Advances in the research of Adenanthera pavonina: From traditional use to intellectual property

Abstract

Adenanthera pavonina, an Asian native leguminous, is a well known highly used plant in traditional medicine. Such broad herbal medicine applications motivated several researchers to study its chemical composition, mainly of its leaves, seeds, and barks, besides the pharmacological effects aiming to demonstrate scientific evidence of its empirical uses. Most studies have been conducted with plant derivatives, and more recent studies have focused on isolated compounds. The phytochemical screening revealed various secondary metabolites with diverse biological effects, including flavonoids, alkaloids, saponins, tannins, steroids, triterpenoids, polyphenols, anthraquinones, coumarins, glycosides and polysaccharides. Experimental studies of this plant have shown numerous pharmacological activities such as antidiarrheal, anti-inflammatory, antinociceptive, antioxidant, antimicrobial, anticancer, and others. Advances in the studies of phytochemistry and biological activity on this plant species over the last years led to the increasing interest of researchers in the protection of inventions focusing on its cosmetic, pharmaceutical and food applicability. This review summarizes the tremendous therapeutic and technological potential of A. pavonina that should be explored, opening new perspectives for future researches and the development of new products.

Optimization and Characterization of Phenolic Extraction Conditions and Antioxidant Activity Evaluation of Adenanthera pavonina L. Bark

“…This tree is also known as the red bead tree worldwide. Traditionally, different parts of this plant have been used to treat an extensive range of conditions including hypertension, boils, diabetes, diarrhea, arthritis, cholera, asthma, stomach bleeding, fever, indigestion, epilepsy, vomiting, pulmonary infections, and cancer [1][2][3]. Besides these, bark and leaves are also used as a remedy for ulcers, gout, dysentery, hematemesis, and rheumatism [4].…”

“…Several studies have investigated the phytochemical and pharmacological possibilities of various parts of A. pavonina in the past [5][6][7][8]. Pharmacological investigations have shown that different parts of this plant have antinociceptive, anti-inflammatory, analgesic, anti-diarrheal, antimicrobial, antioxidant, anti-hyperglycemic, and hypolipidemic properties [2,7,9]. Phytochemical studies have demonstrated that different parts of this plant contain a wide array of chemical compounds including phenolics, flavonoids, alkaloids, steroids, saponins, triterpenoids, and glycosides [7,10].…”

Antihyperglycemic and neuroprotective activity of Adenanthera pavonina bark against streptozotocin induced diabetic rats

“…Adenanthera pavonina (AP) is an important medicinal plant widely distributed in Asia and America. Various parts of AP are traditionally used for the management of various health illnesses such as boils, inflammations, arthritis, rheumatism, blood disorders, cholera, epilepsy, convulsion, paralysis, spasm, indigestion, pulmonary infection, chronic rheumatism, gout, haematuria, haematemesis, ulcer and diarrhea [5]. And also bark of AP have been scientifically evaluated for its anti-inflammatory [6], anticancer [7], antibacterial [8], antifungal [9], anthelmintic [10], antioxidant [11] and antihyperlipidemic activities [12].…”