Anti-Inflammatory Activity of Pandanus odoratissimus Extract

Londonkar, Ramesh L; Kamble, Abhaykumar; Reddy, Vishali

doi:10.3923/ijp.2010.311.314

Cited by 21 publications

(11 citation statements)

References 7 publications

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“…Dried plant powder weighed carefully and used for extract preparation through soxhlet apparatus at respective temperature. The extract obtained was filtered and concentrated in rotary evaporator [14,15]. The concentrated plant extracts (semi-solid mass) were lyophilized and than store the dried organic extracts in air tight brown bottles.…”

Section: Preparation Of Plant Extractsmentioning

confidence: 99%

Qualitative and Quantitative Determination of Secondary metabolites and Antioxidant Potential of Eruca sativa

Sadiq

Hayat²,

Mall³

2014

Nat Prod Chem Res 2014

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Objective: To Determine the phytochemical composition of E. sativa (stem, leaves, flowers and seeds), and evaluate their antioxidant activity. Method: Preliminary phytochemical screening for all parts of E. sativa (stem, leaves, flowers and seeds) was carried out according to standard methods. Total phenolic contents of all methanolic extracts of E. sativa, have been quantified spectrophotometrically. Hydrogen Peroxidase and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical assays have been used to analyze antioxidant characteristics of all extracts of E. sativa (leaves, stem, seed, flowers and seeds). Further separation and identification of number of phenolic compounds has been carried out by Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC). Results: Experimental evaluation indicated that E. sativa is a rich source of secondary phytoconstituents (Alkaloids, flavonoids, Diterpenes, Coumarins, polyphenols, tannins, cardiac glycosides etc). Quantification of total phenolic contents from all aerial parts revealed that they contain significant amount of phenolics particularly seeds and leaves (27.1 ± 0.2 mg, 23.07 ± 0.11GAE/g) respectively. Searation and identification of phenolics from E. sativa stem, leaves, flowers and seeds extracts through RP-HPLC showed presence of variety of important phenolics namely; Vanillin (RT=3.853), Ellagic acid (RT=4.04), Salicylic acid (RT=19.09), Resorcinol (RT=3.30), Catechol (RT=3.53), Quercetin (RT=18.91), Benzoic acid (RT=10.4), Tannic acid (RT=5.06), Kaempferol (RT=8.70) and Rutin (RT=9.2). Conclusion: Results revealed that E. sativa is a rich source of secondary phytoconstituents which impart significant antioxidant potential. This work also contributes significantly to support the claim about the use of this herb in folk medicines. Further investigation regarding isolation and purification of a number of phytoconstituents from leaves, stem, flowers and seeds of E. sativa may yield optimal combinations of therapeutic alternates.

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Section: Preparation Of Plant Extractsmentioning

confidence: 99%

Qualitative and Quantitative Determination of Secondary metabolites and Antioxidant Potential of Eruca sativa

Sadiq

Hayat²,

Mall³

2014

Nat Prod Chem Res 2014

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“…It is experimentally validated that P. odoratissimus possess antibacterial (Wei et al 2008;Kumar et al 2010;El-Shaibany 2014), anti-inflammatory (Londonkar et al 2010), antioxidant (Jong and Chau 1998;Londonkar and Kamble 2009;Sasikumar et al 2009;El-Shaibany 2014), antitumor (Panigrahi et al 2011), antidiabetic , antiepileptic (Adkar et al 2014), anti-hyperlipidemic (Zhang et al 2013), CNS depressant (Raju et al 2011), nocturnal enuresis (El-Shaibany 2014), hepatoprotective and hepatocurative (Ilanchezhian and Joseph 2010;Londonkar and Kamble 2011) activities. The principle constituent of P. odoratissimus oil, b-phenyl ethyl methyl ether, is responsible for the characteristic aroma of spadices.…”

Section: Introductionmentioning

confidence: 98%

Comparative study of antidiarrheal activity of methanol extracts from leaf and fruit of Pandanus odoratissimus Linn

Rahman

Islam

Barua

et al. 2014

Orient Pharm Exp Med

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Pandanus odoratissimus, a perennial, large shrub or small tree, has multifarious medicinal uses. The purpose of the present study was to evaluate the antidiarrheal effects of methanol extracts obtained from leaf and fruit of P. odoratissimus. The methanol extracts from the leaf and fruit of P. odoratissimus were evaluated for the antidiarrheal activity in rats. The effects of the extracts on defecation, intestinal transit and intestinal fluid accumulation (enteropooling) were assessed in castor oil-induced diarrhea. Oral administration of leaf and fruit extracts at 200 and 400 mg/kg exhibited significant (P<0.05-0.01) and dose-dependent antidiarrheal potential in castor oilinduced diarrhea. The diarrheal episode was inhibited by 34.30 % and 47.60 % by leaf extract, whereas 35.11 % and 47.15 % by fruit extract at the doses of 200 and 400 mg/kg respectively. The extracts were found to possess an antienteropooling in castor oil-induced experimental animals by reducing both weight and volume of intestinal content significantly and also decrease in intestinal transit comparable to that of standard drug, loperamide (5 mg/kg). These findings revealed that methanol extracts of leaf and fruit of P. odoratissimus possess significant antidiarrheal activities.

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“…Chemical component analysis of the root parts led to the isolation of two phenolic compounds, four lignan type compounds plus a new benzofuran derivative which showed strong antioxidative activities [12]. P. odoratissimus L. (whole plant) exhibit significant antitumor and antioxidant activities [13]; and its leaves possess potential CNS-depressant action [14] as well as anti-inflammatory activity [15]. Moreover, the leaves are reported to have natural antioxidant properties [16,17] and moderate activity against gram-positive bacteria [15].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect of <i>Pandanus odoratissimus</i> L Inflorescence Extracts in Acetaminophen-treated Guinea Pigs

El-Shaibany¹,

AL-Habori²,

Al-Massarani³

et al. 2016

Trop. J. Pharm Res

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Anti-Inflammatory Activity of Pandanus odoratissimus Extract

Cited by 21 publications

References 7 publications

Qualitative and Quantitative Determination of Secondary metabolites and Antioxidant Potential of Eruca sativa

Qualitative and Quantitative Determination of Secondary metabolites and Antioxidant Potential of Eruca sativa

Comparative study of antidiarrheal activity of methanol extracts from leaf and fruit of Pandanus odoratissimus Linn

Hepatoprotective Effect of <i>Pandanus odoratissimus</i> L Inflorescence Extracts in Acetaminophen-treated Guinea Pigs

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