Anti-inflammatory activity of ethanolic leaf extracts from<i>Adenanthera pavonina</i>(l) in Rats

Candasamy, Mayuren; Ilavarasan, R.

doi:10.4103/0975-1483.55744

Cited by 15 publications

(13 citation statements)

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“…[19][20][21] The study reveals that the extract has exhibited dose dependent activity and is at par to previous studies 10 due to presence of steroids, alkaloids and triterpenoids in the extract. 11,[13][14][15] Migration of WBC during the process of inflammation is a biological marker in inflammatory studies. On assessing the hematological parameters it was seen that at both the doses of extract there is decrease in leucocyte and PMN count depicting that the action is not dose dependent.…”

Section: Discussionmentioning

confidence: 99%

“…Administration of indomethacin and the plant extract was done by p.o. route 13,14 . A mark was made at the ankle up till which the paw was dipped and paw volume was measured at interval of 1 h, 2 h, 3 h and 5 h using a plethysmometer.…”

Section: Carrageenan Induced Paw Edema In Ratsmentioning

confidence: 99%

“…Drug treatment was started 1 h prior to cotton pellet implantation and the treatment was continued for the next 14 days. 11,[13][14][15] . On day 15, blood samples were collected through the retro-orbital route under light anaesthesia and subjected to differential leukocyte count.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Solanum nigrum Linn on Acute and Sub-Acute Models of Inflammation

Ankalikar¹,

Viswanathswamy²

2017

JYP

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Objective: The aim of the study was to see the effect of ethanolic extract of Solanum nigrum Linn on Acute and Sub-acute inflammation. Method: Wistar rats weighing 150-200gms were used, divided into four groups Group 1 was control group, two groups Group 2 and 3 treated with the plant extracts at 100 & 200 mg/kg b.w and Group 4 treated with indomethacin, 10 mg/kg b.w. Acute inflammation was induced by injecting 0.1 mL of 1% homogenized carrageenan suspension in normal saline to the right hind paw of the rats prior to which drug treatment was given and paw volume was measured using a digital plethysmometer. Sub-acute anti-inflammatory studies were carried out as described by winter and Porter and hematological parameters were estimated. The granuloma tissue formed during the proliferative process was isolated and wet and dry exudates formation was estimated in various treatment groups. The effect of extract and indomethacin on vital organs like liver, kidney, stomach was also studied by performing histological studies. Results: Study shows that the hydroalcoholic extract of whole plant of Solanum nigrum L. is effective only at higher dose effectively suppressing carrageenan induced inflammation suggesting the inhibition of release of prostaglandin, bradykinin, leukotrienes and polymorphonuclear cells. The histological studies further confirm the anti-inflammatory property of the extract while simultaneously maintaining normal cellular architecture of vital organs than as compared to indomethacin treated group. Conclusion: The ethanolic extract of whole plant of Solanum nigrum Linn shows promising anti-inflammatory activity on both acute and sub-acute stages of inflammation.Key words: Acute Inflammation, Sub-acute Inflammation, Anti-inflammatory activity, Solanum nigrum, Hematological parameters, Histological studies.Key Message: Inflammation is a typical reaction which gets triggered due to external influences. Solanum nigrum is a weed which is commonly found throughout the country and which has been claimed traditionally for its use as anti-diarroheal, analgesic and anti-hyperlipedemic. This study mainly involves in-vivo effect of the hydroalcoholic extract of the whole plant on acute inflammation induced using carrageenan and sub-acute inflammation induced using cotton pellet. The plant has elicited significant anti-inflammatory activity on acute as well as sub-acute stages of inflammation decreasing the paw volume and controlling the secretion of proinflammatory mediators. Evaluating the plant further for its effects on biochemical biomarkers and its chemical profiling is required and is in process This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.Aryaa and Viswanathswamy: Effect of S.nigrum on stages of inflammation

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Section: Discussionmentioning

confidence: 99%

Section: Carrageenan Induced Paw Edema In Ratsmentioning

confidence: 99%

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Effect of Solanum nigrum Linn on Acute and Sub-Acute Models of Inflammation

Ankalikar¹,

Viswanathswamy²

2017

JYP

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“…Thus, results generated from this study demonstrated the antiinflamatory and analgesic potential effects of the methanolic extract obtained from A. pavonina seeds (Olajide et al, 2004). Using the ethanolic extract from A. pavonina's leaves, Mayuren and Ilavarasan (2009) evaluated their antiinflammatory effects in Wistar rats at doses of 250 and 500 mg/kg in carrageenan-induced hind paw edema tests. Also, the chronic inflammation was measured using the cotton pellet-induced granuloma formation assay.…”

Section: Anti-inflammatory Activitymentioning

confidence: 73%

“…Other stigmasterol glucosides, including octacosanol and dulcitol, have also been reported in the leaves of this plant (Mayuren and Ilavarasan, 2009;Moniruzzaman et al, 2015). Zeid et al (2012) also isolated at the first time three triterpenoid compounds identified as 22-hydroxy hopan-3-one (A), 24-methylene cycloartenol (B) and betulinic acid (C) (Appendix A4).…”

Section: Phytochemical Analysis Of Leavesmentioning

confidence: 77%

Advances in the research of Adenanthera pavonina: From traditional use to intellectual property

GeronÃ§o¹,

Melo²,

Barros³

et al. 2020

J. Med. Plants Res.

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Adenanthera pavonina, an Asian native leguminous, is a well known highly used plant in traditional medicine. Such broad herbal medicine applications motivated several researchers to study its chemical composition, mainly of its leaves, seeds, and barks, besides the pharmacological effects aiming to demonstrate scientific evidence of its empirical uses. Most studies have been conducted with plant derivatives, and more recent studies have focused on isolated compounds. The phytochemical screening revealed various secondary metabolites with diverse biological effects, including flavonoids, alkaloids, saponins, tannins, steroids, triterpenoids, polyphenols, anthraquinones, coumarins, glycosides and polysaccharides. Experimental studies of this plant have shown numerous pharmacological activities such as antidiarrheal, anti-inflammatory, antinociceptive, antioxidant, antimicrobial, anticancer, and others. Advances in the studies of phytochemistry and biological activity on this plant species over the last years led to the increasing interest of researchers in the protection of inventions focusing on its cosmetic, pharmaceutical and food applicability. This review summarizes the tremendous therapeutic and technological potential of A. pavonina that should be explored, opening new perspectives for future researches and the development of new products.

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Adenanthera pavonina

Lim¹

2011

Edible Medicinal and Non-Medicinal Plants

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Anti-inflammatory activity of ethanolic leaf extracts fromAdenanthera pavonina(l) in Rats

Abstract: Preparation of ethanolic extract of Adenanthera pavonina The leaves were shade-dried and made into a coarse powder which was passed through a 40-mesh sieve to get a uniform particle size and then used for extraction.

Cited by 15 publications

References 10 publications

Effect of Solanum nigrum Linn on Acute and Sub-Acute Models of Inflammation

Effect of Solanum nigrum Linn on Acute and Sub-Acute Models of Inflammation

Advances in the research of Adenanthera pavonina: From traditional use to intellectual property

Adenanthera pavonina

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