Anti-inflammatory and Antiapoptotic Effects of Mesenchymal Stem Cells Transplantation in Rat Brain with Cerebral Ischemia

Coadministration of the Human Umbilical Cord Matrix-Derived Mesenchymal Cells and Aspirin Alters Postischemic Brain Injury in Rats

“…The mechanisms behind such reported neuroprotections are not clearly known but may include cytokines and trophic factors produced by mesenchymal cells. 22,23 In contrast, de Paula et al 24 showed significant spatial memory deficits after induced brain ischemia in rats. The alteration that was not significantly attenuated by the injection of human UC blood cells.…”

Magnetic Resonance Imaging of Ferumoxytol-Labeled Human Mesenchymal Stem Cells in the Mouse Brain

“…With such complications present, mesenchymal stem cells (MSCs) have become a promising therapeutic agent for AD stem cell therapy because of the multiple functional roles that they can mediate through their paracrine activities [9–11]. The multiple roles of MSCs, ranging from anti-apoptosis to anti-inflammation, make them ideal for the treatment of heterogeneous diseases such as AD where they can target more than one mechanism [12–15]. Using a transgenic AD mouse model, our group has observed the removal of amyloid plaques and acceleration of endogenous neurogenesis through treatment with MSCs [16–18].…”

Neuroprotective effect of human mesenchymal stem cells in a compartmentalized neuronal membrane system

“…Membrane system 27 2 8 a b s t r a c t 29 In this work, we describe the development of a compartmentalized membrane system using neonatal 30 rodent hippocampal cells and human mesenchymal stem cells (hMSCs) to investigate the neuroprotec- 31 tive effects of hMSCs. To elucidate this interaction an in vitro oxygen-glucose deprivation (OGD) model 32 was used that mimics central nervous system insults in vivo.…”