Coadministration of the Human Umbilical Cord Matrix-Derived Mesenchymal Cells and Aspirin Alters Postischemic Brain Injury in Rats

Abstract

The results of the present study suggest that ASA and hUCM cells can withstand degenerative changes induced by artificial stroke in the rat. Also the learning and memory disturbance in the ASA and cell-treated animals is less pronounced than ischemic animals. Coadministration of ASA and hUCM cells did not raise the outcome higher than administration of ASA and hUCM cells alone.

Aspirin Enhances Osteogenic Potential of Periodontal Ligament Stem Cells (PDLSCs) and Modulates the Expression Profile of Growth Factor–Associated Genes in PDLSCs

“…This observation is comparable to that of rat BMMSCs, where 1,000 μM ASA treatment decreased cell proliferation rate to only 82% 13 . ASA at concentrations ≤1,000 μM were also reported to modestly inhibit the proliferation of a variety of other cell types 9 , 10 , 14 …”

“…13 ASA at concentrations £1,000 mM were also reported to modestly inhibit the proliferation of a variety of other cell types. 9,10,14 Contrary to the above observation, the proliferation rate of the progenitor cells were higher in osteogenic media in the presence of 500 and 1,000 mM ASA (Fig. 3A).…”

“…ASA anti‐inflammatory action is achieved by the disruption of cyclic prostanoids biosynthesis, through the inhibition of the enzyme cyclooxygenase‐2 activity 8 . The effect of ASA on stem cells and its potential use have been reported in a number of studies 9–11 . Liu et al 9 reported that ASA treatment on stem cells from exfoliated deciduous teeth (SHED) at low dosages (≈55 and 277 μM) resulted in the activation of telomerase reverse transcription (TERT) activity, which improved SHED osteogenesis and immunomodulatory properties.…”

“…The authors suggested that low‐dose ASA therapy is a feasible and efficient pharmacologic approach to activating TERT activity in stem cells, which may improve stem cell functions, avoid replicative senescence, and achieve the therapeutic effects of stem cells. One study 10 reported that administration of ASA and human umbilical cord matrix–derived mesenchymal stem cells reduced the effect of post‐ischemic brain injury in the rat induced by artificial stroke. Liu et al 11 reported that BMMSC‐based calvarial bone defect repair in C57BL/6 mice was enhanced by site‐specific ASA treatment, and this was attributable to the suppression of tumor necrosis factor ( TNFα ) and interferon γ concentrations (and action) at the implantation site.…”

“…8 The effect of ASA on stem cells and its potential use have been reported in a number of studies. [9][10][11] Liu et al 9 reported that ASA treatment on stem cells from exfoliated deciduous teeth (SHED) at low dosages (55 and 277 mM) resulted in the activation of telomerase reverse transcription (TERT) activity, which improved SHED osteogenesis and immunomodulatory properties. The authors suggested that low-dose ASA therapy is a feasible and efficient pharmacologic approach to activating TERT activity in stem cells, which may improve stem cell functions, avoid replicative senescence, and achieve the therapeutic effects of stem cells.…”