Anti-inflammatory and antioxidant properties of hydroalcoholic crude extract from Casearia sylvestris Sw. (Salicaceae)

Albano, Micheline N.; Silveira, MÃ¡rcia R. da; Danielski, Lucinéia Gainski; Florentino, Drielly; Petronilho, FabrÃ­cia; Piovezan, Anna Paula

doi:10.1016/j.jep.2013.03.049

Cited by 45 publications

(30 citation statements)

References 20 publications

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“…It indicates that this phytotherapic increased the inflammatory response in the first stages of healing with subsequent reduction, highlighting its important self-control of inflammation. C. sylvestris has shown antioxidant and anti-inflammatory effects in experimental models in rats, suggesting that their constituents favor the reduction of cell migration and the activation of acute inflammation [18]. TGF-β1 has a proinflammatory action, released by platelets after the injury, which initiate the inflammatory phase of healing [44].…”

Section: Sylvestris and The Inflammatory Processmentioning

confidence: 99%

“…Such results corroborate with the studies of Baskaran et al [49] in rats with burns that observed that MPO levels up to the 7th day after injury reflected a continuous recruitment of neutrophils through the release of inflammatory mediators from the injured tissue. It was observed that C. sylvestris reduced the late inflammatory response due to its ability to inhibit cell migration and the enzymatic activity of MPO [18]. Neutrophils also favor the recruitment of macrophages to the injury site, which are present in all stages of healing, making phagocytosis of dead cells, exogenous particles (tissue debridement) and stimulating the synthesis of cytokines and chemokines [50].…”

Section: Sylvestris and The Inflammatory Processmentioning

confidence: 99%

“…Among the varieties of medicinal plants suggested for tissue repair, Casearia sylvestris Swartz (Salicaceae), also known as "guaçatonga", native in Mexico, Central America and South America, has ecological, pharmacological, and commercial importance [16]. The species is popularly used in the Brazilian herbal medicine due to its anti-inflammatory, antiviral drugs, antirheumatic, antiophidical [17,18] in the wound healing and gastritis [19]. Most of its pharmacological properties are attributed to clerodic diterpenes present in different parts of the plant, such as casearins, casearvestrins and caseargrevins [20].…”

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confidence: 99%

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Casearia sylvestris Improved Cutaneous Burn Repair in Diabetic Rats

Martelli¹,

Theodoro²,

Gaspi³

et al. 2018

JPP

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Objectives: The burn repair associated with diabetes complications showed considerable changes in the healing process and the development of alternative therapies to favor the repair is important. This study investigated the efficacy of the Casearia sylvestris in the burn repair in diabetic and non-diabetic rats. Methods: The animals were divided into four groups (n = 20): (C) non-diabetics treated with carbopol gel; (G) non-diabetic treated with C. sylvestris extract in carbopol gel; (DM-C) diabetics treated with carbopol gel; (DM-G) diabetics treated with C. sylvestris extract in carbopol gel. Burn was induced using a metal plate (2 cm diameter/120 °C/20 sec). Samples were collected on the 3rd, 7th, 14th and 21st days after the injury for histomorphometric analysis (inflammatory infiltrate, fibroblasts, blood vessels and collagen), MPO (Myeloperoxidase) and NAG (N-Acetilglicosaminidase) dosage, hydroxyproline, glycosaminoglycans, TGF-β1, VEGF, collagen I and III. Key findings: C. sylvestris decreased the inflammatory process during the experimental period in diabetic and non-diabetic animals which has been demonstrated by MPO, NAG quantification, and TGF-β1 expression. C. sylvestris also increased blood vessels and decreased VEGF expression during the studied period in non-diabetic animals. Fibroplasia and collagenase were increased in all experimental periods in the DM-G group by means of de hydroxyproline quantification, collagen I, collagen III and glycosaminoglycans. Conclusions: C. sylvestris application can modulate favorably the time of inflammation and collagenous process in the repair of burn injuries in diabetic rats.

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Section: Sylvestris and The Inflammatory Processmentioning

confidence: 99%

Section: Sylvestris and The Inflammatory Processmentioning

confidence: 99%

mentioning

confidence: 99%

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Casearia sylvestris Improved Cutaneous Burn Repair in Diabetic Rats

Martelli¹,

Theodoro²,

Gaspi³

et al. 2018

JPP

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“…Extract was obtained from leaves of the plant collected at the botanical Horto at the campus of University Southern Santa Catarina (UNISUL), in the municipality of Tubarão, Santa Catarina, Brazil (latitude 28º28'00" south and longitude 49º00'25" west) and prepared as previously described (Albano et al, 2013) and the plant was identified by direct comparison with a voucher specimen (SRS-174) deposited at the herbarium Laelia Purpurata (SRS) at this university. Concentrated HCE of Casearia sylvestris was then stored in a desiccator until the moment of use.…”

Section: Preparation and Characterization Of The Hydroalcoholic Crudementioning

confidence: 99%

“…Antinociceptive actions were evident in animal models of nociceptive, inflammatory and immune mediated pain (De Mattos et al, 2007); furthermore, the HCE-CS was also endowed with anti-inflammatory properties in the model of carrageenan-paw edema in mice, as well as in pleurisy model in rats reducing neutrophil recruitment and nitrite/nitrate production in pleural exsudate (Albano et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways

Piovezan

Batisti

Benevides

et al. 2017

Journal of Ethnopharmacology

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Ethnopharmacological relevanceCasearia sylvestris Sw. is widely used in popular medicine to treat conditions associated with pain. Aim of the studyThe present study investigated the influence of hydroalcoholic crude extract of Casearia sylvestris (HCE-CS) and contribution of pro-resolving mediators on mechanical hyperalgesia in a mouse model of chronic post-ischemia pain (CPIP). Methods and resultsMale Swiss mice were subjected to ischemia of the right hind paw (3 h ConclusionThese results reveal significant antihyperalgesic effect of HCE-CS on CPIP, mediated at least in part, by the pathway of resolution of inflammation centred on the axis modulated by ALX/FPR2.

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Identification of flavonoid‐3‐O‐glycosides from leaves of Casearia arborea (Salicaceae) by UHPLC‐DAD‐ESI‐HRMS/MS combined with molecular networking and NMR

Santos

Soares

Medeiros

et al. 2021

Phytochemical Analysis

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Introduction Casearia is an essential source of cytotoxic highly oxidised clerodane diterpenes, in addition to phenolics, flavonoids, and glycoside derivatives. Here we identify flavonoid‐3‐O‐glycoside derivatives in the ethyl acetate (EtOAc) fraction of the methanolic extract from leaves C. arborea leaves. Objective To characterise the EtOAc phase from the methanolic extract of C. arborea leaves using ultra‐high‐performance liquid chromatography diode array detector high‐resolution tandem mass spectrometry (UHPLC‐DAD‐HRMS/MS) and molecular networking‐based dereplication. Methodology We identified compounds not annotated in the GNPS platform by co‐injection of standards in HPLC‐DAD or by isolation and characterisation of the metabolites using nuclear magnetic resonance (NMR) spectroscopy. A workflow on the GNPS platform aided the organisation of spectral data and dereplication by annotations. We subjected the EtOAc phase to HPLC‐DAD analysis using standard compound co‐injection to corroborate the GNPS annotations. We isolated unidentified compounds with semi‐preparative HPLC‐DAD for structural identification using NMR. Results We annotated a molecular family of flavonoid‐3‐O‐glycosides in the molecular networking created using the GNPS platform. These included avicularin, cacticin, isoquercitrin, quercitrin, rutin, and a quercetin‐3‐O‐pentoside cluster. We confirmed the annotations with standard compounds using HPLC‐DAD co‐injection analysis, besides identifying quercetin‐3‐O‐robinobioside and kaempferol. We isolated three flavonoid‐3‐O‐pentosides and characterised them using one‐ and two‐dimensional NMR; we identified them as reynoutrin, guaijaverin, and avicularin. Conclusion This work describes the isolation of kaempferol and nine known flavonoid‐3‐O‐glycosides from the polar fraction of the methanolic extract (EtOAc) from C. arborea leaves using molecular networking to guide the chromatographic procedures. We identified eight compounds for the first time in Casearia that amplify and reinforce the genus' chemotaxonomy with the presence of glycosylated flavonoids.

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Anti-inflammatory and antioxidant properties of hydroalcoholic crude extract from Casearia sylvestris Sw. (Salicaceae)

Cited by 45 publications

References 20 publications

Casearia sylvestris Improved Cutaneous Burn Repair in Diabetic Rats

Casearia sylvestris Improved Cutaneous Burn Repair in Diabetic Rats

Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways

Identification of flavonoid‐3‐O‐glycosides from leaves of Casearia arborea (Salicaceae) by UHPLC‐DAD‐ESI‐HRMS/MS combined with molecular networking and NMR

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