Anti-inflammatory and antioxidant activities of Moringa peregrina Seeds

Abstract

Access Free Rad. Antiox. www.antiox.org of deteriorative changes in the biological systems leading to cell inactivation. [1] Many antioxidant enzymes and compounds present in the cell, mitigate the oxidative stress due to free radicals, by dismutating these free radicals species or by converting these radicals into a less effective forms. [2] Antioxidant supplements or antioxidant-rich food are used to help the human body reduce oxidative damage from free radicals and active oxygen species. [3] Other synthetic antioxidants such as butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA) and trolox are widely used as antioxidants in the pharmaceutical and food industry. However, they have been shown to have toxic and/or mutagenic effects. [2] Because of their toxicity, the development and isolation of natural antioxidants IntroductIon The exogenous chemicals and endogenous metabolites in the body produce reactive oxygen species (ROS), which are capable of oxidizing various biomolecules resulting in tissue damage and cell death. Free radicals have been implicated in the cause of several diseases such as liver cirrhosis, atherosclerosis, cancer and diabetes and play an important role in ageing. Oxidative stress can also contribute to the development of neuro-degenerative disorders, such as Alzheimer's and Parkinson's as well as other diseases. These free radicals attack unsaturated fatty acids of biomembranes, resulting in lipid peroxidation and desaturation of proteins and DNA, causing a series

Biochemical effect of Moringa peregrina Seeds on experimentally leukcytopenia in Rats

“…Our study suggested that 5-FUinduceddamage to the arterial endothelium may be due to generation of free radicals, resulting in lipid peroxidation (Asirvatham and Christina 2012). Phanolic compounds of Moringa peregrina seeds oil increases SOD and CAT activities in animals, hereby improving antioxidant potential (Hussein, 2010 andKoheil et al, 2011). In the present study, administration of benzene and/or 5flurouracil resulted in a significant decrease in blood GSH, SOD and CAT as well as plasma TC, TG, HDL-C and LDL-C with a significant increase in plasma TBARs compared to the normal control group.…”

“…The anti-Leukopenia effect of Moringa peregrina seeds oil was investigated using leucopenia induced rat model, when injected with benzene and/or 5-flurouracil by 2-weeks Aksoy, 1991 andSobrero et al, 1997. In this study, we observed and reported that Moringa peregrina seeds oil can normalize the levels of hematological parameters, which may be due to the presence of antioxidant phytochemicals (Hussein, 2010 andKoheil et al, 2011). Liver is considered to be the main organ of drug detoxifying organ, some lung marker enzyme levels were measured from plasma.…”

“…Many of the biological functions of flavonoids, phenolic, catechins, curcumin, resveratrol and genistein compounds have been attributed to their free radical scavenging, metal ion chelating and antioxidant activities (Ebenezer et al, 2011&Seef et al, 2011. Several medicinal plants have been implicated in the mechanisms of chemoprevention which refers to the use chemical substances of natural origin or synthetic to reverse, retard or delay the multistage carcinogenesis process (Ebenezer et al, 2011).One of such plants, Moringa peregrina ranks high among seeds in both antioxidant quality and quantity (Koheil et al, 2011) .Because of its substantial flavonoids content and a wealth of phenolic acids. Moringa peregrina tree belongs to the Moringaceae family, commonly known as a drumstick tree that is native to tropical widely naturalized and cultivated in many countries including Malaysia (Okuda et al, 2001).…”

“…A literature survey indicated that the presence of quercetin, flavonoids (Selvakumar& Natarajan, 2008), sterols (Yammuenart et al, 2008, tocopherols (γ and α), β-carotene and other antioxidants (Anwar et al, 2007) have been reported from the plant. The different extracts of the plant were also screened for In vitro anti-inflammatory and antioxidant activities (Koheil et al, 2011) as an extension of my interested research program in the extraction and therapeutic evaluation of rare medicinal plants (Hussein, 2008;Hussein, 2010;Hussein and Abdelgwade, 2010). We report herein, a facile route to explain antioxidant of Moringa peregrina seeds oil against benzene and/or 5-flurouracil induced leukopenia in female albino rats.…”

Regeneration and assessment of genetic fidelity of the endangered tree Moringa peregrina (Forsk.) Fiori using Inter Simple Sequence Repeat (ISSR)

“…In addition, Moringa is used as medicine for abdominal pain, headache, and skin protection as well as a laxative (Steinitz et al 2009). Recently, it has been shown that Moringa seeds contain potential anti-inflammatory and anti-oxidant factors (Koheil et al 2011).…”