodyweight) as per OECD guidelines 423. The blood glucose levels were measured by using blood glucose measuring strips based on glucose-oxidase method. The extract showed significant anti-oxidant and anti-diabetic activity when compared with standard drug.

Objective: Hydromethanolic extract of the bark of Zanthoxylum armatum (HMZA) was evaluated for its antidiabetic and antioxidant activity in streptozotocin-induced diabetic rats. Materials and Methods: HMZA was evaluated in normal and diabetic rats. Diabetes was induced by streptozotocin (60 mg/kg i.p.). Normal and diabetic rats were divided into different groups and orally administered with HMZA (200 and 400 mg/kg) and glibenclamide (5 mg/kg) for 21 days. Blood samples were collected from overnight-fasted rats on at 7, 14 and 21 days of treatment and analysed for blood glucose level and lipid profile. On day 21, rats were sacrificed and liver and kidney tissues were excised to measure their antioxidant status. Results: Oral administration of HMZA for 21 days (200 and 400 mg/kg) resulted in significant reduction in blood glucose, total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein and significant increase in high density lipoprotein and body weight of streptozotocin diabetic rats. In addition to that, significant decrease in lipid peroxidation and increase in catalase, superoxide dismutase and reduced glutathione were observed in streptozotocin diabetic rats. Conclusion: From the present study, it is evident that, the bark of Z. armatum possesses significant antidiabetic and antioxidant effect on diabetic rats and suggests that the plant may have therapeutic value in diabetes and related complications.

Objective: To evaluate the phytochemical, physicochemical, antimicrobial and in-vitro antioxidant activity of Clamentis montana (Family: Rananculaceae).Methods: The extracts were evaluated for antibacterial activity against S. aureus, B. subtilis, E. coli, P. aeruginosa by cup plate method. In-vitro antioxidant activity was done by DPPH, ferrous chelating and reducing power assay method. The physicochemical parameter like a loss on drying, total ash value, foreign matter, etc. was evaluated by standard protocol.Results: The extract showed significant antibacterial activity against all test strains when compared with standard drugs amoxicillin. The extract showed significant antioxidant activity by DPPH method, reducing power assay and ferrous chelating method.Conclusion: The extract showed a dose-dependent significant antibacterial and antioxidant activity.