Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium

Hernayanti, Hernayanti; Lestari, Sri; Saryono, Saryono; Lestari, Puji

doi:10.20884/1.jm.2021.16.3.775

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…Hernayanti et al ( 2021) [107] demonstrated that the administration of C. asiatica extract (100-400 mg/kg) for 21 days was able to ameliorate the Cd-induced hepato-inflammation, by decreasing Cd, TNF-α and COx2 levels and increasing GST and GSH ones. Moreover, Flora et al (2007) [108] suggested that the treatment with an aqueous extract of C. asiatica (100-500 mg/kg) for 5 days allowed for the reversal of As-induced oxidative stress in rats, even though it did not possess chelating property since the levels in the blood and soft tissues remained unvaried.…”

Section: Plant and Herbal Extracts In The Management Of Heavy Metal-i...mentioning

confidence: 99%

Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

Ceramella,

De Maio,

Basile

et al. 2024

Foods

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Heavy metals (HMs) are natural elements present in the Earth’s crust, characterised by a high atomic mass and a density more than five times higher than water. Despite their origin from natural sources, extensive usage and processing of raw materials and their presence as silent poisons in our daily products and diets have drastically altered their biochemical balance, making them a threat to the environment and human health. Particularly, the food chain polluted with toxic metals represents a crucial route of human exposure. Therefore, the impact of HMs on human health has become a matter of concern because of the severe chronic effects induced by their excessive levels in the human body. Chelation therapy is an approved valid treatment for HM poisoning; however, despite the efficacy demonstrated by chelating agents, various dramatic side effects may occur. Numerous data demonstrate that dietary components and phytoantioxidants play a significant role in preventing or reducing the damage induced by HMs. This review summarises the role of various phytochemicals, plant and herbal extracts or probiotics in promoting human health by mitigating the toxic effects of different HMs.

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Section: Plant and Herbal Extracts In The Management Of Heavy Metal-i...mentioning

confidence: 99%

Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

Ceramella,

De Maio,

Basile

et al. 2024

Foods

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“…Chronic Cd exposure stimulates lung tissue and is triggered oxidative stress through suppression of antioxidative enzymes 29 . The content of Cd in blood of rat was significant increased after incubation with CdSO 4 , but decreased the levels of endogenous antioxidant such as glutathione (GSH) and glutathione‐S transferase (GST) 30 . Razzuoli et al found that Cd could promote the expression of pro‐inflammatory cytokines in porcine epithelial cells, such as interleukin‐6 (IL‐6), IL‐8, and IL‐18 and transcription factors, such as NF‐κB, MYD88, and NF‐κB1 31 .…”

Section: Introductionmentioning

confidence: 99%

“…29 The content of Cd in blood of rat was significant increased after incubation with CdSO 4 , but decreased the levels of endogenous antioxidant such as glutathione (GSH) and glutathione-S transferase (GST). 30 Razzuoli et al found that Cd could promote the expression of proinflammatory cytokines in porcine epithelial cells, such as interleukin-6 (IL-6), IL-8, and IL-18 and transcription factors, such as NF-κB, MYD88, and NF-κB1. 31 In addition, metformin, a activator for AMPK, alleviates Cd-stimulated degeneration of spiral ganglion neuron by restoring impaired autophagy flux, attenuating Cd-induced apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Polystyrene exacerbates cadmium‐induced mitochondrial damage to lung by blocking autophagy in mice

Tong

Guo

et al. 2023

Environmental Toxicology

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Cadmium (Cd) is an environmental heavy metal, and its accumulation is harmful to animal and human health. The cytotoxicity of Cd includes oxidative stress, apoptosis, and mitochondrial histopathological changes. Furthermore, polystyrene (PS) is a kind of microplastic piece derived from biotic and abiotic weathering courses, and has toxicity in various aspects. However, the potential mechanism of action of Cd co-treated with PS is still poorly unclear. The objective of this study was to investigate the effects of PS on Cd-induced histopathological injury of mitochondria in the lung of mice. In this study, the results have showed that Cd could induce the activity of oxidative enzymes of the lung cells in mice, increasing the content of partial microelement and the phosphorylation of inflammatory factor NF-κB p65. Cd further destroys the integrity of mitochondria by increasing the expression of apoptotic protein and blocking the autophagy. In addition, PS solely group aggravated the lung damage in mice, especially mitochondrial toxicity, and played a synergistic effect with Cd in lung injury. However, how PS can augment mitochondrial damage and synergism with Cd in lung of mice requiring further exploration. Therefore, PS was able to exacerbate Cd-induced mitochondrial damage to the lung in mice by blocking autophagy, and was associated with the apoptosis.

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“…Drugs and foods are the main sources of free radicals in the human body. Foods polluted with heavy metals frequently cause health problems ( 1 ). Oxidant chemicals from free radicals cause cell damage, weaken immunity, and change cell characteristics.…”

Section: Introductionmentioning

confidence: 99%

Black solo garlic protects hepatic and renal cell function in streptozotocin-induced rats

et al. 2022

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Black solo garlic (BSG) has been evaluated for its ability to reduce free radicals; however, the safety test on kidney and liver function has not been evaluated. This study aimed to examine the effect of brewed BSG on the liver (total protein, albumin, glutathione S-transferase/GST) and kidney (urea, creatinine, and β2-microglobulin) function in streptozotocin (STZ)-induced white rats. The experimental animals were randomly divided into six groups, each including five animals. The groups consist of the normal control group, the STZ-induced control group, the BSG treatment group with doses 6.5, 13.5, and 26 g/kg body weight, and metformin positive control. After STZ induction, the serum levels of GST, total protein, and albumin are decreased. After treatment with BSG, the serum level of GST, total protein, and albumin increased significantly (p < 0.05). The levels of urea, creatinine, and β2-microglobulin increased after STZ induction. After treatment of BSG, levels of urea, creatinine, and β2-microglobulin are decreased significantly (p < 0.05). These results suggest that BSG use is safe for the liver and kidneys of STZ-induced rats.

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Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium

Cited by 5 publications

References 28 publications

Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

Polystyrene exacerbates cadmium‐induced mitochondrial damage to lung by blocking autophagy in mice

Black solo garlic protects hepatic and renal cell function in streptozotocin-induced rats

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